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| In millions, except per share items | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| Baraclude | | | | | | | 1,312.0 | 1,441.0 |
| Erbitux | | | | | | | | 723.0 |
| Other | | | | | | | 15,248.0 | 13,715.0 |
| Total revenues [+] | 46,385.0 | 42,518.0 | 26,145.0 | 22,561.0 | 20,776.0 | 19,427.0 | 16,560.0 | 15,879.0 |
| Products | | | | | | | 14,045.0 | 11,660.0 |
| Other | | | | | | | 2,515.0 | 4,219.0 |
| Revenue growth [+] | 9.1% | 62.6% | 15.9% | 8.6% | 6.9% | 17.3% | 4.3% | -3.1% |
| Baraclude | | | | | | | -9.0% | -5.6% |
| Erbitux | | | | | | | | 3.9% |
| Sprycel | | | | | | | 8.5% | 16.6% |
| Cost of goods sold | 19,963.0 | 21,461.0 | 9,213.0 | 6,564.0 | 6,111.0 | 4,969.0 | 3,909.0 | 3,932.0 |
| Gross profit | 26,422.0 | 21,057.0 | 16,932.0 | 15,997.0 | 14,665.0 | 14,458.0 | 12,651.0 | 11,947.0 |
| Gross margin | 57.0% | 49.5% | 64.8% | 70.9% | 70.6% | 74.4% | 76.4% | 75.2% |
| Selling, general and administrative | 7,690.0 | 7,661.0 | 4,871.0 | 4,551.0 | 4,751.0 | 4,979.0 | 4,841.0 | 4,822.0 |
| Research and development | 11,354.0 | 11,143.0 | 6,148.0 | 6,332.0 | 6,468.0 | 5,012.0 | 5,920.0 | 4,534.0 |
| Equity in earnings | | | | | | | | |
| Other operating expenses | | 11,438.0 | | | -3,370.0 | -2,896.0 | -374.0 | 23.0 |
| EBITDA [+] | 18,064.0 | 1,195.0 | 7,659.0 | 5,751.0 | 7,605.0 | 7,745.0 | 2,640.0 | 3,035.0 |
| EBITDA growth | 1411.6% | -84.4% | 33.2% | -24.4% | -1.8% | 193.4% | -13.0% | -20.9% |
| EBITDA margin | 38.9% | 2.8% | 29.3% | 25.5% | 36.6% | 39.9% | 15.9% | 19.1% |
| Depreciation | 486.0 | 480.0 | 446.0 | 439.0 | 599.0 | 204.0 | 193.0 | 181.0 |
| EBITA | 17,578.0 | 715.0 | 7,213.0 | 5,312.0 | 7,006.0 | 7,541.0 | 2,447.0 | 2,854.0 |
| EBITA margin | 37.9% | 1.7% | 27.6% | 23.5% | 33.7% | 38.8% | 14.8% | 18.0% |
| Amortization of intangibles | 10,200.0 | 9,900.0 | 1,300.0 | 198.0 | 190.0 | 178.0 | 183.0 | 286.0 |
| EBIT [+] | 7,378.0 | -9,185.0 | 5,913.0 | 5,114.0 | 6,816.0 | 7,363.0 | 2,264.0 | 2,568.0 |
| EBIT growth | -180.3% | -255.3% | 15.6% | -25.0% | -7.4% | 225.2% | -11.8% | -16.5% |
| EBIT margin | 15.9% | -21.6% | 22.6% | 22.7% | 32.8% | 37.9% | 13.7% | 16.2% |
| Non-recurring items [+] | | | | | | | | -23.0 |
| Asset impairment | | | | | | | | 29.0 |
| Legal settlement | | | | | | | | -23.0 |
| Interest expense, net [+] | -39.0 | -121.0 | -464.0 | -173.0 | -126.0 | -97.0 | -101.0 | -101.0 |
| Interest expense | 1,334.0 | 1,420.0 | 656.0 | 183.0 | 196.0 | 167.0 | 184.0 | 203.0 |
| Interest income | 39.0 | 121.0 | 464.0 | 173.0 | 126.0 | 97.0 | 101.0 | 101.0 |
| Other income (expense), net [+] | 2,015.0 | 3,613.0 | -746.0 | 864.0 | -1,615.0 | -1,378.0 | -104.0 | -108.0 |
| Other | 720.0 | 2,314.0 | -938.0 | 854.0 | -1,685.0 | -1,448.0 | -187.0 | -210.0 |
| Pre-tax income | 8,098.0 | -6,871.0 | 4,975.0 | 5,968.0 | 5,131.0 | 5,915.0 | 2,077.0 | 2,381.0 |
| Income taxes | 1,084.0 | 2,124.0 | 1,515.0 | 1,021.0 | 4,156.0 | 1,408.0 | 446.0 | 352.0 |
| Tax rate | 13.4% | | 30.5% | 17.1% | 81.0% | 23.8% | 21.5% | 14.8% |
| Minority interest | 20.0 | 20.0 | 21.0 | 27.0 | -32.0 | 50.0 | 66.0 | 25.0 |
| Net income | 6,994.0 | -9,015.0 | 3,439.0 | 4,920.0 | 1,007.0 | 4,457.0 | 1,565.0 | 2,004.0 |
| Net margin | 15.1% | -21.2% | 13.2% | 21.8% | 4.8% | 22.9% | 9.5% | 12.6% |
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| Basic EPS [+] | $3.15 | ($3.99) | $2.02 | $3.01 | $0.61 | $2.67 | $0.94 | $1.21 |
| Growth | -178.9% | -297.9% | -33.1% | 392.2% | -77.0% | 184.1% | -22.4% | -22.4% |
| Diluted EPS [+] | $3.12 | ($3.99) | $2.01 | $3.01 | $0.61 | $2.65 | $0.93 | $1.20 |
| Growth | -178.0% | -298.8% | -33.2% | 393.1% | -77.0% | 184.6% | -22.3% | -22.2% |
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| Dividends per share [+] | $2.01 | $1.84 | $1.68 | $1.61 | $1.57 | $1.53 | $1.49 | $1.45 |
| Growth | 9.2% | 9.5% | 4.3% | 2.5% | 2.6% | 2.7% | 2.8% | 2.8% |
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| Shares outstanding (basic) [+] | 2,221.0 | 2,258.0 | 1,705.0 | 1,633.0 | 1,645.0 | 1,671.0 | 1,667.0 | 1,657.0 |
| Growth | -1.6% | 32.4% | 4.4% | -0.7% | -1.6% | 0.2% | 0.6% | 0.8% |
| Shares outstanding (diluted) [+] | 2,245.0 | 2,258.0 | 1,712.0 | 1,637.0 | 1,652.0 | 1,680.0 | 1,679.0 | 1,670.0 |
| Growth | -0.6% | 31.9% | 4.6% | -0.9% | -1.7% | 0.1% | 0.5% | 0.5% |
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| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |
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