| In millions, except per share items | Dec-31-22 | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| Royalties | | | | | | | 7.8 | 8.0 |
| Total revenues [+] | 10.2 | 10.6 | 10.8 | 10.0 | 10.4 | 9.9 | 7.5 | 7.9 |
| Royalties | | | | | | | 7.8 | 8.0 |
| Revenue growth [+] | -4.6% | -1.7% | 8.3% | -4.1% | 5.4% | 31.5% | -4.5% | -20.0% |
| Royalties | | | | | | | -2.8% | 18.9% |
| Cost of goods sold | 0.3 | 0.5 | 0.5 | 0.5 | 0.6 | 0.5 | 0.7 | 0.6 |
| Gross profit | 9.9 | 10.1 | 10.3 | 9.5 | 9.9 | 9.4 | 6.8 | 7.3 |
| Gross margin | 97.5% | 95.0% | 95.1% | 95.0% | 94.6% | 94.9% | 90.9% | 92.9% |
| Selling, general and administrative [+] | 19.6 | 17.3 | 12.1 | 11.6 | 14.8 | 14.1 | 15.6 | 12.9 |
| General and administrative | 19.6 | 17.3 | 12.1 | 11.6 | 14.8 | 14.1 | 15.6 | 12.9 |
| Research and development | 43.3 | 34.9 | 23.1 | 22.3 | 24.4 | 45.1 | 31.3 | 26.5 |
| Equity in earnings | | | | | | | | |
| Other operating expenses | | | | | | 0.0 | | |
| EBITDA [+] | -52.8 | -41.9 | -24.8 | -24.2 | -29.2 | -49.5 | -39.9 | -32.0 |
| EBITDA growth | 26.0% | 69.3% | 2.2% | -16.9% | -41.1% | 24.3% | 24.7% | 103.6% |
| EBITDA margin | -519.5% | -393.5% | -228.5% | -242.2% | -279.6% | -500.4% | -529.5% | -405.8% |
| Depreciation and amortization | 0.2 | 0.2 | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | 0.2 |
| EBIT [+] | -53.0 | -42.1 | -24.9 | -24.4 | -29.3 | -49.8 | -40.1 | -32.1 |
| EBIT growth | 26.0% | 68.9% | 2.2% | -17.0% | -41.1% | 24.2% | 24.6% | 102.6% |
| EBIT margin | -521.7% | -395.0% | -229.8% | -243.5% | -281.3% | -502.7% | -532.1% | -407.9% |
| Non-recurring items [+] | | | | | | | 18.0 | 24.3 |
| In-process research & development | | | | | | | 18.0 | 24.3 |
| Interest expense, net [+] | -1.1 | -0.2 | -0.1 | 0.2 | 3.2 | 3.5 | 2.4 | 3.0 |
| Interest expense | | | | 0.8 | 3.9 | 4.0 | 2.8 | 3.3 |
| Interest income | 1.1 | 0.2 | 0.1 | 0.6 | 0.7 | 0.5 | 0.4 | 0.3 |
| Other income (expense), net [+] | -4.8 | -3.6 | -5.1 | -7.6 | | -0.1 | 0.0 | 0.5 |
| Gain (loss) on debt retirement | | | | -3.5 | | | | |
| Other | | 0.9 | 0.0 | -0.1 | | 0.1 | 0.0 | -0.5 |
| Pre-tax income | -56.7 | -45.4 | -29.9 | -32.1 | -32.6 | -53.3 | -60.4 | -59.0 |
| Income taxes | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Tax rate | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Net income | -56.7 | -45.4 | -29.9 | -32.1 | -32.6 | -53.3 | -60.4 | -59.0 |
| Net margin | -557.7% | -426.7% | -276.0% | -321.3% | -312.4% | -538.7% | -802.6% | -748.7% |
| |
| Basic EPS [+] | ($0.61) | ($0.50) | ($0.61) | ($0.97) | ($0.98) | ($1.79) | ($0.45) | ($0.48) |
| Growth | 22.3% | -19.3% | -36.6% | -1.5% | -45.0% | 292.9% | -4.8% | 119.5% |
| Diluted EPS [+] | ($0.61) | ($0.50) | ($0.61) | ($0.97) | ($0.98) | ($1.79) | ($0.45) | ($0.48) |
| Growth | 22.3% | -19.3% | -36.6% | -1.5% | -45.0% | 292.9% | -4.8% | 119.5% |
| |
| Shares outstanding (basic) [+] | 93.4 | 91.6 | 48.7 | 33.2 | 33.1 | 29.8 | 132.8 | 123.4 |
| Growth | 2.0% | 88.1% | 46.7% | 0.2% | 11.0% | -77.5% | 7.6% | 43.5% |
| Shares outstanding (diluted) [+] | 93.4 | 91.6 | 48.7 | 33.2 | 33.1 | 29.8 | 132.8 | 123.4 |
| Growth | 2.0% | 88.1% | 46.7% | 0.2% | 11.0% | -77.5% | 7.6% | 43.5% |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |