| In millions, except per share items | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 |
| | 8-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| Total revenues [+] | 28.9 | 5.0 | 9.5 | 9.7 | 5.3 | 6.5 | 3.8 | 2.4 |
| Royalties | | | | | | | | -9.4 |
| Products | 23.4 | | | | | | | |
| Grants | | | | | | | 3.8 | 2.4 |
| Revenue growth [+] | 474.8% | -47.0% | -1.8% | 81.5% | -17.9% | 72.1% | 57.1% | |
| Collaboration revenue - Upfront payment | | -80.4% | | | | | | |
| Cost of goods sold | 13.1 | -0.8 | -0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Gross profit | 15.7 | 5.8 | 9.6 | 9.7 | 5.3 | 6.5 | 3.8 | 2.4 |
| Gross margin | 54.5% | 115.2% | 100.7% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% |
| Selling, general and administrative [+] | 51.6 | 55.3 | 62.5 | 41.7 | 29.5 | 13.5 | 7.9 | 3.7 |
| General and administrative | | | | | | 13.5 | 7.9 | 3.7 |
| Research and development | 12.6 | 15.1 | 26.4 | 82.3 | 49.6 | 48.0 | 23.6 | 9.4 |
| Other operating expenses | | 1.5 | 0.1 | | | | | |
| EBITDA [+] | | -65.7 | -79.1 | -113.9 | -73.3 | -54.8 | -27.6 | -10.5 |
| EBITDA growth | -26.1% | -16.9% | -30.5% | 55.3% | 33.8% | 98.6% | 162.2% | |
| EBITDA margin | -167.9% | -1307.1% | -834.2% | -1179.2% | -1378.8% | -845.6% | -732.8% | -439.1% |
| Depreciation and amortization | | 0.4 | 0.4 | 0.5 | 0.4 | 0.2 | 0.2 | 0.2 |
| EBIT [+] | -48.5 | -66.1 | -79.5 | -114.4 | -73.8 | -55.0 | -27.8 | -10.7 |
| EBIT growth | -26.6% | -16.8% | -30.5% | 55.0% | 34.0% | 98.3% | 159.5% | |
| EBIT margin | -167.9% | -1315.4% | -838.4% | -1184.5% | -1386.9% | -849.2% | -736.9% | -446.0% |
| Interest expense, net [+] | 0.9 | 1.6 | 3.4 | 0.1 | -0.3 | -0.3 | 22.1 | 2.9 |
| Interest expense | 0.9 | 1.7 | 3.6 | 0.1 | 0.0 | 0.1 | 22.1 | 2.9 |
| Interest income | | 0.1 | 0.3 | 0.0 | 0.3 | 0.3 | 0.0 | 0.0 |
| Other income (expense), net [+] | 0.5 | -1.6 | 0.2 | -0.3 | 0.5 | -0.8 | 2.4 | -0.5 |
| Gain (loss) on debt retirement | | -2.8 | | | | | | |
| Other | | 1.2 | 0.2 | -0.3 | 0.5 | -0.8 | | -0.5 |
| Pre-tax income | -49.0 | -69.3 | -82.7 | -114.7 | -73.0 | -55.6 | -47.4 | -14.1 |
| Income taxes | 0.5 | 0.1 | 0.1 | 0.0 | 1.4 | -0.7 | -0.4 | 0.1 |
| Tax rate | | | | | | 1.2% | 0.9% | |
| Net income | -49.5 | -69.5 | -82.8 | -114.8 | -74.4 | -54.9 | -47.0 | -14.2 |
| Net margin | -171.1% | -1382.2% | -872.9% | -1188.7% | -1397.9% | -846.8% | -1246.7% | -593.1% |
| |
| Basic EPS [+] | ($1.14) | ($5.41) | ($11.15) | ($22.60) | ($2.49) | ($2.56) | ($4.44) | ($43.80) |
| Growth | -78.9% | -51.5% | -50.6% | 806.5% | -2.5% | -42.4% | -89.9% | |
| Diluted EPS [+] | ($1.14) | ($5.41) | ($11.15) | ($22.60) | ($2.49) | ($2.56) | ($4.44) | ($43.80) |
| Growth | -78.9% | -51.5% | -50.6% | 806.5% | -2.5% | -42.4% | -89.9% | |
| |
| Shares outstanding (basic) [+] | 43.3 | 12.8 | 7.4 | 5.1 | 29.8 | 21.5 | 10.6 | 0.3 |
| Growth | 237.5% | 73.1% | 46.1% | -83.0% | 38.9% | 102.9% | 3159.6% | |
| Shares outstanding (diluted) [+] | 43.3 | 12.8 | 7.4 | 5.1 | 29.8 | 21.5 | 10.6 | 0.3 |
| Growth | 237.5% | 73.1% | 46.1% | -83.0% | 38.9% | 102.9% | 3159.6% | |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |