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STATE STREET CORP
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | IONIS PHARMACEUTICALS INC | IONS | 3,974,453 | -244,276 | 163,071,807,000 | 3,730,413,000 | $41,030.00 |
| 12/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 4,218,729 | 457,774 | 159,341,394,000 | 159,175,047,000 | $37,770.00 |
| 09/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 3,760,955 | -441,919 | 166,347,000 | 10,757,000 | $44.23 |
| 06/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 4,202,874 | 172,228 | 155,590,000 | 6,295,000 | $37.02 |
| 03/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 4,030,646 | 124,271 | 149,295,000 | 30,424,000 | $37.04 |
| 12/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 3,906,375 | 385,061 | 118,871,000 | 766,000 | $30.43 |
| 09/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 3,521,314 | 290,363 | 118,105,000 | -10,778,000 | $33.54 |
| 06/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 3,230,951 | -178,620 | 128,883,000 | -24,411,000 | $39.89 |
| 03/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 3,409,571 | -503,757 | 153,294,000 | -67,966,000 | $44.96 |
| 12/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 3,913,328 | 358,434 | 221,260,000 | 52,580,000 | $56.54 |
| 09/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 3,554,894 | -35,529 | 168,680,000 | -43,011,000 | $47.45 |
| 06/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 3,590,423 | -302,471 | 211,691,000 | 27,635,000 | $58.96 |
| 03/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 3,892,894 | 45,509 | 184,056,000 | -48,365,000 | $47.28 |
| 12/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 3,847,385 | 196,602 | 232,421,000 | 13,703,000 | $60.41 |
| 09/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 3,650,783 | 65,104 | 218,718,000 | -11,734,000 | $59.91 |
| 06/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 3,585,679 | 1,032,591 | 230,452,000 | 23,218,000 | $64.27 |
| 03/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 2,553,088 | 17,919 | 207,234,000 | 70,183,000 | $81.17 |
| 12/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 2,535,169 | -479,547 | 137,051,000 | -18,450,000 | $54.06 |
| 09/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 3,014,716 | -44,302 | 155,501,000 | 28,031,000 | $51.58 |
| 06/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 3,059,018 | 306,476 | 127,470,000 | -10,984,000 | $41.67 |
| 12/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 2,752,542 | -189,279 | 138,454,000 | -10,699,000 | $50.30 |
| 09/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 2,941,821 | -22,169 | 149,153,000 | -1,626,000 | $50.70 |
| 06/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 2,963,990 | -376,481 | 150,779,000 | 16,494,000 | $50.87 |
| 03/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 3,340,471 | 567,792 | 134,285,000 | 1,673,000 | $40.20 |
| 12/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 2,772,679 | -811,925 | 132,612,000 | 1,273,000 | $47.83 |
| 09/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 3,584,604 | -662,307 | 131,339,000 | 32,424,000 | $36.64 |
| 06/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 4,246,911 | 1,209,523 | 98,915,000 | -24,095,000 | $23.29 |
| 03/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 3,037,388 | 3,037,388 | 123,010,000 | 123,010,000 | $40.50 |
| 12/31/2015 | IONIS PHARMACEUTICALS INC | IONS | 2,624,873 | 2,624,873 | 162,557,000 | 162,557,000 | $61.93 |
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