In millions, except per share items | Dec-31-22 | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 |
| 10-K | 10-K | 10-K | 10-K | 10-K | S-1/A |
Statement of Cash Flows [Abstract] | | | | | | |
Cash flows from operating activities: | | | | | | |
Net loss | -59.0 | -95.5 | -45.0 | -43.3 | -23.8 | |
Adjustments to reconcile net loss to net cash used in operating activities: | | | | | | |
Depreciation and amortization | 1.0 | 1.0 | 1.1 | 0.8 | 0.5 | |
Discount accretion and premium amortization on marketable securities | 0.8 | 1.2 | 0.5 | -1.6 | | |
Equity‑based compensation | 29.0 | 21.2 | 11.1 | 3.5 | 1.0 | |
Change in operating assets and liabilities: | | | | | | |
Accounts receivable | 1.9 | 5.0 | -3.8 | -3.5 | | |
Prepaid expenses and other current assets | -5.5 | -4.0 | -0.8 | -1.9 | -0.7 | |
Other assets | -0.2 | 0.1 | 0.1 | -0.1 | -0.1 | |
Operating lease right-of-use assets | 1.3 | 1.1 | | | | |
Accounts payable | -1.6 | 1.0 | -1.1 | 3.2 | 0.9 | |
Accrued expenses | 0.1 | 1.5 | 3.5 | 3.4 | 1.9 | |
Deferred revenue | -67.6 | -14.8 | -11.5 | -2.2 | 96.6 | |
Net cash used in operating activities | -101.0 | -83.5 | -46.0 | -41.7 | 76.3 | |
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Cash flows from investing activities: | | | | | | |
Purchases of marketable securities | -238.3 | -244.2 | -145.3 | -296.3 | | |
Proceeds from maturities of marketable securities | 175.0 | 132.0 | 154.0 | 162.5 | | |
Purchases of property and equipment | -0.4 | -1.0 | -0.5 | -2.2 | -0.7 | |
Net cash used in investing activities | -56.5 | -113.2 | 8.2 | -136.0 | -0.7 | |
|
Cash flows from financing activities: | | | | | | |
Proceeds from issuance of common shares and pre-funded warrants through the private placement | | | | 93.3 | | |
Proceeds from issuance of common shares under Employee Stock Purchase Plan | 0.9 | 1.1 | 1.1 | | | |
Proceeds from issuance of common shares, net | | | | 93.3 | | |
Proceeds from issuance of common shares upon stock option exercises | 5.2 | 9.5 | 3.5 | 0.0 | | |
Net cash provided by financing activities | 45.3 | 266.3 | 38.3 | 93.3 | 89.5 | |
|
Non-cash activities: | | | | | | |
Purchases of property and equipment included in accounts payable and accrued expenses | 0.2 | | 0.0 | 0.3 | | |
Amounts from exercise of stock options included in prepaid expenses and other current assets | 0.0 | | | | | |