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PINNACLE ASSOCIATES LTD
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 494,750 | -6,140 | 18,686,707,000 | 18,664,553,000 | $37,770.00 |
| 09/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 500,890 | -14,969 | 22,154,000 | 3,057,000 | $44.23 |
| 06/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 515,859 | -6,109 | 19,097,000 | -237,000 | $37.02 |
| 03/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 521,968 | -19,076 | 19,334,000 | 2,870,000 | $37.04 |
| 12/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 541,044 | -2,182 | 16,464,000 | -1,756,000 | $30.43 |
| 09/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 543,226 | 1,884 | 18,220,000 | -3,374,000 | $33.54 |
| 06/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 541,342 | 28,218 | 21,594,000 | -1,476,000 | $39.89 |
| 03/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 513,124 | -69,745 | 23,070,000 | -4,587,000 | $44.96 |
| 09/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 582,869 | -18,828 | 27,657,000 | -7,819,000 | $47.45 |
| 06/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 601,697 | -20,212 | 35,476,000 | 6,072,000 | $58.96 |
| 03/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 621,909 | -80,650 | 29,404,000 | -13,038,000 | $47.28 |
| 12/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 702,559 | -65,401 | 42,442,000 | -3,566,000 | $60.41 |
| 09/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 767,960 | -32,308 | 46,008,000 | -5,425,000 | $59.91 |
| 06/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 800,268 | -77,763 | 51,433,000 | -19,837,000 | $64.27 |
| 03/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 878,031 | -30,915 | 71,270,000 | 22,132,000 | $81.17 |
| 12/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 908,946 | -61,119 | 49,138,000 | -898,000 | $54.06 |
| 09/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 970,065 | -123,033 | 50,036,000 | 4,487,000 | $51.58 |
| 06/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 1,093,098 | -196,123 | 45,549,000 | -19,299,000 | $41.67 |
| 12/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 1,289,221 | -109,244 | 64,848,000 | -6,054,000 | $50.30 |
| 09/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 1,398,465 | -48,099 | 70,902,000 | -2,685,000 | $50.70 |
| 06/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 1,446,564 | -68,146 | 73,587,000 | 12,696,000 | $50.87 |
| 03/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 1,514,710 | -57,335 | 60,891,000 | -14,300,000 | $40.20 |
| 12/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 1,572,045 | -83,972 | 75,191,000 | 14,515,000 | $47.83 |
| 09/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 1,656,017 | -24,395 | 60,676,000 | 21,539,000 | $36.64 |
| 06/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 1,680,412 | 1,680,412 | 39,137,000 | 39,137,000 | $23.29 |
| 03/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 1,697,378 | 1,697,378 | 68,744,000 | 68,744,000 | $40.50 |
| 12/31/2015 | IONIS PHARMACEUTICALS INC | IONS | 1,690,263 | 1,690,263 | 104,678,000 | 104,678,000 | $61.93 |
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