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FMR LLC
> XENE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Xenon Pharmaceuticals Inc. | XENE | 5,188,707 | 460,858 | 199,765,220,000 | 30,555,504,000 | $38,500.00 |
| 03/31/2023 | Xenon Pharmaceuticals Inc. | XENE | 4,727,849 | 58,090 | 169,209,716,000 | 169,041,138,000 | $35,790.00 |
| 09/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 4,669,759 | 97,391 | 168,578,000 | 29,487,000 | $36.10 |
| 06/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 4,572,368 | 738,892 | 139,091,000 | 21,901,000 | $30.42 |
| 03/31/2022 | Xenon Pharmaceuticals Inc. | XENE | 3,833,476 | -76,541 | 117,190,000 | -4,959,000 | $30.57 |
| 12/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 3,910,017 | 853,261 | 122,149,000 | 75,442,000 | $31.24 |
| 09/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 3,056,756 | -15,688 | 46,707,000 | -10,502,000 | $15.28 |
| 06/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 3,072,444 | -14,800 | 57,209,000 | 1,947,000 | $18.62 |
| 03/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 3,087,244 | 461,692 | 55,262,000 | 14,881,000 | $17.90 |
| 02/08/2021 | Xenon Pharmaceuticals Inc. | XENE | 2,625,552 | 0 | 43,426,630 | 3,045,630 | $16.54 |
| 12/31/2020 | Xenon Pharmaceuticals Inc. | XENE | 2,625,552 | 932 | 40,381,000 | 11,326,000 | $15.38 |
| 09/30/2020 | Xenon Pharmaceuticals Inc. | XENE | 2,624,620 | 425,566 | 29,055,000 | 1,479,000 | $11.07 |
| 06/30/2020 | Xenon Pharmaceuticals Inc. | XENE | 2,199,054 | 611,518 | 27,576,000 | 9,573,000 | $12.54 |
| 03/31/2020 | Xenon Pharmaceuticals Inc. | XENE | 1,587,536 | 1,587,536 | 18,003,000 | 18,003,000 | $11.34 |
| 09/30/2016 | Xenon Pharmaceuticals Inc. | XENE | 0 | -910,920 | 0 | -7,324,000 | |
| 03/31/2016 | Xenon Pharmaceuticals Inc. | XENE | 0 | -910,920 | 0 | -7,324,000 | |
| 12/31/2015 | Xenon Pharmaceuticals Inc. | XENE | 910,920 | 0 | 7,324,000 | -200,000 | $8.04 |
| 09/30/2015 | Xenon Pharmaceuticals Inc. | XENE | 910,920 | -230,142 | 7,524,000 | -5,633,000 | $8.26 |
| 06/30/2015 | Xenon Pharmaceuticals Inc. | XENE | 1,141,062 | -115,177 | 13,157,000 | -8,027,000 | $11.53 |
| 03/31/2015 | Xenon Pharmaceuticals Inc. | XENE | 1,256,239 | 0 | 21,184,000 | -3,627,000 | $16.86 |
| 12/31/2014 | Xenon Pharmaceuticals Inc. | XENE | 1,256,239 | 1,256,239 | 24,811,000 | 24,811,000 | $19.75 |
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