| In millions, except per share items | Dec-31-10 | Dec-31-09 | Dec-31-08 | Dec-31-07 | Dec-31-06 | Dec-31-05 | Dec-31-04 | Dec-31-03 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Cash flows from operating activities: | | | | | | | | |
| Net loss | | | | -41.5 | -31.1 | -38.6 | -25.9 | -22.3 |
| Adjustments to reconcile net loss to net cash used in operating activities: | | | | | | | | |
| Depreciation and amortization | | | | 1.0 | 4.9 | 1.4 | 0.8 | 0.8 |
| Share-based compensation | | | | 2.0 | 2.6 | 0.5 | 0.5 | 0.2 |
| Changes in operating assets and liabilities: | | | | | | | | |
| Prepaid expenses and other assets | | | | 0.0 | | | | |
| Accounts receivable | | | | 0.3 | -0.3 | 0.3 | 0.0 | -0.3 |
| Accounts payable and other liabilities | | | | 0.9 | | | | |
| Accrued expenses | | | | -1.0 | 2.1 | 1.7 | 1.9 | -0.3 |
| Deferred revenue | | | | 0.1 | -0.2 | -0.1 | -0.2 | -0.2 |
| Net cash used in operating activities | | | | -8.2 | -23.8 | -35.0 | -21.5 | -21.6 |
| |
| Cash flows from investing activities: | | | | | | | | |
| Purchases of investments | -20.9 | -34.4 | -45.9 | -75.2 | -62.9 | -104.2 | -30.9 | -15.6 |
| Net cash (used in) provided by investing activities | | | | 4.0 | 11.6 | -42.6 | -15.9 | -0.7 |
| |
| Cash flows from financing activities: | | | | | | | | |
| Proceeds from the issuance of common stock | | | | 0.0 | 0.2 | 39.0 | 81.9 | 0.0 |
| Net cash provided by financing activities | | | | -1.3 | -2.0 | 39.8 | 82.3 | 20.3 |
| Increase (decrease) in cash and cash equivalents | | | | -5.5 | -14.2 | -37.7 | 44.9 | -2.0 |
| Cash and cash equivalents at beginning of period | | | | 19.7 | 33.8 | 71.6 | 26.6 | 28.7 |
| Cash and cash equivalents at end of period | | | | 14.2 | 19.7 | 33.8 | 71.6 | 26.6 |
| |
| Supplemental cash flow information: | | | | | | | | |
| Interest paid | | | | 0.1 | 0.3 | 0.2 | 0.2 | 0.2 |
| Non-cash financing activities: | | | | | | | | |