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MORGAN STANLEY
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 391,467 | 24,948 | 11,086,345,000 | 794,493,000 | $28,320.00 |
| 12/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 366,519 | 86,988 | 10,291,852,000 | 10,283,945,000 | $28,080.00 |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 279,531 | -136,605 | 7,907,000 | -1,318,000 | $28.29 |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 416,136 | 85,605 | 9,225,000 | -397,000 | $22.17 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 330,531 | 72,595 | 9,622,000 | 1,145,000 | $29.11 |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 257,936 | 81,643 | 8,477,000 | 341,000 | $32.86 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 176,293 | -108,475 | 8,136,000 | -7,557,000 | $46.15 |
| 06/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 284,768 | -79,626 | 15,693,000 | -3,124,000 | $55.11 |
| 03/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 364,394 | 142,214 | 18,817,000 | 9,190,000 | $51.64 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 222,180 | -221,528 | 9,627,000 | -5,905,000 | $43.33 |
| 09/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 443,708 | 393,452 | 15,532,000 | 12,845,000 | $35.01 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 50,256 | -72,128 | 2,687,000 | -1,655,000 | $53.47 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 122,384 | -31,285 | 4,342,000 | -2,996,000 | $35.48 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 153,669 | 130,680 | 7,338,000 | 6,594,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 22,989 | -56,567 | 744,000 | -3,223,000 | $32.36 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 79,556 | 21,107 | 3,967,000 | 25,000 | $49.86 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 58,449 | -20,237 | 3,942,000 | 314,000 | $67.44 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 78,686 | 28,737 | 3,628,000 | -225,000 | $46.11 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 49,949 | -39,251 | 3,853,000 | -3,661,000 | $77.14 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 89,200 | 20,827 | 7,514,000 | 1,922,000 | $84.24 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 68,373 | 13,534 | 5,592,000 | 2,457,000 | $81.79 |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 54,839 | -48,073 | 3,135,000 | -3,734,000 | $57.17 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 102,912 | 26,737 | 6,869,000 | 2,950,000 | $66.75 |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 76,175 | 11,840 | 3,919,000 | 3,915,244 | $51.45 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 64,335 | -19,537 | 3,756 | -3,495,244 | $0.06 |
| 12/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 83,872 | -14,211 | 3,499,000 | -1,682,000 | $41.72 |
| 09/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 98,083 | 98,083 | 5,181,000 | 5,181,000 | $52.82 |
| 06/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 106,904 | 106,904 | 4,479,000 | 4,479,000 | $41.90 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 119,530 | 119,530 | 4,853,000 | 4,853,000 | $40.60 |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 139,533 | 139,533 | 9,058,000 | 9,058,000 | $64.92 |
| 09/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 140,640 | 140,640 | 9,928,000 | 9,928,000 | $70.59 |
| 06/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 166,776 | 166,776 | 18,536,000 | 18,536,000 | $111.14 |
| 03/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 187,941 | 187,941 | 17,724,000 | 17,724,000 | $94.31 |
| 12/31/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 231,236 | 231,236 | 25,908,000 | 25,908,000 | $112.04 |
| 09/30/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 210,309 | 210,309 | 12,903,000 | 12,903,000 | $61.35 |
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