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| In millions, except per share items | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Operating activities: | | | | | | | | |
| Net income | 1,728.1 | 1,066.8 | 1,381.8 | 1,125.0 | 670.9 | 738.3 | | |
| Adjustments to reconcile net income to net cash from operating activities: | | | | | | | | |
| Depreciation and loss on disposal of property, plant, and equipment | 282.8 | 226.4 | 160.0 | 108.6 | 86.2 | 73.9 | 65.1 | 52.0 |
| Amortization of intangible assets | 27.4 | 49.8 | 43.0 | 14.2 | 12.9 | 18.2 | 24.4 | 22.4 |
| Loss (gain) on investments, accretion, and amortization, net | 10.6 | -55.1 | -6.0 | 1.8 | 21.2 | 35.9 | 26.4 | 33.9 |
| Deferred income taxes | -62.6 | 57.6 | -8.0 | 31.9 | 60.2 | 20.9 | 4.6 | -35.0 |
| Share-based compensation expense | 449.2 | 395.4 | 335.8 | 261.2 | 209.1 | 177.6 | 167.9 | 168.9 |
| Amortization of contract acquisition assets | 22.0 | 17.1 | 13.1 | 10.6 | 10.9 | | | |
| Changes in operating assets and liabilities, net of effects of acquisitions: | | | | | | | | |
| Accounts receivable | -142.3 | 5.7 | 38.8 | -161.3 | -81.4 | -34.2 | -79.2 | -13.7 |
| Inventory | -256.0 | -170.1 | -360.5 | -279.0 | -115.5 | -46.7 | -10.7 | -26.8 |
| Prepaids and other assets | -204.9 | -111.8 | -116.9 | -77.7 | -38.9 | -39.2 | -10.5 | -67.6 |
| Accounts payable | 36.0 | -32.3 | 12.3 | 16.7 | 14.0 | 15.9 | -11.3 | 17.7 |
| Accrued compensation and employee benefits | 115.1 | -16.6 | 57.4 | 26.2 | 31.2 | 18.7 | 21.5 | 21.4 |
| Deferred revenue | 32.6 | 15.0 | 35.5 | 54.3 | 43.7 | 14.1 | 8.2 | 19.8 |
| Other liabilities | 51.4 | 36.9 | 11.9 | 37.1 | 219.4 | 53.7 | | |
| Net cash provided by operating activities | 2,089.4 | 1,484.8 | 1,598.2 | 1,169.6 | 1,143.9 | 1,087.0 | 806.2 | 665.1 |
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| Investing activities: | | | | | | | | |
| Purchase of investments | -6,452.0 | -4,292.9 | -3,346.2 | -2,581.9 | -1,995.0 | -2,585.5 | -1,827.4 | -1,344.6 |
| Proceeds from sales of investments | 84.9 | 800.7 | 107.3 | 274.0 | 1,861.3 | 389.9 | 233.1 | 665.9 |
| Proceeds from maturities of investments | 4,267.8 | 2,930.8 | 2,569.8 | 1,533.6 | 703.1 | 970.1 | 825.8 | 714.7 |
| Purchase of property, plant, and equipment and intellectual property | -353.5 | -341.5 | -425.6 | -187.4 | -190.7 | -53.9 | -81.0 | -105.6 |
| Acquisition of businesses, net of cash, and other investing activities | 8.7 | 37.7 | 59.7 | 87.9 | | | | -84.3 |
| Net cash provided by (used in) investing activities | -2,461.5 | -940.6 | -1,154.4 | -1,049.6 | 378.7 | -1,279.4 | -849.5 | -153.9 |
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| Financing activities: | | | | | | | | |
| Proceeds from issuance of common stock relating to employee stock plans | 276.5 | 308.8 | 272.8 | 236.6 | 415.5 | 580.9 | 361.1 | 283.6 |
| Taxes paid related to net share settlement of equity awards | -211.6 | -175.2 | -159.1 | -120.0 | -56.6 | -24.0 | -11.0 | |
| Repurchase of common stock | | -134.3 | -269.5 | | -2,274.0 | -42.5 | -183.7 | -1,000.0 |
| Payment of deferred purchase consideration | -21.9 | -85.0 | -22.6 | | | | | |
| Net cash used in financing activities | 43.0 | -85.7 | -168.4 | 126.3 | -1,913.1 | 514.4 | 159.1 | -692.4 |
| Net increase (decrease) in cash, cash equivalents, and restricted cash | -332.5 | 455.9 | 273.2 | 246.2 | | | | |
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