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CHARLES SCHWAB INVESTMENT MANAGEMENT INC
> DRRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2022 | DURECT CORP | DRRX | 113,441 | -480,734 | 55,000 | -344,000 | $0.48 |
| 03/31/2022 | DURECT CORP | DRRX | 594,175 | 0 | 399,000 | -187,000 | $0.67 |
| 12/31/2021 | DURECT CORP | DRRX | 594,175 | 20,184 | 586,000 | -350,000 | $0.99 |
| 06/30/2021 | DURECT CORP | DRRX | 573,991 | 26,288 | 936,000 | -149,000 | $1.63 |
| 03/31/2021 | DURECT CORP | DRRX | 547,703 | 56,265 | 1,085,000 | 67,000 | $1.98 |
| 12/31/2020 | DURECT CORP | DRRX | 491,438 | 13,221 | 1,018,000 | 200,000 | $2.07 |
| 09/30/2020 | DURECT CORP | DRRX | 478,217 | -8,953 | 818,000 | -313,000 | $1.71 |
| 06/30/2020 | DURECT CORP | DRRX | 487,170 | 402,683 | 1,131,000 | 1,000,000 | $2.32 |
| 03/31/2020 | DURECT CORP | DRRX | 84,487 | 0 | 131,000 | -191,000 | $1.55 |
| 12/31/2019 | DURECT CORP | DRRX | 84,487 | 42,902 | 322,000 | 245,000 | $3.81 |
| 09/30/2019 | DURECT CORP | DRRX | 41,585 | 0 | 77,000 | 49,000 | $1.85 |
| 06/30/2019 | DURECT CORP | DRRX | 41,585 | -301,576 | 28,000 | -187,000 | $0.67 |
| 03/31/2019 | DURECT CORP | DRRX | 343,161 | 0 | 215,000 | 49,000 | $0.63 |
| 12/31/2018 | DURECT CORP | DRRX | 343,161 | -133,403 | 166,000 | -359,000 | $0.48 |
| 09/30/2018 | DURECT CORP | DRRX | 476,564 | 0 | 525,000 | -219,000 | $1.10 |
| 06/30/2018 | DURECT CORP | DRRX | 476,564 | 213,088 | 744,000 | 180,000 | $1.56 |
| 03/31/2018 | DURECT CORP | DRRX | 263,476 | 0 | 564,000 | 321,000 | $2.14 |
| 12/31/2017 | DURECT CORP | DRRX | 263,476 | 0 | 243,000 | -224,000 | $0.92 |
| 09/30/2017 | DURECT CORP | DRRX | 263,476 | 100,200 | 467,000 | 212,000 | $1.77 |
| 06/30/2017 | DURECT CORP | DRRX | 163,276 | 0 | 255,000 | 83,000 | $1.56 |
| 03/31/2017 | DURECT CORP | DRRX | 163,276 | -14,500 | 172,000 | -67,000 | $1.05 |
| 12/31/2016 | DURECT CORP | DRRX | 177,776 | 0 | 239,000 | -9,000 | $1.34 |
| 09/30/2016 | DURECT CORP | DRRX | 177,776 | 0 | 248,000 | 31,000 | $1.40 |
| 06/30/2016 | DURECT CORP | DRRX | 177,776 | 177,776 | 217,000 | 217,000 | $1.22 |
| 03/31/2016 | DURECT CORP | DRRX | 177,776 | 0 | 240,000 | -153,000 | $1.35 |
| 12/31/2015 | DURECT CORP | DRRX | 177,776 | 0 | 393,000 | 46,000 | $2.21 |
| 09/30/2015 | DURECT CORP | DRRX | 177,776 | 163,276 | 347,000 | 332,000 | $1.95 |
| 06/30/2015 | DURECT CORP | DRRX | 177,776 | 163,276 | 425,000 | 397,000 | $2.39 |
| 03/31/2015 | DURECT CORP | DRRX | 14,500 | 0 | 28,000 | 6,000 | $1.93 |
| 12/31/2014 | DURECT CORP | DRRX | 14,500 | 0 | 12,000 | -10,000 | $0.83 |
| 09/30/2014 | DURECT CORP | DRRX | 14,500 | 0 | 22,000 | 2,000 | $1.52 |
| 06/30/2014 | DURECT CORP | DRRX | 14,500 | 0 | 27,000 | 7,000 | $1.86 |
| 03/31/2014 | DURECT CORP | DRRX | 14,500 | 0 | 20,000 | -1,000 | $1.38 |
| 12/31/2013 | DURECT CORP | DRRX | 14,500 | 0 | 26,000 | 5,000 | $1.79 |
| 09/30/2013 | DURECT CORP | DRRX | 14,500 | 0 | 21,000 | 6,000 | $1.45 |
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