| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 11/16/2022 | LogicBio Therapeutics, Inc. | LOGC | Disposition | Common Stock | 3.9k | $0.00 | $0 | | 11/16/2022 |
| 11/16/2022 | LogicBio Therapeutics, Inc. | LOGC | Disposition | Stock Option (right to buy) | 12.5k | $0.38 | $4.8k | | 11/16/2022 |
| 06/17/2022 | LogicBio Therapeutics, Inc. | LOGC | Grant | Stock Option (right to buy) | 12.5k | $0.38 | $4.8k | | 06/17/2022 |
| 06/11/2021 | LogicBio Therapeutics, Inc. | LOGC | Grant | Stock Option (right to buy) | 12.5k | $4.59 | $57.4k | | 06/11/2021 |
| 01/01/2021 | LogicBio Therapeutics, Inc. | LOGC | Exercise | Restricted Stock Units | 3.9k | $0.00 | $0 | | 01/01/2021 |
| 06/19/2020 | LogicBio Therapeutics, Inc. | LOGC | Grant | Stock Option (right to buy) | 10k | $7.96 | $79.6k | | 06/19/2020 |
| 06/19/2020 | LogicBio Therapeutics, Inc. | LOGC | Grant | Restricted Stock Units | 3.9k | $0.00 | $0 | | 06/19/2020 |
| 12/19/2019 | LogicBio Therapeutics, Inc. | LOGC | Grant | Stock Option (right to buy) | 10.9k | $12.65 | $137.5k | | 12/19/2019 |
| 06/14/2019 | AKCEA THERAPEUTICS, INC. | AKCA | Grant | Stock Option (right to buy) | 26.4k | $22.74 | $600.3k | | 06/14/2019 |
| 10/18/2018 | LogicBio Therapeutics, Inc. | LOGC | Grant | Stock Option (right to buy) | 24.1k | $10.00 | $241k | | 10/18/2018 |
| 06/01/2018 | AKCEA THERAPEUTICS, INC. | AKCA | Grant | Stock Option (right to buy) | 53k | $23.46 | $1.2M | | 06/01/2018 |
| 06/01/2018 | AKCEA THERAPEUTICS, INC. | AKCA | Grant | Stock Option (right to buy) | 26.4k | $23.46 | $619.3k | | 06/01/2018 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 23k | $58.66 | $1.4M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 24.2k | $68.48 | $1.7M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 24.2k | $62.16 | $1.5M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 48.5k | $58.50 | $2.8M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 48.5k | $62.98 | $3.1M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 57k | $43.90 | $2.5M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 45k | $46.24 | $2.1M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 830 | $41.50 | $34.4k | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 80.3k | $32.52 | $2.6M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 13.3k | $32.52 | $432.2k | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 41k | $53.47 | $2.2M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 10k | $43.30 | $433k | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Other | Genzyme common stock (GENZ) | 218 | $74.00 | $16.1k | By 401(k) | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Other | Genzyme common stock (GENZ) | 20.8k | $74.00 | $1.5M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Genzyme common stock (GENZ) | 15.8k | $74.00 | $1.2M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Disposition | Stock Option (right to buy) | 23k | $51.52 | $1.2M | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Exercise | Restricted Stock Units | 8.1k | $0.00 | $0 | | 04/04/2011 |
| 04/04/2011 | GENZYME CORP | GENZ | Exercise | Restricted Stock Units | 7.7k | $0.00 | $0 | | 04/04/2011 |
| 05/14/2010 | GENZYME CORP | GENZ | Sale | Genzyme common stock (GENZ) | 18.3k | $50.70 | $928.7k | | 05/14/2010 |
| 05/14/2010 | GENZYME CORP | GENZ | Exercise | Stock Option (right to buy) | 18.3k | $26.50 | $485.4k | | 05/14/2010 |