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Regis Management CO LLC
> DRRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2022 | DURECT CORP | DRRX | 13,425 | -120,825 | 46,000 | -32,000 | $3.43 |
| 09/30/2022 | DURECT CORP | DRRX | 134,250 | 0 | 78,000 | 14,000 | $0.58 |
| 06/30/2022 | DURECT CORP | DRRX | 134,250 | 0 | 64,000 | -26,000 | $0.48 |
| 03/31/2022 | DURECT CORP | DRRX | 134,250 | 0 | 90,000 | -42,000 | $0.67 |
| 12/31/2021 | DURECT CORP | DRRX | 134,250 | 0 | 132,000 | -87,000 | $0.98 |
| 06/30/2021 | DURECT CORP | DRRX | 134,250 | 0 | 219,000 | -47,000 | $1.63 |
| 03/31/2021 | DURECT CORP | DRRX | 134,250 | 0 | 266,000 | -12,000 | $1.98 |
| 12/31/2020 | DURECT CORP | DRRX | 134,250 | 0 | 278,000 | 48,000 | $2.07 |
| 09/30/2020 | DURECT CORP | DRRX | 134,250 | 0 | 230,000 | -2,885,000 | $1.71 |
| 06/30/2020 | DURECT CORP | DRRX | 134,250 | 0 | 3,115,000 | 2,907,000 | $23.20 |
| 03/31/2020 | DURECT CORP | DRRX | 134,250 | 0 | 208,000 | -302,000 | $1.55 |
| 12/31/2019 | DURECT CORP | DRRX | 134,250 | 0 | 510,000 | 263,000 | $3.80 |
| 09/30/2019 | DURECT CORP | DRRX | 134,250 | 0 | 247,000 | 159,000 | $1.84 |
| 06/30/2019 | DURECT CORP | DRRX | 134,250 | 0 | 88,000 | 4,000 | $0.66 |
| 03/31/2019 | DURECT CORP | DRRX | 134,250 | 0 | 84,000 | 19,000 | $0.63 |
| 12/31/2018 | DURECT CORP | DRRX | 134,250 | 0 | 65,000 | -83,000 | $0.48 |
| 09/30/2018 | DURECT CORP | DRRX | 134,250 | 0 | 148,000 | -61,000 | $1.10 |
| 06/30/2018 | DURECT CORP | DRRX | 134,250 | 0 | 209,000 | -78,000 | $1.56 |
| 03/31/2018 | DURECT CORP | DRRX | 134,250 | 0 | 287,000 | 163,000 | $2.14 |
| 12/31/2017 | DURECT CORP | DRRX | 134,250 | 0 | 124,000 | -114,000 | $0.92 |
| 09/30/2017 | DURECT CORP | DRRX | 134,250 | 0 | 238,000 | 29,000 | $1.77 |
| 06/30/2017 | DURECT CORP | DRRX | 134,250 | 0 | 209,000 | 68,000 | $1.56 |
| 03/31/2017 | DURECT CORP | DRRX | 134,250 | 0 | 141,000 | -39,000 | $1.05 |
| 12/31/2016 | DURECT CORP | DRRX | 134,250 | 0 | 180,000 | -7,000 | $1.34 |
| 09/30/2016 | DURECT CORP | DRRX | 134,250 | 0 | 187,000 | 23,000 | $1.39 |
| 06/30/2016 | DURECT CORP | DRRX | 134,250 | 38,000 | 164,000 | 35,000 | $1.22 |
| 03/31/2016 | DURECT CORP | DRRX | 134,250 | 38,000 | 181,000 | 52,000 | $1.35 |
| 12/31/2015 | DURECT CORP | DRRX | 116,250 | 20,000 | 257,000 | 128,000 | $2.21 |
| 09/30/2015 | DURECT CORP | DRRX | 116,250 | 0 | 227,000 | -51,000 | $1.95 |
| 06/30/2015 | DURECT CORP | DRRX | 116,250 | 20,000 | 278,000 | 149,000 | $2.39 |
| 03/31/2015 | DURECT CORP | DRRX | 96,250 | 0 | 128,000 | -1,000 | $1.33 |
| 12/31/2014 | DURECT CORP | DRRX | 96,250 | 0 | 76,000 | -99,000 | $0.79 |
| 09/30/2014 | DURECT CORP | DRRX | 96,250 | 0 | 141,000 | -34,000 | $1.46 |
| 06/30/2014 | DURECT CORP | DRRX | 96,250 | 0 | 175,000 | 46,000 | $1.82 |
| 03/31/2014 | DURECT CORP | DRRX | 96,250 | 0 | 128,000 | -39,000 | $1.33 |
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