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RAINIER INVESTMENT MANAGEMENT LLC
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 23,050 | -40,390 | 1,159,000 | -2,057,000 | $50.28 |
| 09/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 63,440 | -13,490 | 3,216,000 | -697,000 | $50.69 |
| 06/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 76,930 | -31,110 | 3,913,000 | -430,000 | $50.86 |
| 03/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 108,040 | 7,850 | 4,343,000 | -448,000 | $40.20 |
| 12/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 100,190 | -34,260 | 4,791,000 | -135,000 | $47.82 |
| 09/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 134,450 | 134,450 | 4,926,000 | 4,926,000 | $36.64 |
| 06/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 154,490 | -6,420 | 3,598,000 | -2,918,000 | $23.29 |
| 03/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 160,910 | 160,910 | 6,516,000 | 6,516,000 | $40.49 |
| 12/31/2015 | IONIS PHARMACEUTICALS INC | IONS | 127,030 | 127,030 | 7,866,000 | 7,866,000 | $61.92 |
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