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TWIN FOCUS CAPITAL PARTNERS, LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -1,122 | 0 | -353,509,000 | |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,122 | 0 | 353,509,000 | 353,184,000 | $315,070.41 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,122 | -20 | 325,000 | 3,000 | $289.66 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,142 | -22 | 322,000 | 18,000 | $281.96 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,164 | -34 | 304,000 | 41,000 | $261.17 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,198 | 93 | 263,000 | 63,000 | $219.53 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,105 | 7 | 200,000 | -21,000 | $181.00 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,098 | 26 | 221,000 | -9,000 | $201.28 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,072 | 52 | 230,000 | -11,000 | $214.55 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,020 | 40 | 241,000 | -26,000 | $236.27 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 980 | 27 | 267,000 | -10,000 | $272.45 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 953 | -1 | 277,000 | 50,000 | $290.66 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 954 | 18 | 227,000 | 22,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 936 | 936 | 205,000 | 205,000 | $219.02 |
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