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TEACHERS ADVISORS, LLC
> MDCO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 03/31/2019 | MEDICINES CO /DE | MDCO | 262,126 | 4,101 | 7,326,000 | 2,387,000 | $27.95 |
| 12/31/2018 | MEDICINES CO /DE | MDCO | 258,025 | 392 | 4,939,000 | -2,767,000 | $19.14 |
| 09/30/2018 | MEDICINES CO /DE | MDCO | 257,633 | 3,164 | 7,706,000 | -1,633,000 | $29.91 |
| 06/30/2018 | MEDICINES CO /DE | MDCO | 254,469 | 4,191 | 9,339,000 | 1,095,000 | $36.70 |
| 03/31/2018 | MEDICINES CO /DE | MDCO | 250,278 | 4,052 | 8,244,000 | 1,512,000 | $32.94 |
| 12/31/2017 | MEDICINES CO /DE | MDCO | 246,226 | 121,383 | 6,732,000 | 2,108,000 | $27.34 |
| 09/30/2017 | MEDICINES CO /DE | MDCO | 124,843 | -190 | 4,624,000 | -129,000 | $37.04 |
| 06/30/2017 | MEDICINES CO /DE | MDCO | 125,033 | -267,175 | 4,753,000 | -14,426,000 | $38.01 |
| 03/31/2017 | MEDICINES CO /DE | MDCO | 392,208 | 3,834 | 19,179,000 | 5,998,000 | $48.90 |
| 12/31/2016 | MEDICINES CO /DE | MDCO | 388,374 | 27,042 | 13,181,000 | -456,000 | $33.94 |
| 09/30/2016 | MEDICINES CO /DE | MDCO | 361,332 | -52,175 | 13,637,000 | -2,060,000 | $37.74 |
| 06/30/2016 | MEDICINES CO /DE | MDCO | 306,060 | 84,600 | 10,293,000 | 3,257,000 | $33.63 |
| 03/31/2016 | MEDICINES CO /DE | MDCO | 221,460 | -135,784 | 7,036,000 | -6,303,000 | $31.77 |
| 12/31/2015 | MEDICINES CO /DE | MDCO | 357,244 | -56,263 | 13,339,000 | -2,358,000 | $37.34 |
| 09/30/2015 | MEDICINES CO /DE | MDCO | 413,507 | 413,507 | 15,697,000 | 15,697,000 | $37.96 |
| 06/30/2015 | MEDICINES CO /DE | MDCO | 413,777 | 413,777 | 11,838,000 | 11,838,000 | $28.61 |
| 03/31/2015 | MEDICINES CO /DE | MDCO | 409,225 | 409,225 | 11,466,000 | 11,466,000 | $28.02 |
| 12/31/2014 | MEDICINES CO /DE | MDCO | 511,043 | 511,043 | 14,141,000 | 14,141,000 | $27.67 |
| 09/30/2014 | MEDICINES CO /DE | MDCO | 495,543 | 495,543 | 11,061,000 | 11,061,000 | $22.32 |
| 06/30/2014 | MEDICINES CO /DE | MDCO | 495,543 | 495,543 | 14,400,000 | 14,400,000 | $29.06 |
| 03/31/2014 | MEDICINES CO /DE | MDCO | 486,993 | 486,993 | 13,840,000 | 13,840,000 | $28.42 |
| 12/31/2013 | MEDICINES CO /DE | MDCO | 464,857 | 464,857 | 17,953,000 | 17,953,000 | $38.62 |
| 09/30/2013 | MEDICINES CO /DE | MDCO | 461,907 | 10,282 | 15,483,000 | 1,591,000 | $33.52 |
| 06/30/2013 | MEDICINES CO /DE | MDCO | 451,625 | 4,787 | 13,892,000 | -1,041,326 | $30.76 |
| 03/31/2013 | MEDICINES CO /DE | MDCO | 446,838 | 143,750 | 14,933,326 | 7,668,326 | $33.42 |
| 12/31/2012 | MEDICINES CO /DE | MDCO | 303,088 | 63,247 | 7,265,000 | 1,075,000 | $23.97 |
| 09/30/2012 | MEDICINES CO /DE | MDCO | 239,841 | -237,868 | 6,190,000 | -4,769,000 | $25.81 |
| 06/30/2012 | MEDICINES CO /DE | MDCO | 477,709 | 71,151 | 10,959,000 | 2,799,000 | $22.94 |
| 03/31/2012 | MEDICINES CO /DE | MDCO | 406,558 | -16,674 | 8,160,000 | 1,862,000 | $20.07 |
| 12/31/2011 | MEDICINES CO /DE | MDCO | 389,362 | -33,870 | 7,258,000 | 960,000 | $18.64 |
| 09/30/2011 | MEDICINES CO /DE | MDCO | 423,232 | 158,586 | 6,298,000 | 1,929,000 | $14.88 |
| 06/30/2011 | MEDICINES CO /DE | MDCO | 264,646 | 71,280 | 4,369,000 | 1,219,000 | $16.51 |
| 03/31/2011 | MEDICINES CO /DE | MDCO | 193,366 | -34,090 | 3,150,000 | -64,000 | $16.29 |
| 12/31/2010 | MEDICINES CO /DE | MDCO | 227,456 | -109,736 | 3,214,000 | -1,574,000 | $14.13 |
| 09/30/2010 | MEDICINES CO /DE | MDCO | 337,192 | 11,280 | 4,788,000 | 2,308,000 | $14.20 |
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