| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/06/2023 | Akebia Therapeutics, Inc. | AKBA | Grant | Stock Option (Right to buy) | 45k | $1.20 | $54k | | 06/06/2023 |
| 06/06/2023 | Akebia Therapeutics, Inc. | AKBA | Grant | Common Stock | 30k | $0.00 | $0 | | 06/06/2023 |
| 07/15/2022 | ACELRX PHARMACEUTICALS INC | ACRX | Grant | | 15.5k | $0.00 | $0 | | 07/15/2022 |
| 07/15/2022 | ACELRX PHARMACEUTICALS INC | ACRX | Grant | Stock Option (Right to Buy) | 31k | $0.23 | $7.2k | | 07/15/2022 |
| 06/08/2022 | Akebia Therapeutics, Inc. | AKBA | Grant | Stock Option (Right to buy) | 20.1k | $0.45 | $9k | | 06/08/2022 |
| 06/08/2022 | Akebia Therapeutics, Inc. | AKBA | Grant | Common Stock | 13.7k | $0.00 | $0 | | 06/08/2022 |
| 01/26/2022 | IMPEL PHARMACEUTICALS INC | IMPL | Grant | Stock Option (right to buy) | 175k | $9.85 | $1.7M | | 01/26/2022 |
| 08/18/2021 | IMPEL PHARMACEUTICALS INC | IMPL | Purchase | Common Stock | 17.2k | $13.81 | $237.5k | | 08/18/2021 |
| 08/18/2021 | IMPEL PHARMACEUTICALS INC | IMPL | Purchase | Common Stock | 2.2k | $14.91 | $32.8k | | 08/18/2021 |
| 08/18/2021 | IMPEL PHARMACEUTICALS INC | IMPL | Purchase | Common Stock | 600 | $15.89 | $9.5k | | 08/18/2021 |
| 07/20/2021 | IMPEL PHARMACEUTICALS INC | IMPL | Grant | Stock Option (right to buy) | 50k | $12.16 | $608k | | 07/20/2021 |
| 06/17/2021 | ACELRX PHARMACEUTICALS INC | ACRX | Grant | | 10k | $0.00 | $0 | | 06/17/2021 |
| 06/17/2021 | ACELRX PHARMACEUTICALS INC | ACRX | Grant | Stock Option (Right to Buy) | 20k | $1.41 | $28.2k | | 06/17/2021 |
| 06/02/2021 | Akebia Therapeutics, Inc. | AKBA | Grant | Common Stock | 13.7k | $0.00 | $0 | | 06/02/2021 |
| 06/02/2021 | Akebia Therapeutics, Inc. | AKBA | Grant | Stock Option (Right to buy) | 20.1k | $3.37 | $67.7k | | 06/02/2021 |
| 06/16/2020 | ACELRX PHARMACEUTICALS INC | ACRX | Grant | | 7.5k | $0.00 | $0 | | 06/16/2020 |
| 06/16/2020 | ACELRX PHARMACEUTICALS INC | ACRX | Grant | Stock Option (Right to Buy) | 15k | $1.43 | $21.4k | | 06/16/2020 |
| 06/15/2020 | ACELRX PHARMACEUTICALS INC | ACRX | Purchase | Common Stock | 100k | $1.29 | $128.9k | | 06/15/2020 |
| 06/15/2020 | ACELRX PHARMACEUTICALS INC | ACRX | Purchase | Common Stock | 100k | $1.29 | $128.9k | | 06/15/2020 |
| 06/05/2020 | Akebia Therapeutics, Inc. | AKBA | Grant | Common Stock | 13.7k | $0.00 | $0 | | 06/05/2020 |
| 06/05/2020 | Akebia Therapeutics, Inc. | AKBA | Grant | Stock Option (Right to buy) | 20.1k | $11.96 | $240.4k | | 06/05/2020 |
| 11/20/2019 | Akebia Therapeutics, Inc. | AKBA | Purchase | Common Stock | 50k | $3.41 | $170.5k | | 11/20/2019 |
| 06/25/2019 | ACELRX PHARMACEUTICALS INC | ACRX | Grant | Stock Option (Right to Buy) | 7.5k | $2.19 | $16.4k | | 06/25/2019 |
| 06/25/2019 | ACELRX PHARMACEUTICALS INC | ACRX | Grant | | 3.8k | $0.00 | $0 | | 06/25/2019 |
| 06/06/2019 | Akebia Therapeutics, Inc. | AKBA | Grant | Common Stock | 13.7k | $0.00 | $0 | | 06/06/2019 |
| 06/06/2019 | Akebia Therapeutics, Inc. | AKBA | Grant | Stock Option (Right to buy) | 20.1k | $4.23 | $85k | | 06/06/2019 |
| 12/12/2018 | Akebia Therapeutics, Inc. | AKBA | Grant | Stock Option (Right to buy) | 25k | $8.94 | $223.5k | | 12/12/2018 |
| 06/14/2018 | ACELRX PHARMACEUTICALS INC | ACRX | Grant | Stock Options (Right to Buy) | 15k | $4.13 | $61.9k | | 06/14/2018 |
| 06/15/2017 | ACELRX PHARMACEUTICALS INC | ACRX | Grant | | 15k | $2.30 | $34.5k | | 06/15/2017 |
| 05/11/2017 | Aralez Pharmaceuticals Inc. | ARLZ | Grant | Common Shares, without par value | 218.4k | $0.00 | $0 | | 05/11/2017 |
| 05/11/2017 | Aralez Pharmaceuticals Inc. | ARLZ | Grant | Employee Stock Option (right to buy) | 252.3k | $1.56 | $393.6k | | 05/11/2017 |
| 03/15/2017 | Aralez Pharmaceuticals Inc. | ARLZ | Purchase | Common Shares, without par value | 500k | $2.46 | $1.2M | | 03/15/2017 |
| 06/21/2016 | ACELRX PHARMACEUTICALS INC | ACRX | Grant | | 15k | $2.87 | $43k | | 06/21/2016 |
| 03/17/2016 | Aralez Pharmaceuticals Inc. | ARLZ | Grant | Common Shares, without par value | 124.3k | $0.00 | $0 | | 03/17/2016 |
| 03/17/2016 | Aralez Pharmaceuticals Inc. | ARLZ | Grant | Stock Options (right to buy) | 105.3k | $3.80 | $400k | | 03/17/2016 |
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