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DIMENSIONAL FUND ADVISORS LP
> MBRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2009 | METABASIS THERAPEUTICS INC | MBRX | 508,114 | -3,500 | 196,000 | -29,000 | $0.39 |
| 09/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 511,614 | -8,400 | 225,000 | -66,000 | $0.44 |
| 06/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 520,014 | -53,614 | 291,000 | -115,000 | $0.56 |
| 03/31/2009 | METABASIS THERAPEUTICS INC | MBRX | 573,628 | -53,071 | 406,000 | 205,000 | $0.71 |
| 12/31/2008 | METABASIS THERAPEUTICS INC | MBRX | 626,699 | -32,452 | 201,000 | -544,000 | $0.32 |
| 09/30/2008 | METABASIS THERAPEUTICS INC | MBRX | 659,151 | 659,151 | 745,000 | 745,000 | $1.13 |
| 06/30/2008 | METABASIS THERAPEUTICS INC | MBRX | 678,979 | 678,979 | 1,052,000 | 1,052,000 | $1.55 |
| 03/31/2008 | METABASIS THERAPEUTICS INC | MBRX | 670,085 | 670,085 | 1,380,000 | 1,380,000 | $2.06 |
| 12/31/2007 | METABASIS THERAPEUTICS INC | MBRX | 674,285 | -100 | 2,016,000 | 47,000 | $2.99 |
| 09/30/2007 | METABASIS THERAPEUTICS INC | MBRX | 674,385 | -3,400 | 1,969,000 | -2,775,000 | $2.92 |
| 06/30/2007 | METABASIS THERAPEUTICS INC | MBRX | 677,785 | 131,793 | 4,744,000 | 731,000 | $7.00 |
| 03/31/2007 | METABASIS THERAPEUTICS INC | MBRX | 545,992 | 215,360 | 4,013,000 | 1,527,000 | $7.35 |
| 12/29/2006 | METABASIS THERAPEUTICS INC | MBRX | 330,632 | 5,947 | 2,486,000 | 661,000 | $7.52 |
| 09/30/2006 | METABASIS THERAPEUTICS INC | MBRX | 324,685 | 30,148 | 1,825,000 | -422,000 | $5.62 |
| 06/30/2006 | METABASIS THERAPEUTICS INC | MBRX | 294,537 | 144,400 | 2,247,000 | 882,000 | $7.63 |
| 03/31/2006 | METABASIS THERAPEUTICS INC | MBRX | 150,137 | 125,759 | 1,365,000 | 1,170,000 | $9.09 |
| 12/30/2005 | METABASIS THERAPEUTICS INC | MBRX | 24,378 | 24,378 | 195,000 | 195,000 | $8.00 |
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