| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 05/24/2023 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Grant | Stock Option (right to buy) | 25.8k | $11.94 | $307.8k | | 05/24/2023 |
| 03/15/2023 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Sale | Common Stock | 7.5k | $8.90 | $67.1k | | 03/15/2023 |
| 03/15/2023 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Exercise | Stock Option (right to buy) | 25k | $2.54 | $63.5k | | 03/15/2023 |
| 05/25/2022 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Grant | Stock Option (right to buy) | 63k | $5.37 | $338.4k | | 05/25/2022 |
| 03/17/2022 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Other (disposition) | Common Stock | 4.8M | $0.00 | $0 | MDV VII LP, nom for MDV VII LP, MDV VII Leaders' Fund LP, MDV ENF VII (A) LP, and MDV ENF VII (B) LP | 02/12/2021 |
| 03/17/2022 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Other (acquisition) | Common Stock | 1.3k | $0.00 | $0 | | 02/12/2021 |
| 11/24/2021 | Adamas Pharmaceuticals Inc | ADMS | Other | Common Stock | 10k | $0.00 | $0 | | 11/24/2021 |
| 11/24/2021 | Adamas Pharmaceuticals Inc | ADMS | Other | Common Stock | 4M | $0.00 | $0 | MDV VII LP, nom for MDV VII LP, MDV VII Leaders' Fund LP, MDV ENF VII (A) LP, and MDV ENF VII (B) LP | 11/24/2021 |
| 11/24/2021 | Adamas Pharmaceuticals Inc | ADMS | Other | Common Stock | 6k | $0.00 | $0 | MDV ENF VII (A), L.P. | 11/24/2021 |
| 11/24/2021 | Adamas Pharmaceuticals Inc | ADMS | Other | Common Stock | 3.1k | $0.00 | $0 | MDV ENF VII (B), L.P. | 11/24/2021 |
| 11/24/2021 | Adamas Pharmaceuticals Inc | ADMS | Other | Common Stock | 25.7k | $0.00 | $0 | MDV VII Leaders' Fund, L.P. | 11/24/2021 |
| 11/24/2021 | Adamas Pharmaceuticals Inc | ADMS | Other | Common Stock | 288k | $0.00 | $0 | MDV IX, L.P., as nominee for MDV IX, L.P., and MDV ENF IX, L.P. | 11/24/2021 |
| 11/24/2021 | Adamas Pharmaceuticals Inc | ADMS | Other | Common Stock | 265.2k | $0.00 | $0 | MDV VII, L.P. | 11/24/2021 |
| 11/24/2021 | Adamas Pharmaceuticals Inc | ADMS | Disposition | Stock Option (Right to Buy) | 10k | $4.80 | $48k | | 11/24/2021 |
| 11/24/2021 | Adamas Pharmaceuticals Inc | ADMS | Disposition | Stock Option (Right to Buy) | 10k | $2.70 | $27k | | 11/24/2021 |
| 11/24/2021 | Adamas Pharmaceuticals Inc | ADMS | Disposition | Stock Option (Right to Buy) | 10k | $5.21 | $52.1k | | 11/24/2021 |
| 06/16/2021 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Grant | Stock Option (right to buy) | 12.9k | $27.90 | $359.5k | | 06/16/2021 |
| 06/02/2021 | Adamas Pharmaceuticals Inc | ADMS | Grant | Common Stock | 5k | $0.00 | $0 | | 06/02/2021 |
| 06/02/2021 | Adamas Pharmaceuticals Inc | ADMS | Grant | Stock Option (Right to Buy) | 10k | $5.21 | $52.1k | | 06/02/2021 |
| 05/25/2021 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Sale | Common Stock | 36.6k | $25.88 | $947.3k | | 05/25/2021 |
| 05/25/2021 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Sale | Common Stock | 900 | $26.42 | $23.8k | | 05/25/2021 |
| 05/25/2021 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Exercise | Stock Option (right to buy) | 12.5k | $10.58 | $132.2k | | 05/25/2021 |
| 05/25/2021 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Exercise | Stock Option (right to buy) | 25k | $1.83 | $45.8k | | 05/25/2021 |
| 02/12/2021 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Other (disposition) | Common Stock | 750k | $0.00 | $0 | MDV VII LP, nom for MDV VII LP, MDV VII Leaders' Fund LP, MDV ENF VII (A) LP, and MDV ENF VII (B) LP | 02/12/2021 |
| 02/12/2021 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Other (acquisition) | Common Stock | 68 | $0.00 | $0 | | 02/12/2021 |
| 08/04/2020 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Grant | Stock Option (right to buy) | 97.8k | $3.89 | $380.4k | | 08/04/2020 |
| 06/03/2020 | Adamas Pharmaceuticals Inc | ADMS | Grant | Common Stock | 5k | $0.00 | $0 | | 06/03/2020 |
| 06/03/2020 | Adamas Pharmaceuticals Inc | ADMS | Grant | Stock Option (Right to Buy) | 10k | $2.70 | $27k | | 06/03/2020 |
| 06/05/2019 | Adamas Pharmaceuticals Inc | ADMS | Grant | Stock Option (Right to Buy) | 10k | $4.80 | $48k | | 06/05/2019 |
| 06/06/2018 | Adamas Pharmaceuticals Inc | ADMS | Grant | Stock Option (Right to Buy) | 10k | $27.98 | $279.8k | | 06/06/2018 |
| 05/22/2018 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | Grant | Stock Option (right to buy) | 25k | $2.61 | $65.2k | | 05/22/2018 |
| 06/13/2017 | Rocket Fuel Inc. | FUEL | Grant | Employee Stock Option (right to buy) | 55.1k | $2.68 | $147.6k | | 06/13/2017 |
| 06/01/2017 | Adamas Pharmaceuticals Inc | ADMS | Grant | Stock Option (Right to Buy) | 15k | $16.27 | $244k | | 06/01/2017 |
| 09/16/2016 | Adamas Pharmaceuticals Inc | ADMS | Purchase | Common Stock | 8.2k | $16.81 | $138.5k | MDV VII LP, nom for MDV VII LP, MDV VII Leaders' Fund LP, MDV ENF VII (A) LP, and MDV ENF VII (B) LP | 09/14/2016 |
| 09/15/2016 | Adamas Pharmaceuticals Inc | ADMS | Purchase | Common Stock | 200 | $16.50 | $3.3k | MDV VII LP, nom for MDV VII LP, MDV VII Leaders' Fund LP, MDV ENF VII (A) LP, and MDV ENF VII (B) LP | 09/14/2016 |
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