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FMR LLC
> SAGE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Sage Therapeutics, Inc. | SAGE | 8,789,737 | 1,706,204 | 413,293,429,000 | 116,068,390,000 | $47,020.00 |
| 03/31/2023 | Sage Therapeutics, Inc. | SAGE | 7,083,533 | 765,999 | 297,225,039,000 | 296,977,644,000 | $41,960.00 |
| 09/30/2022 | Sage Therapeutics, Inc. | SAGE | 6,317,534 | 340,441 | 247,395,000 | 54,335,000 | $39.16 |
| 06/30/2022 | Sage Therapeutics, Inc. | SAGE | 5,977,093 | 345,568 | 193,060,000 | 6,657,000 | $32.30 |
| 03/31/2022 | Sage Therapeutics, Inc. | SAGE | 5,631,525 | 140,951 | 186,403,000 | -47,167,000 | $33.10 |
| 12/31/2021 | Sage Therapeutics, Inc. | SAGE | 5,490,574 | -146,510 | 233,570,000 | -16,210,000 | $42.54 |
| 09/30/2021 | Sage Therapeutics, Inc. | SAGE | 5,637,084 | -1,224,575 | 249,780,000 | -140,030,000 | $44.31 |
| 06/30/2021 | Sage Therapeutics, Inc. | SAGE | 6,861,659 | -1,895,630 | 389,810,000 | -265,673,000 | $56.81 |
| 03/31/2021 | Sage Therapeutics, Inc. | SAGE | 8,757,289 | 950,590 | 655,483,000 | -19,874,000 | $74.85 |
| 02/08/2021 | Sage Therapeutics, Inc. | SAGE | 7,806,699 | 0 | 645,692,074 | -29,664,926 | $82.71 |
| 12/31/2020 | Sage Therapeutics, Inc. | SAGE | 7,806,699 | 10,559 | 675,357,000 | 198,857,000 | $86.51 |
| 09/30/2020 | Sage Therapeutics, Inc. | SAGE | 7,796,140 | 8,468 | 476,500,000 | 152,689,000 | $61.12 |
| 06/30/2020 | Sage Therapeutics, Inc. | SAGE | 7,787,672 | 1,004 | 323,811,000 | 100,178,000 | $41.58 |
| 03/31/2020 | Sage Therapeutics, Inc. | SAGE | 7,786,668 | 14,039 | 223,633,000 | -337,473,000 | $28.72 |
| 12/31/2019 | Sage Therapeutics, Inc. | SAGE | 7,772,629 | 24,081 | 561,106,000 | -525,938,000 | $72.19 |
| 09/30/2019 | Sage Therapeutics, Inc. | SAGE | 7,748,548 | 76,394 | 1,087,044,000 | -317,651,000 | $140.29 |
| 06/30/2019 | Sage Therapeutics, Inc. | SAGE | 7,672,154 | 63,915 | 1,404,695,000 | 194,604,000 | $183.09 |
| 03/31/2019 | Sage Therapeutics, Inc. | SAGE | 7,608,239 | 575,163 | 1,210,091,000 | 536,393,000 | $159.05 |
| 12/31/2018 | Sage Therapeutics, Inc. | SAGE | 7,033,076 | 33,432 | 673,698,000 | -315,002,000 | $95.79 |
| 09/30/2018 | Sage Therapeutics, Inc. | SAGE | 6,999,644 | 22,266 | 988,700,000 | -103,469,000 | $141.25 |
| 06/30/2018 | Sage Therapeutics, Inc. | SAGE | 6,977,378 | 110,687 | 1,092,169,000 | -13,850,000 | $156.53 |
| 03/31/2018 | Sage Therapeutics, Inc. | SAGE | 6,866,691 | 629,172 | 1,106,019,000 | 78,638,000 | $161.07 |
| 12/31/2017 | Sage Therapeutics, Inc. | SAGE | 6,237,519 | 621,357 | 1,027,381,000 | 677,495,000 | $164.71 |
| 09/30/2017 | Sage Therapeutics, Inc. | SAGE | 5,616,162 | 14,219 | 349,886,000 | 349,439,861 | $62.30 |
| 06/30/2017 | Sage Therapeutics, Inc. | SAGE | 5,601,943 | 11,416 | 446,139 | -396,872,861 | $0.08 |
| 03/31/2017 | Sage Therapeutics, Inc. | SAGE | 5,590,527 | 15,451 | 397,319,000 | 112,656,000 | $71.07 |
| 12/31/2016 | Sage Therapeutics, Inc. | SAGE | 5,575,076 | 100,596 | 284,663,000 | 32,563,000 | $51.06 |
| 09/30/2016 | Sage Therapeutics, Inc. | SAGE | 5,474,480 | 5,474,480 | 252,100,000 | 252,100,000 | $46.05 |
| 06/30/2016 | Sage Therapeutics, Inc. | SAGE | 4,804,432 | 6,204 | 144,758,000 | -9,073,000 | $30.13 |
| 03/31/2016 | Sage Therapeutics, Inc. | SAGE | 4,798,228 | 469,958 | 153,831,000 | -98,507,000 | $32.06 |
| 12/31/2015 | Sage Therapeutics, Inc. | SAGE | 4,328,270 | 6,281 | 252,338,000 | 69,431,000 | $58.30 |
| 09/30/2015 | Sage Therapeutics, Inc. | SAGE | 4,321,989 | 57,500 | 182,907,000 | -128,401,000 | $42.32 |
| 06/30/2015 | Sage Therapeutics, Inc. | SAGE | 4,264,489 | 393,186 | 311,308,000 | 116,852,000 | $73.00 |
| 03/31/2015 | Sage Therapeutics, Inc. | SAGE | 3,871,303 | 2,410 | 194,456,000 | 52,855,000 | $50.23 |
| 12/31/2014 | Sage Therapeutics, Inc. | SAGE | 3,868,893 | 12,104 | 141,601,000 | 20,112,000 | $36.60 |
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