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TWO SIGMA INVESTMENTS, LP
> OMER
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | OMEROS CORP | OMER | 59,800 | 0 | 325,312,000 | 47,242,000 | $5,440.00 |
| 03/31/2023 | OMEROS CORP | OMER | 59,800 | -139,437 | 278,070,000 | -172,206,000 | $4,650.00 |
| 12/31/2022 | OMEROS CORP | OMER | 199,237 | -488,667 | 450,276,000 | 448,384,000 | $2,260.00 |
| 06/30/2022 | OMEROS CORP | OMER | 687,904 | 461,117 | 1,892,000 | 529,000 | $2.75 |
| 03/31/2022 | OMEROS CORP | OMER | 226,787 | -321,531 | 1,363,000 | -2,163,000 | $6.01 |
| 12/31/2021 | OMEROS CORP | OMER | 548,318 | 326,519 | 3,526,000 | 467,000 | $6.43 |
| 09/30/2021 | OMEROS CORP | OMER | 221,799 | -173,520 | 3,059,000 | -2,808,000 | $13.79 |
| 06/30/2021 | OMEROS CORP | OMER | 395,319 | 110,918 | 5,867,000 | 805,000 | $14.84 |
| 03/31/2021 | OMEROS CORP | OMER | 284,401 | 284,401 | 5,062,000 | 5,062,000 | $17.80 |
| 09/30/2020 | OMEROS CORP | OMER | 0 | -87,852 | 0 | -1,293,000 | |
| 06/30/2020 | OMEROS CORP | OMER | 87,852 | 37,389 | 1,293,000 | 618,000 | $14.72 |
| 03/31/2020 | OMEROS CORP | OMER | 50,463 | 50,463 | 675,000 | 675,000 | $13.38 |
| 09/30/2017 | OMEROS CORP | OMER | 0 | -87,319 | 0 | -1,738,000 | |
| 06/30/2017 | OMEROS CORP | OMER | 87,319 | 87,319 | 1,738,000 | 1,738,000 | $19.90 |
| 06/30/2015 | OMEROS CORP | OMER | 0 | -23,900 | 0 | -527,000 | |
| 03/31/2015 | OMEROS CORP | OMER | 23,900 | 23,900 | 527,000 | 527,000 | $22.05 |
| 12/31/2014 | OMEROS CORP | OMER | 81,889 | 81,889 | 2,029,000 | 2,029,000 | $24.78 |
| 09/30/2014 | OMEROS CORP | OMER | 0 | -66,315 | 0 | -1,153,000 | |
| 06/30/2014 | OMEROS CORP | OMER | 66,315 | 66,315 | 1,154,000 | 1,154,000 | $17.40 |
| 12/31/2013 | OMEROS CORP | OMER | 0 | -12,600 | 0 | -123,000 | |
| 09/30/2013 | OMEROS CORP | OMER | 12,600 | 12,600 | 123,000 | 123,000 | $9.76 |
| 12/31/2012 | OMEROS CORP | OMER | 0 | -84,471 | 0 | -794,000 | |
| 09/30/2012 | OMEROS CORP | OMER | 84,471 | 496 | 794,000 | -46,000 | $9.40 |
| 06/30/2012 | OMEROS CORP | OMER | 83,975 | 83,975 | 840,000 | 840,000 | $10.00 |
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