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| In millions, except per share items | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-05-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 |
| | 10-K | 10-K | 10-K | 10-K | 8-K | 10-K | 10-K | 10-K |
| Revenues: |
| Revenue | | | | | | 1,852.8 | | |
| Clinical Solutions | 4,009.1 | 3,339.5 | 3,450.2 | 3,211.2 | | | | 906.5 |
| Commercial Solutions | 1,203.9 | 1,076.3 | 1,225.6 | 1,178.9 | | | | 8.2 |
| Other | | | | | | 819.2 | | 484.5 |
| Total revenues [+] | 5,213.0 | 4,415.8 | 4,675.8 | 4,390.1 | 4,390.1 | 2,672.1 | 1,610.6 | 1,399.2 |
| Services | | | | | | | | 914.7 |
| Reimbursements | | | | | | | | 484.5 |
| Revenue growth [+] | 18.1% | -5.6% | 6.5% | 64.3% | | 65.9% | 15.1% | 18.7% |
| Clinical Solutions | 20.1% | -3.2% | 7.4% | | | | | |
| Commercial Solutions | 11.9% | -12.2% | 4.0% | | | | | |
| Cost of goods sold [+] | 3,994.5 | 3,398.1 | 3,645.9 | 3,434.3 | 3,434.3 | 2,175.1 | 1,210.0 | 1,026.9 |
| Cost of services | | | | | | | | 542.4 |
| Reimbursable costs | | | | | | | | 484.5 |
| Gross profit | 1,218.5 | 1,017.6 | 1,029.9 | 955.8 | 955.8 | 497.0 | 400.6 | 372.3 |
| Gross margin | 23.4% | 23.0% | 22.0% | 21.8% | 21.8% | 18.6% | 24.9% | 26.6% |
| Selling, general and administrative | 570.8 | 472.7 | 507.6 | 406.3 | 406.3 | 282.6 | 172.4 | 156.6 |
| Other operating expenses | 0.2 | 0.2 | 17.3 | 53.3 | 64.8 | | 59.2 | 57.7 |
| EBITDA [+] | 647.6 | 544.7 | 505.1 | 496.3 | 484.7 | 214.4 | 228.2 | 214.1 |
| EBITDA growth | 18.9% | 7.8% | 1.8% | 131.5% | | -6.0% | 6.6% | 43.2% |
| EBITDA margin | 12.4% | 12.3% | 10.8% | 11.3% | 11.0% | 8.0% | 14.2% | 15.3% |
| Depreciation and amortization | 73.8 | 70.2 | 76.5 | 72.2 | 72.2 | 44.4 | 21.4 | 18.1 |
| EBITA | 573.7 | 474.5 | 428.6 | 424.1 | 412.5 | 170.0 | 206.8 | 196.0 |
| EBITA margin | 11.0% | 10.7% | 9.2% | 9.7% | 9.4% | 6.4% | 12.8% | 14.0% |
| Amortization of intangibles | 161.8 | 152.2 | 165.9 | 201.5 | 201.5 | 135.5 | 37.9 | 37.9 |
| EBIT [+] | 411.9 | 322.3 | 262.6 | 222.6 | 211.0 | 34.4 | 169.0 | 158.1 |
| EBIT growth | 27.8% | 22.7% | 18.0% | 546.1% | | -79.6% | 6.9% | 66.4% |
| EBIT margin | 7.9% | 7.3% | 5.6% | 5.1% | 4.8% | 1.3% | 10.5% | 11.3% |
| Non-recurring items [+] | 22.7 | 29.2 | 24.9 | 62.4 | 50.8 | 63.3 | 13.6 | 5.7 |
| Asset impairment | | | | | | 30.0 | | 3.9 |
| Interest expense, net [+] | 79.3 | 91.1 | 129.8 | 130.7 | 127.0 | 63.7 | 12.0 | 15.4 |
| Interest expense | 79.3 | 91.1 | 129.8 | 130.7 | 130.7 | 63.7 | 12.0 | 15.6 |
| Interest income | | | | | 3.7 | | | 0.2 |
| Other income (expense), net [+] | 5.1 | 1.7 | -6.2 | 27.8 | 24.1 | -19.3 | -9.2 | -5.9 |
| Gain (loss) on debt retirement | -3.6 | -1.6 | 10.4 | -4.2 | -4.2 | -0.6 | -0.4 | -9.8 |
| Other | 8.6 | 3.0 | -24.2 | 28.2 | -28.2 | -19.8 | -9.0 | 3.9 |
| Pre-tax income | 315.2 | 203.7 | 101.7 | 57.3 | 57.3 | -111.9 | 134.1 | 131.0 |
| Income taxes | 80.3 | 10.9 | -29.5 | 33.0 | 33.0 | 26.6 | 21.5 | 13.9 |
| Tax rate | 25.5% | 5.3% | | 57.6% | 57.6% | | 16.0% | 10.6% |
| Net income | 234.8 | 192.8 | 131.3 | 24.3 | 24.3 | -138.5 | 112.6 | 117.0 |
| Net margin | 4.5% | 4.4% | 2.8% | 0.6% | 0.6% | -5.2% | 7.0% | 8.4% |
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| Basic EPS [+] | $2.26 | $1.85 | $1.27 | $0.23 | $0.23 | ($1.85) | $2.08 | $2.02 |
| Growth | 22.2% | 46.1% | 439.4% | -112.7% | | -188.7% | 3.1% | -495.9% |
| Diluted EPS [+] | $2.24 | $1.83 | $1.25 | $0.23 | $0.23 | ($1.85) | $2.03 | $1.95 |
| Growth | 22.3% | 46.2% | 438.9% | -112.5% | | -191.3% | 4.1% | -481.1% |
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| Growth | | | | | | | | -100.0% |
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| Shares outstanding (basic) [+] | 103.9 | 104.2 | 103.6 | 103.4 | 103.4 | 74.9 | 54.0 | 57.9 |
| Growth | -0.3% | 0.5% | 0.2% | 38.0% | | 38.6% | -6.7% | 8.6% |
| Shares outstanding (diluted) [+] | 105.1 | 105.5 | 105.0 | 104.7 | 104.7 | 74.9 | 55.6 | 60.1 |
| Growth | -0.4% | 0.4% | 0.3% | 39.8% | | 34.7% | -7.5% | 12.8% |
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| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |
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