| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/17/2023 | Syros Pharmaceuticals, Inc. | SYRS | Sale | Common Stock | 689 | $3.50 | $2.4k | | 07/17/2023 |
| 04/03/2023 | Syros Pharmaceuticals, Inc. | SYRS | Payment of Exercise | Common Stock | 623 | $2.58 | $1.6k | | 03/31/2023 |
| 03/31/2023 | Syros Pharmaceuticals, Inc. | SYRS | Exercise | Restricted Stock Units | 2k | $0.00 | $0 | | 03/31/2023 |
| 10/06/2022 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 44.5k | $6.73 | $299.5k | | 10/06/2022 |
| 10/06/2022 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Restricted Stock Units | 34k | $0.00 | $0 | | 10/06/2022 |
| 04/01/2022 | Syros Pharmaceuticals, Inc. | SYRS | Payment of Exercise | Common Stock | 27.3k | $1.12 | $30.5k | | 04/01/2022 |
| 02/15/2022 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 100k | $1.59 | $159k | | 02/15/2022 |
| 02/15/2022 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Restricted Stock Units | 80k | $0.00 | $0 | | 02/15/2022 |
| 02/15/2022 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Restricted Stock Units | 200k | $0.00 | $0 | | 02/15/2022 |
| 01/05/2022 | Syros Pharmaceuticals, Inc. | SYRS | Sale | Common Stock | 2.2k | $3.47 | $7.7k | | 01/05/2022 |
| 03/15/2021 | Syros Pharmaceuticals, Inc. | SYRS | Sale | Common Stock | 3.6k | $9.47 | $34.4k | | 03/15/2021 |
| 03/15/2021 | Syros Pharmaceuticals, Inc. | SYRS | Exercise | Stock Option (right to buy) | 3.6k | $1.01 | $3.7k | | 03/15/2021 |
| 02/17/2021 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 94k | $11.41 | $1.1M | | 02/17/2021 |
| 08/18/2020 | Syros Pharmaceuticals, Inc. | SYRS | Sale | Common Stock | 10.8k | $13.00 | $140.2k | | 08/17/2020 |
| 08/18/2020 | Syros Pharmaceuticals, Inc. | SYRS | Exercise | Stock Option (right to buy) | 10.8k | $1.01 | $10.9k | | 08/17/2020 |
| 08/17/2020 | Syros Pharmaceuticals, Inc. | SYRS | Exercise | Stock Option (right to buy) | 5k | $1.01 | $5k | | 08/17/2020 |
| 08/17/2020 | Syros Pharmaceuticals, Inc. | SYRS | Sale | Common Stock | 5k | $13.00 | $64.5k | | 08/17/2020 |
| 07/07/2020 | Syros Pharmaceuticals, Inc. | SYRS | Sale | Common Stock | 1.8k | $11.72 | $20.5k | | 07/07/2020 |
| 02/18/2020 | Syros Pharmaceuticals, Inc. | SYRS | Sale | Common Stock | 1.4k | $7.38 | $10.7k | | 02/18/2020 |
| 02/13/2020 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 94k | $7.54 | $708.8k | | 02/13/2020 |
| 02/12/2019 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Common Stock | 87k | $0.00 | $0 | | 02/12/2019 |
| 02/12/2019 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 75k | $6.71 | $503.2k | | 02/12/2019 |
| 02/16/2018 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 75k | $10.09 | $756.8k | | 02/16/2018 |