| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/09/2023 | Kelly Liam | Chairman, President & CEO | Gift | Common Stock | 5.8k | $0.00 | $0 | | 08/09/2023 |
| 08/09/2023 | Kelly Liam | Chairman, President & CEO | Gift | Common Stock | 5.8k | $0.00 | $0 | By Spouse | 08/09/2023 |
| 05/10/2023 | RANDLE STUART A | Director | Sale | Common Stock | 3k | $245.71 | $742.3k | | 05/09/2023 |
| 05/10/2023 | RANDLE STUART A | Director | Exercise | Stock Option / (Right to Buy) | 3k | $101.12 | $305.5k | | 05/09/2023 |
| 05/09/2023 | RANDLE STUART A | Director | Grant | Stock Option / (Right to Buy) | 1.1k | $251.99 | $271.1k | | 05/09/2023 |
| 05/09/2023 | RANDLE STUART A | Director | Grant | Common Stock | 527 | $0.00 | $0 | | 05/09/2023 |
| 05/09/2023 | HAGGERTY GRETCHEN R | Director | Grant | Common Stock | 527 | $0.00 | $0 | | 05/09/2023 |
| 05/09/2023 | HAGGERTY GRETCHEN R | Director | Grant | Stock Option / (Right to Buy) | 1.1k | $251.99 | $271.1k | | 05/09/2023 |
| 05/09/2023 | Klasko Stephen K. M.D. | Director | Grant | Common Stock | 681 | $0.00 | $0 | | 05/09/2023 |
| 05/09/2023 | Klasko Stephen K. M.D. | Director | Grant | Stock Option / (Right to Buy) | 1.1k | $251.99 | $271.1k | | 05/09/2023 |
| 05/09/2023 | HEINMILLER JOHN C | Director | Grant | Common Stock | 527 | $0.00 | $0 | | 05/09/2023 |
| 05/09/2023 | HEINMILLER JOHN C | Director | Grant | Stock Option / (Right to Buy) | 1.1k | $251.99 | $271.1k | | 05/09/2023 |
| 05/09/2023 | Krakauer Andrew A | Director | Grant | Common Stock | 527 | $0.00 | $0 | | 05/09/2023 |
| 05/09/2023 | Krakauer Andrew A | Director | Grant | Stock Option / (Right to Buy) | 1.1k | $251.99 | $271.1k | | 05/09/2023 |
| 05/09/2023 | Duncan Candace H | Director | Grant | Common Stock | 527 | $0.00 | $0 | | 05/09/2023 |
| 05/09/2023 | Duncan Candace H | Director | Grant | Stock Option / (Right to Buy) | 1.1k | $251.99 | $271.1k | | 05/09/2023 |
| 05/09/2023 | Patil Neena M | Director | Grant | Common Stock | 527 | $0.00 | $0 | | 05/09/2023 |
| 05/09/2023 | Patil Neena M | Director | Grant | Stock Option / (Right to Buy) | 1.1k | $251.99 | $271.1k | | 05/09/2023 |
| 05/09/2023 | Ryu Jaewon | Director | Grant | Common Stock | 527 | $0.00 | $0 | | 05/09/2023 |
| 05/09/2023 | Ryu Jaewon | Director | Grant | Stock Option / (Right to Buy) | 2.2k | $251.99 | $542.3k | | 05/09/2023 |
| 02/28/2023 | Logue Daniel V. | CVP, General Counsel & Secty | Grant | Common Stock | 1.1k | $0.00 | $0 | | 02/25/2023 |
| 02/28/2023 | Logue Daniel V. | CVP, General Counsel & Secty | Grant | Stock Option / (Right to Buy) | 7.9k | $238.23 | $1.9M | | 02/25/2023 |
| 02/28/2023 | White Jay | CVP & Pres, Global Commercial | Grant | Common Stock | 1.3k | $0.00 | $0 | | 02/25/2023 |
| 02/28/2023 | White Jay | CVP & Pres, Global Commercial | Grant | Stock Option / (Right to Buy) | 9.4k | $238.23 | $2.2M | | 02/25/2023 |
| 02/28/2023 | Winters James | Corp VP, Mfg and Supply | Grant | Common Stock | 912 | $0.00 | $0 | | 02/25/2023 |
| 02/28/2023 | Winters James | Corp VP, Mfg and Supply | Grant | Stock Option / (Right to Buy) | 6.4k | $238.23 | $1.5M | | 02/25/2023 |
| 02/28/2023 | Deren John | Corp. VP & CAO | Grant | Common Stock | 414 | $0.00 | $0 | | 02/25/2023 |
| 02/28/2023 | Deren John | Corp. VP & CAO | Grant | Stock Option / (Right to Buy) | 2.9k | $238.23 | $687.5k | | 02/25/2023 |
| 02/28/2023 | Hicks Cameron P | Corp. VP & Chief HR Officer | Grant | Common Stock | 906 | $0.00 | $0 | | 02/25/2023 |
| 02/28/2023 | Hicks Cameron P | Corp. VP & Chief HR Officer | Grant | Stock Option / (Right to Buy) | 6.3k | $238.23 | $1.5M | | 02/25/2023 |
| 02/28/2023 | POWELL THOMAS E | Executive Vice President & CFO | Grant | Common Stock | 2.4k | $0.00 | $0 | | 02/25/2023 |
| 02/28/2023 | POWELL THOMAS E | Executive Vice President & CFO | Grant | Stock Option / (Right to Buy) | 16.4k | $238.23 | $3.9M | | 02/25/2023 |
| 02/28/2023 | Kelly Liam | Chairman, President & CEO | Grant | Common Stock | 5k | $0.00 | $0 | | 02/25/2023 |
| 02/28/2023 | Kelly Liam | Chairman, President & CEO | Grant | Stock Option / (Right to Buy) | 46.9k | $238.23 | $11.2M | | 02/25/2023 |
| 02/25/2023 | Kelly Liam | Chairman, President & CEO | Payment of Exercise | Common Stock | 1k | $235.18 | $241.1k | | 02/25/2023 |
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