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Bank of New York Mellon Corp
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 209,946 | 3,232 | 5,945,669,000 | 1,197,449,000 | $28,319.99 |
| 03/31/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 206,714 | 1,047 | 4,748,220,000 | -1,026,908,000 | $22,970.00 |
| 12/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 205,667 | 205,667 | 5,775,128,000 | 5,775,128,000 | $28,079.99 |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -300,549 | 0 | -6,664,000 | |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 300,549 | -68,369 | 6,664,000 | -4,076,000 | $22.17 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 368,918 | -227 | 10,740,000 | -1,393,000 | $29.11 |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 369,145 | 89,698 | 12,133,000 | -763,000 | $32.87 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 279,447 | 1,603 | 12,896,000 | -2,416,000 | $46.15 |
| 06/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 277,844 | 41,486 | 15,312,000 | 5,071,000 | $55.11 |
| 03/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -236,358 | 0 | -10,241,000 | |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 236,358 | -4,818 | 10,241,000 | 1,800,000 | $43.33 |
| 09/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 241,176 | 4,770 | 8,441,000 | -4,201,000 | $35.00 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 236,406 | 10,395 | 12,642,000 | 4,624,000 | $53.48 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 226,011 | 8,601 | 8,018,000 | -2,363,000 | $35.48 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 217,410 | 19,306 | 10,381,000 | 3,962,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 198,104 | -8,040 | 6,419,000 | -3,864,000 | $32.40 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 206,144 | -5,187 | 10,283,000 | -3,968,000 | $49.88 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 211,331 | 1,160 | 14,251,000 | 4,560,000 | $67.43 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 210,171 | -5,121 | 9,691,000 | -6,911,000 | $46.11 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 215,292 | 2,559 | 16,602,000 | -1,316,000 | $77.11 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 212,733 | 6,169 | 17,918,000 | 1,026,000 | $84.23 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 206,564 | 32,535 | 16,892,000 | 6,943,000 | $81.78 |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 174,029 | -2,376 | 9,949,000 | -1,826,000 | $57.17 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 176,405 | 6,632 | 11,775,000 | 3,040,000 | $66.75 |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 169,773 | 43,058 | 8,735,000 | 1,335,000 | $51.45 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 126,715 | -1,291 | 7,400,000 | 2,057,000 | $58.40 |
| 12/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 128,006 | 21,182 | 5,343,000 | -298,000 | $41.74 |
| 09/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 106,824 | 106,824 | 5,641,000 | 5,641,000 | $52.81 |
| 06/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 108,966 | -1,079 | 4,564,000 | 97,000 | $41.88 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 110,045 | 8,141 | 4,467,000 | -2,149,000 | $40.59 |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 101,904 | -1,153 | 6,616,000 | -659,000 | $64.92 |
| 09/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 103,057 | 23,110 | 7,275,000 | -1,611,000 | $70.59 |
| 06/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 79,947 | 1,836 | 8,886,000 | 5,307,000 | $111.15 |
| 03/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 90,847 | 9,810 | 8,567,000 | -512,000 | $94.30 |
| 12/31/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 81,037 | 2,810 | 9,079,000 | 4,280,000 | $112.04 |
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