In millions, except per share items | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 |
| 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
Revenues [Abstract] | | | | | | | | |
Product sales, net | 194.7 | 123.8 | 2.1 | 9.0 | | | | |
Product sales, net growth | 57.3% | 5773.0% | -76.5% | | | | | |
Costs and operating expenses: | | | | | | | | |
Cost of sales | 3.3 | 2.0 | 0.0 | | | | | |
Research and development | 212.1 | 155.1 | 174.6 | 131.3 | 87.8 | 62.2 | 36.7 | 16.3 |
Selling, general and administrative | 267.0 | 210.9 | 117.1 | 51.4 | 31.4 | | | |
Total costs and operating expenses | 482.4 | 734.5 | 574.9 | 182.7 | 119.2 | | | |
Loss from operations | -287.7 | -243.2 | -281.3 | -182.7 | -119.2 | -83.1 | -46.4 | -20.5 |
Operating margin | -147.7% | -196.4% | -13343.6% | -2038.6% | | | | |
|
Other income (expense): | | | | | | | | |
Interest income | 0.7 | 5.8 | 15.6 | 9.0 | | | | |
Interest expense | -15.5 | -9.8 | -0.9 | -0.3 | | | | |
Other income (expense), net | -14.9 | -4.4 | 14.5 | 8.5 | 4.8 | 1.3 | 0.1 | 0.0 |
Total other income (expense,), net | -14.9 | -4.4 | 14.5 | 8.5 | -0.3 | | | |
Loss before income taxes | -302.6 | -247.6 | -266.8 | | | | | |
Provision for income taxes | 0.5 | | 0.0 | | | | | |
Net loss | -303.1 | -247.6 | -266.8 | -174.2 | -117.0 | -82.5 | -46.4 | -20.8 |
|
Other comprehensive loss: | | | | | | | | |
Cumulative translation adjustment | 0.3 | | | | | | | |
|
Total other comprehensive expense, net | | | | | | | | |
Comprehensive loss | -303.3 | -248.0 | -266.0 | -173.9 | -117.2 | -82.6 | -46.4 | -20.8 |
|
Basic net loss per common share | ($4.81) | ($4.04) | ($4.57) | ($3.41) | ($2.76) | ($2.48) | ($3.95) | ($14.20) |
Diluted net loss per common share | ($4.81) | ($4.04) | ($4.57) | ($3.41) | ($2.76) | ($2.48) | ($3.95) | ($14.20) |
|
Weighted-average number of shares used in computing basic net loss per common share | 63.0 | 61.3 | 58.3 | 51.2 | 42.4 | 33.2 | 12.8 | 1.7 |