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ORBIMED ADVISORS LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 165,400 | -12,200 | 58,205,914,000 | 2,249,482,000 | $351,910.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 177,600 | -93,900 | 55,956,432,000 | -22,447,338,000 | $315,070.00 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 271,500 | -101,700 | 78,403,770,000 | 78,295,714,000 | $288,780.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 373,200 | -14,000 | 108,056,000 | -1,053,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 387,200 | -13,000 | 109,109,000 | 4,669,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 400,200 | -257,900 | 104,440,000 | -40,079,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 658,100 | -407,300 | 144,519,000 | -70,298,000 | $219.60 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,065,400 | -70,500 | 214,817,000 | -29,277,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,135,900 | 301,800 | 244,094,000 | 46,963,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 834,100 | 168,000 | 197,131,000 | 15,872,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 666,100 | 0 | 181,259,000 | -12,116,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 666,100 | -71,300 | 193,375,000 | 17,911,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 737,400 | -45,700 | 175,464,000 | 4,004,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 783,100 | -63,300 | 171,460,000 | 28,063,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 846,400 | -126,900 | 143,397,000 | -35,087,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 973,300 | 18,000 | 178,484,000 | 2,757,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 955,300 | -177,900 | 175,727,000 | -12,056,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,133,200 | -467,300 | 187,783,000 | -120,697,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,600,500 | -192,100 | 308,480,000 | 3,810,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,792,600 | -62,000 | 304,670,000 | 2,407,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,854,600 | 113,300 | 302,263,000 | 41,312,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,741,300 | -333,002 | 260,951,000 | -54,426,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,074,302 | 47,800 | 315,377,000 | 54,222,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,026,502 | -142,698 | 261,155,000 | 23,953,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,169,200 | 9,800 | 237,202,000 | 78,119,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,159,400 | 547,400 | 159,083,000 | 18,500,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,612,000 | -577,300 | 140,583,000 | -47,741,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,189,300 | 2,189,300 | 188,324,000 | 188,324,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,869,400 | 1,196,400 | 148,599,000 | 63,915,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 673,000 | 586,000 | 84,684,000 | 81,039,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 115,000 | 28,000 | 11,976,000 | 8,331,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -87,000 | 0 | -3,645,000 | |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 135,000 | 48,000 | 15,926,000 | 12,281,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,731,200 | 1,644,200 | 205,667,000 | 202,022,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,350,000 | 1,263,000 | 151,619,000 | 147,974,000 | $112.31 |
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