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GEODE CAPITAL MANAGEMENT, LLC
> CRXX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2010 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 231,759 | 5,951 | 336,000 | 67,000 | $1.45 |
| 03/31/2010 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 225,808 | 196,532 | 269,000 | 245,000 | $1.19 |
| 12/31/2009 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 29,276 | 0 | 24,000 | -17,000 | $0.82 |
| 09/30/2009 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 29,276 | 0 | 41,000 | 17,000 | $1.40 |
| 06/30/2009 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 29,276 | 699 | 24,000 | 6,000 | $0.82 |
| 03/31/2009 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 28,577 | -233 | 18,000 | 0 | $0.63 |
| 12/31/2008 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 28,810 | 1,627 | 18,000 | -70,000 | $0.62 |
| 09/30/2008 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 27,183 | -945 | 88,000 | -12,000 | $3.24 |
| 06/30/2008 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 28,128 | 1,368 | 100,000 | 8,000 | $3.56 |
| 03/31/2008 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 26,760 | 2,032 | 92,000 | -18,000 | $3.44 |
| 12/31/2007 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 24,728 | -109 | 110,000 | -43,000 | $4.45 |
| 09/30/2007 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 24,837 | -331 | 153,000 | -2,000 | $6.16 |
| 06/30/2007 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 25,168 | 244 | 155,000 | -19,000 | $6.16 |
| 03/31/2007 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 24,924 | 518 | 174,000 | -37,000 | $6.98 |
| 12/31/2006 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 24,406 | 190 | 211,000 | 60,000 | $8.65 |
| 09/30/2006 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 24,216 | 159 | 151,000 | -60,000 | $6.24 |
| 06/30/2006 | EPIRUS Biopharmaceuticals, Inc. | CRXX | 24,057 | 24,057 | 211,000 | 211,000 | $8.77 |
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