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ADAGE CAPITAL PARTNERS GP, L.L.C.
> CRXX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2009 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 915,500 | -250,000 | 760,000 | -872,000 | $0.83 |
| 09/30/2009 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 1,165,500 | 0 | 1,632,000 | 699,000 | $1.40 |
| 06/30/2009 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 1,165,500 | 0 | 933,000 | 210,000 | $0.80 |
| 03/31/2009 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 1,165,500 | 0 | 723,000 | 0 | $0.62 |
| 12/31/2008 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 1,165,500 | 0 | 723,000 | -3,042,000 | $0.62 |
| 09/30/2008 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 1,165,500 | 1,165,500 | 3,765,000 | 3,765,000 | $3.23 |
| 06/30/2008 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 1,165,500 | 1,165,500 | 4,138,000 | 4,138,000 | $3.55 |
| 03/31/2008 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 1,165,500 | 1,165,500 | 4,009,000 | 4,009,000 | $3.44 |
| 12/31/2007 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 1,165,500 | 1,165,500 | 5,175,000 | 5,175,000 | $4.44 |
| 09/30/2007 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 665,500 | 665,500 | 4,113,000 | 4,113,000 | $6.18 |
| 06/30/2007 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 665,500 | 665,500 | 4,106,000 | 4,106,000 | $6.17 |
| 03/31/2007 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 565,500 | 565,500 | 3,953,000 | 3,953,000 | $6.99 |
| 12/31/2006 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 534,000 | 534,000 | 4,624,000 | 4,624,000 | $8.66 |
| 09/30/2006 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 465,500 | 465,500 | 2,900,000 | 2,900,000 | $6.23 |
| 06/30/2006 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 465,500 | 465,500 | 4,092,000 | 4,092,000 | $8.79 |
| 03/31/2006 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 465,500 | 465,500 | 5,539,000 | 5,539,000 | $11.90 |
| 12/31/2005 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 450,000 | 450,000 | 3,681,000 | 3,681,000 | $8.18 |
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