| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/18/2023 | Annovis Bio, Inc. | ANVS | Grant | Stock Option (right to buy) | 6.8k | $13.17 | $89.8k | | 01/18/2023 |
| 01/04/2022 | Annovis Bio, Inc. | ANVS | Payment of Exercise | Common Stock | 6.7k | $19.78 | $131.7k | | 01/03/2022 |
| 01/04/2022 | Annovis Bio, Inc. | ANVS | Exercise | Stock Option (right to buy) | 30k | $4.39 | $131.7k | | 01/03/2022 |
| 01/04/2022 | Annovis Bio, Inc. | ANVS | Exercise | Stock Option (right to buy) | 7.1k | $0.25 | $1.8k | | 01/03/2022 |
| 01/04/2022 | Annovis Bio, Inc. | ANVS | Payment of Exercise | Common Stock | 90 | $19.78 | $1.8k | | 01/03/2022 |
| 01/03/2022 | Annovis Bio, Inc. | ANVS | Grant | Stock Option (right to buy) | 9k | $19.78 | $178k | | 01/03/2022 |
| 07/07/2021 | Annovis Bio, Inc. | ANVS | Grant | Stock Option (right to buy) | 4.5k | $102.85 | $462.8k | | 07/07/2021 |
| 08/27/2020 | Onconova Therapeutics, Inc. | ONTX | Sale | Common Stock | 182.5k | $0.27 | $49.6k | By the Michael and Jane Hoffman 2013 Descendants Trust | 08/27/2020 |
| 08/27/2020 | Onconova Therapeutics, Inc. | ONTX | Sale | Common Stock | 1.9k | $0.27 | $510.1 | | 08/27/2020 |
| 07/01/2020 | Annovis Bio, Inc. | ANVS | Grant | Stock Option (right to buy) | 30k | $4.39 | $131.7k | | 07/01/2020 |
| 01/31/2020 | Annovis Bio, Inc. | ANVS | Purchase | Common Stock | 33.3k | $6.00 | $200k | | 01/31/2020 |
| 01/31/2020 | Annovis Bio, Inc. | ANVS | Conversion | Common Stock | 158.7k | $0.00 | $0 | | 01/31/2020 |
| 01/31/2020 | Annovis Bio, Inc. | ANVS | Conversion | Common Stock | 1.1M | $0.00 | $0 | | 01/31/2020 |
| 01/31/2020 | Annovis Bio, Inc. | ANVS | Conversion | Common Stock | 55.9k | $4.80 | $268.2k | | 01/31/2020 |
| 01/31/2020 | Annovis Bio, Inc. | ANVS | Conversion | Series A-1 Preferred Stock | 222.2k | $0.00 | $0 | | 01/31/2020 |
| 01/31/2020 | Annovis Bio, Inc. | ANVS | Conversion | Series A Preferred Stock | 1.6M | $0.00 | $0 | | 01/31/2020 |
| 01/31/2020 | Annovis Bio, Inc. | ANVS | Conversion | Convertible Note | 55.9k | $4.80 | $268.2k | | 01/31/2020 |
| 07/26/2019 | Onconova Therapeutics, Inc. | ONTX | Grant | Stock Option (right to purchase) | 5.8k | $3.39 | $19.8k | | 07/26/2019 |
| 08/29/2018 | Onconova Therapeutics, Inc. | ONTX | Sale | Common Stock | 30k | $0.45 | $13.5k | By the Michael and Jane Hoffman 2018 Descendants Trust | 08/27/2018 |
| 08/28/2018 | Onconova Therapeutics, Inc. | ONTX | Sale | Common Stock | 30k | $0.46 | $13.7k | By the Michael and Jane Hoffman 2018 Descendants Trust | 08/27/2018 |
| 08/28/2018 | Onconova Therapeutics, Inc. | ONTX | Sale | Common Stock | 20k | $0.44 | $8.9k | By the Michael and Jane Hoffman 2018 Descendants Trust | 08/27/2018 |
| 08/27/2018 | Onconova Therapeutics, Inc. | ONTX | Sale | Common Stock | 20k | $0.45 | $9.1k | By the Michael and Jane Hoffman 2018 Descendants Trust | 08/27/2018 |
| 07/26/2018 | Onconova Therapeutics, Inc. | ONTX | Grant | Stock Option (right to purchase) | 87.5k | $0.46 | $40.2k | | 07/26/2018 |
| 04/27/2018 | Onconova Therapeutics, Inc. | ONTX | Purchase | Warrant (right to purchase) | 2.2M | $0.43 | $940k | By the Michael and Jane Hoffman 2013 Descendants Trust | 04/27/2018 |
| 04/27/2018 | Onconova Therapeutics, Inc. | ONTX | Purchase | Common Stock | 2.2M | $0.00 | $0 | By the Michael and Jane Hoffman 2013 Descendants Trust | 04/27/2018 |
| 06/12/2017 | Onconova Therapeutics, Inc. | ONTX | Grant | Stock Option (right to purchase) | 2k | $1.94 | $3.9k | | 06/12/2017 |
| 07/30/2013 | Onconova Therapeutics, Inc. | ONTX | Conversion | Series G Convertible Preferred Stock | 229.8k | $0.00 | $0 | By The Michael and Jane Hoffman 2013 Descendants Trust | 07/30/2013 |
| 07/30/2013 | Onconova Therapeutics, Inc. | ONTX | Conversion | Series H COnvertible Preferred Stock | 301.3k | $0.00 | $0 | By The Michael and Jane Hoffman 2013 Descendants Trust | 07/30/2013 |
| 07/30/2013 | Onconova Therapeutics, Inc. | ONTX | Conversion | Series I Convertible Preferred Stock | 1.6M | $0.00 | $0 | By The Michael and Jane Hoffman 2013 Descendants Trust | 07/30/2013 |
| 07/30/2013 | Onconova Therapeutics, Inc. | ONTX | Conversion | Common Stock | 83.9k | $0.00 | $0 | By The Michael and Jane Hoffman 2013 Descendants Trust | 07/30/2013 |
| 07/30/2013 | Onconova Therapeutics, Inc. | ONTX | Conversion | Common Stock | 105.4k | $0.00 | $0 | By The Michael and Jane Hoffman 2013 Descendants Trust | 07/30/2013 |
| 07/30/2013 | Onconova Therapeutics, Inc. | ONTX | Conversion | Common Stock | 266.7k | $0.00 | $0 | By The Michael and Jane Hoffman 2013 Descendants Trust | 07/30/2013 |
| 07/30/2013 | Onconova Therapeutics, Inc. | ONTX | Conversion | Common Stock | 476.1k | $0.00 | $0 | By The Michael and Jane Hoffman 2013 Descendants Trust | 07/30/2013 |
| 07/30/2013 | Onconova Therapeutics, Inc. | ONTX | Conversion | Common Stock | 85.7k | $0.00 | $0 | By The Michael and Jane Hoffman 2013 Descendants Trust | 07/30/2013 |
| 07/30/2013 | Onconova Therapeutics, Inc. | ONTX | Conversion | Common Stock | 84.5k | $0.00 | $0 | By The Michael and Jane Hoffman 2013 Descendants Trust (Non-GST Exempt Trust) | 07/30/2013 |
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