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Tyers Asset Management LLC
> MDCO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 09/30/2019 | MEDICINES CO /DE | MDCO | 14,336 | 672 | 717,000 | 219,000 | $50.01 |
| 06/30/2019 | MEDICINES CO /DE | MDCO | 13,664 | 392 | 498,000 | 127,000 | $36.45 |
| 03/31/2019 | MEDICINES CO /DE | MDCO | 13,272 | 0 | 371,000 | 117,000 | $27.95 |
| 12/31/2018 | MEDICINES CO /DE | MDCO | 13,272 | 2,996 | 254,000 | -53,000 | $19.14 |
| 09/30/2018 | MEDICINES CO /DE | MDCO | 10,276 | 2,072 | 307,000 | 6,000 | $29.88 |
| 06/30/2018 | MEDICINES CO /DE | MDCO | 8,204 | 364 | 301,000 | 43,000 | $36.69 |
| 03/31/2018 | MEDICINES CO /DE | MDCO | 7,840 | 0 | 258,000 | 44,000 | $32.91 |
| 12/31/2017 | MEDICINES CO /DE | MDCO | 7,840 | 1,120 | 214,000 | -35,000 | $27.30 |
| 09/30/2017 | MEDICINES CO /DE | MDCO | 6,720 | 924 | 249,000 | 29,000 | $37.05 |
| 06/30/2017 | MEDICINES CO /DE | MDCO | 5,796 | 5,796 | 220,000 | 220,000 | $37.96 |
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