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VANGUARD GROUP INC
> MBRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2009 | METABASIS THERAPEUTICS INC | MBRX | 395,811 | 47,700 | 152,000 | -1,000 | $0.38 |
| 09/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 348,111 | 0 | 153,000 | -42,000 | $0.44 |
| 06/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 348,111 | 0 | 195,000 | -52,000 | $0.56 |
| 03/31/2009 | METABASIS THERAPEUTICS INC | MBRX | 348,111 | 0 | 247,000 | 136,000 | $0.71 |
| 12/31/2008 | METABASIS THERAPEUTICS INC | MBRX | 348,111 | 0 | 111,000 | -282,000 | $0.32 |
| 09/30/2008 | METABASIS THERAPEUTICS INC | MBRX | 348,111 | 347,571 | 393,000 | 44,889 | $1.13 |
| 06/30/2008 | METABASIS THERAPEUTICS INC | MBRX | 540 | 303 | 348,111 | 233,050 | $644.65 |
| 03/31/2008 | METABASIS THERAPEUTICS INC | MBRX | 237 | 237 | 115,061 | 115,061 | $485.49 |
| 12/31/2007 | METABASIS THERAPEUTICS INC | MBRX | 353 | 353 | 115,061 | 115,061 | $325.95 |
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