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Manalapan Oracle Capital Management LLC
> ISIS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 09/30/2012 | IONIS PHARMACEUTICALS INC | ISIS | 94,895 | -184,496 | 1,335,000 | -2,018,000 | $14.07 |
| 06/30/2012 | IONIS PHARMACEUTICALS INC | ISIS | 279,391 | -35,478 | 3,353,000 | 592,000 | $12.00 |
| 03/31/2012 | IONIS PHARMACEUTICALS INC | ISIS | 314,869 | 53,380 | 2,761,000 | 876,000 | $8.77 |
| 12/31/2011 | IONIS PHARMACEUTICALS INC | ISIS | 261,489 | -70,000 | 1,885,000 | -362,000 | $7.21 |
| 09/30/2011 | IONIS PHARMACEUTICALS INC | ISIS | 331,489 | -111,107 | 2,247,000 | -1,807,000 | $6.78 |
| 06/30/2011 | IONIS PHARMACEUTICALS INC | ISIS | 442,596 | -60,531 | 4,054,000 | -494,000 | $9.16 |
| 03/31/2011 | IONIS PHARMACEUTICALS INC | ISIS | 503,127 | 63,366 | 4,548,000 | 98,000 | $9.04 |
| 12/31/2010 | IONIS PHARMACEUTICALS INC | ISIS | 439,761 | -40,617 | 4,450,000 | 415,000 | $10.12 |
| 09/30/2010 | IONIS PHARMACEUTICALS INC | ISIS | 480,378 | -94,097 | 4,035,000 | -1,463,000 | $8.40 |
| 06/30/2010 | IONIS PHARMACEUTICALS INC | ISIS | 574,475 | 75,566 | 5,498,000 | 45,000 | $9.57 |
| 03/31/2010 | IONIS PHARMACEUTICALS INC | ISIS | 498,909 | 16,105 | 5,453,000 | 89,000 | $10.93 |
| 12/31/2009 | IONIS PHARMACEUTICALS INC | ISIS | 482,804 | 482,804 | 5,364,000 | 5,364,000 | $11.11 |
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