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STATE STREET CORP
> OPK
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | OPKO HEALTH, INC. | OPK | 9,144,996 | -1,300,322 | 19,844,641,000 | 6,787,993,000 | $2,170.00 |
| 12/31/2022 | OPKO HEALTH, INC. | OPK | 10,445,318 | 71,045 | 13,056,648,000 | 13,037,041,000 | $1,250.00 |
| 09/30/2022 | OPKO HEALTH, INC. | OPK | 10,374,273 | 507,764 | 19,607,000 | -5,355,000 | $1.89 |
| 06/30/2022 | OPKO HEALTH, INC. | OPK | 9,866,509 | -17,822,322 | 24,962,000 | -70,288,000 | $2.53 |
| 03/31/2022 | OPKO HEALTH, INC. | OPK | 27,688,831 | 10,014,088 | 95,250,000 | 10,234,000 | $3.44 |
| 12/31/2021 | OPKO HEALTH, INC. | OPK | 17,674,743 | -5,699,872 | 85,016,000 | -301,000 | $4.81 |
| 09/30/2021 | OPKO HEALTH, INC. | OPK | 23,374,615 | 2,577,407 | 85,317,000 | 1,088,000 | $3.65 |
| 06/30/2021 | OPKO HEALTH, INC. | OPK | 20,797,208 | 1,488,452 | 84,229,000 | 1,394,000 | $4.05 |
| 03/31/2021 | OPKO HEALTH, INC. | OPK | 19,308,756 | -3,558,594 | 82,835,000 | -7,491,000 | $4.29 |
| 12/31/2020 | OPKO HEALTH, INC. | OPK | 22,867,350 | -2,232,463 | 90,326,000 | -2,292,000 | $3.95 |
| 09/30/2020 | OPKO HEALTH, INC. | OPK | 25,099,813 | -5,358,538 | 92,618,000 | -11,245,000 | $3.69 |
| 06/30/2020 | OPKO HEALTH, INC. | OPK | 30,458,351 | 12,017,920 | 103,863,000 | 79,153,000 | $3.41 |
| 03/31/2020 | OPKO HEALTH, INC. | OPK | 18,440,431 | 542,095 | 24,710,000 | -1,601,000 | $1.34 |
| 12/31/2019 | OPKO HEALTH, INC. | OPK | 17,898,336 | 3,853,461 | 26,311,000 | -3,043,000 | $1.47 |
| 09/30/2019 | OPKO HEALTH, INC. | OPK | 14,044,875 | -4,363,277 | 29,354,000 | -15,562,000 | $2.09 |
| 06/30/2019 | OPKO HEALTH, INC. | OPK | 18,408,152 | -1,719,442 | 44,916,000 | -7,617,000 | $2.44 |
| 03/31/2019 | OPKO HEALTH, INC. | OPK | 20,127,594 | 4,485,484 | 52,533,000 | 5,450,000 | $2.61 |
| 12/31/2018 | OPKO HEALTH, INC. | OPK | 15,642,110 | -6,684,649 | 47,083,000 | -30,169,000 | $3.01 |
| 09/30/2018 | OPKO HEALTH, INC. | OPK | 22,326,759 | 7,265,701 | 77,252,000 | 6,468,000 | $3.46 |
| 06/30/2018 | OPKO HEALTH, INC. | OPK | 15,061,058 | 977,252 | 70,784,000 | 1,772,000 | $4.70 |
| 12/31/2017 | OPKO HEALTH, INC. | OPK | 14,083,806 | 1,462,485 | 69,012,000 | -17,575,000 | $4.90 |
| 09/30/2017 | OPKO HEALTH, INC. | OPK | 12,621,321 | 1,272,558 | 86,587,000 | 11,916,000 | $6.86 |
| 06/30/2017 | OPKO HEALTH, INC. | OPK | 11,348,763 | 422,203 | 74,671,000 | -12,741,000 | $6.58 |
| 03/31/2017 | OPKO HEALTH, INC. | OPK | 10,926,560 | 3,138,685 | 87,412,000 | 14,985,000 | $8.00 |
| 12/31/2016 | OPKO HEALTH, INC. | OPK | 7,787,875 | 226,132 | 72,427,000 | -7,652,000 | $9.30 |
| 09/30/2016 | OPKO HEALTH, INC. | OPK | 7,561,743 | 107,019 | 80,079,000 | 10,452,000 | $10.59 |
| 06/30/2016 | OPKO HEALTH, INC. | OPK | 7,454,724 | 773,867 | 69,627,000 | 210,000 | $9.34 |
| 03/31/2016 | OPKO HEALTH, INC. | OPK | 6,680,857 | 548,816 | 69,417,000 | 17,847,000 | $10.39 |
| 12/31/2015 | OPKO HEALTH, INC. | OPK | 6,717,794 | 585,753 | 67,510,000 | 15,940,000 | $10.05 |
| 09/30/2015 | OPKO HEALTH, INC. | OPK | 6,132,041 | 2,168,136 | 51,570,000 | -12,168,000 | $8.41 |
| 06/30/2015 | OPKO HEALTH, INC. | OPK | 3,963,905 | -853,721 | 63,738,000 | -4,529,000 | $16.08 |
| 03/31/2015 | OPKO HEALTH, INC. | OPK | 4,817,626 | -518,410 | 68,267,000 | 14,959,000 | $14.17 |
| 12/31/2014 | OPKO HEALTH, INC. | OPK | 5,336,036 | 255,832 | 53,308,000 | 10,080,000 | $9.99 |
| 09/30/2014 | OPKO HEALTH, INC. | OPK | 5,080,204 | 228,377 | 43,228,000 | 342,000 | $8.51 |
| 06/30/2014 | OPKO HEALTH, INC. | OPK | 4,851,827 | -276,351 | 42,886,000 | -4,911,000 | $8.84 |
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