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PICTET ASSET MANAGEMENT SA
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | IONIS PHARMACEUTICALS INC | IONS | 3,095,670 | 1,982,628 | 127,015,340,000 | 87,235,219,000 | $41,030.00 |
| 03/31/2023 | IONIS PHARMACEUTICALS INC | IONS | 1,113,042 | 836,065 | 39,780,121,000 | 39,767,870,000 | $35,740.00 |
| 09/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 276,977 | 38,638 | 12,251,000 | 3,428,000 | $44.23 |
| 06/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 238,339 | 32,198 | 8,823,000 | 1,188,000 | $37.02 |
| 03/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 206,141 | 23,054 | 7,635,000 | 2,064,000 | $37.04 |
| 12/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 183,087 | 47,391 | 5,571,000 | 1,020,000 | $30.43 |
| 09/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 135,696 | 135,696 | 4,551,000 | 4,551,000 | $33.54 |
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