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GOLDMAN SACHS GROUP INC
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 03/31/2023 | IONIS PHARMACEUTICALS INC | IONS | 422,098 | -868,467 | 15,085,783,000 | 15,028,702,000 | $35,740.00 |
| 09/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 1,290,565 | 248,741 | 57,081,000 | 18,512,000 | $44.23 |
| 06/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 1,041,824 | 452,526 | 38,569,000 | 20,636,000 | $37.02 |
| 12/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 589,298 | -12,538 | 17,933,000 | -2,253,000 | $30.43 |
| 09/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 601,836 | -77,593 | 20,186,000 | -6,916,000 | $33.54 |
| 06/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 679,429 | -364,625 | 27,102,000 | -31,928,000 | $39.89 |
| 12/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 1,044,054 | 453,994 | 59,030,000 | 31,032,000 | $56.54 |
| 09/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 590,060 | -173,718 | 27,998,000 | -17,034,000 | $47.45 |
| 06/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 763,778 | 44,028 | 45,032,000 | 11,002,000 | $58.96 |
| 03/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 719,750 | 184,724 | 34,030,000 | 1,709,000 | $47.28 |
| 12/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 535,026 | -35,203 | 32,321,000 | -1,841,000 | $60.41 |
| 09/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 570,229 | -918,846 | 34,162,000 | -61,541,000 | $59.91 |
| 06/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 1,489,075 | 997,199 | 95,703,000 | 55,777,000 | $64.27 |
| 03/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 491,876 | -693,876 | 39,926,000 | -24,176,000 | $81.17 |
| 12/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 1,185,752 | -409,723 | 64,102,000 | -18,193,000 | $54.06 |
| 09/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 1,595,475 | -69,548 | 82,295,000 | 12,913,000 | $51.58 |
| 06/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 1,665,023 | -263,875 | 69,382,000 | -27,642,000 | $41.67 |
| 12/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 1,928,898 | 242,041 | 97,024,000 | 11,500,000 | $50.30 |
| 09/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 1,686,857 | 221,721 | 85,524,000 | 10,993,000 | $50.70 |
| 06/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 1,465,136 | 728,147 | 74,531,000 | 44,904,000 | $50.87 |
| 03/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 736,989 | 44,372 | 29,627,000 | -3,501,000 | $40.20 |
| 12/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 692,617 | 637,369 | 33,128,000 | 31,104,000 | $47.83 |
| 09/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 55,248 | 55,248 | 2,024,000 | 2,024,000 | $36.63 |
| 06/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 64,702 | -23,117 | 1,507,000 | -2,050,000 | $23.29 |
| 03/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 87,819 | -458,048 | 3,557,000 | -30,249,000 | $40.50 |
| 12/31/2015 | IONIS PHARMACEUTICALS INC | IONS | 545,867 | 545,867 | 33,806,000 | 33,806,000 | $61.93 |
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