| In millions, except per share items | Dec-31-22 | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K/A |
| Revenues: |
| Thiola | | | | | | | | 54.9 |
| Other | | | | | | | | 45.0 |
| Revenues [+] | 212.0 | 227.5 | 198.3 | 175.3 | 164.2 | 154.9 | 138.1 | 99.9 |
| Products | | | | | 164.2 | 154.9 | | 99.9 |
| Revenue growth | -6.8% | 14.7% | 13.1% | 6.8% | 6.0% | 12.2% | 38.3% | 254.2% |
| Cost of goods sold | 7.6 | 6.8 | 6.1 | 5.2 | 5.5 | 3.6 | 4.6 | 2.2 |
| Gross profit | 204.4 | 220.7 | 192.2 | 170.1 | 158.7 | 151.3 | 133.6 | 97.7 |
| Gross margin | 96.4% | 97.0% | 96.9% | 97.0% | 96.6% | 97.7% | 96.7% | 97.8% |
| Selling, general and administrative | 220.2 | 149.9 | 135.8 | 129.0 | 103.7 | 101.3 | 91.9 | 79.5 |
| Research and development | 235.8 | 210.3 | 131.8 | 141.0 | 123.8 | 78.2 | 70.8 | 50.4 |
| Other operating expenses | | | | -3.0 | | | 4.6 | 140.0 |
| EBITDA [+] | -218.5 | -112.9 | -50.8 | -76.4 | -50.0 | -10.4 | -17.6 | -158.9 |
| EBITDA growth | 93.5% | 122.2% | -33.5% | 52.7% | 382.6% | -41.1% | -88.9% | 113.5% |
| EBITDA margin | -103.0% | -49.6% | -25.6% | -43.6% | -30.5% | -6.7% | -12.7% | -159.0% |
| Depreciation | 2.1 | 1.7 | 2.1 | 0.7 | 0.6 | 0.5 | 0.1 | 0.2 |
| EBITA | -220.6 | -114.6 | -52.9 | -77.1 | -50.7 | -10.8 | -17.7 | -159.0 |
| EBITA margin | -104.0% | -50.4% | -26.7% | -44.0% | -30.8% | -7.0% | -12.8% | -159.2% |
| Amortization of intangibles | 31.0 | 24.9 | 22.4 | 19.7 | 18.0 | 17.3 | 16.0 | 13.2 |
| EBIT [+] | -251.6 | -139.5 | -75.4 | -96.8 | -68.7 | -28.2 | -33.7 | -172.3 |
| EBIT growth | 80.3% | 85.1% | -22.1% | 40.9% | 143.9% | -16.5% | -80.4% | 115.8% |
| EBIT margin | -118.7% | -61.3% | -38.0% | -55.2% | -41.8% | -18.2% | -24.4% | -172.5% |
| Non-recurring items [+] | 15.0 | 22.3 | 100.8 | 40.6 | 11.3 | 25.6 | 24.5 | -121.5 |
| Asset impairment | | | | 25.5 | | | | 4.7 |
| Loss (gain) on sale of assets | | | | | | | | -140.0 |
| Unusual expense | 15.0 | 22.3 | 3.7 | 15.1 | 11.6 | 19.4 | | |
| Legal settlement | | | | | | 2.6 | 5.2 | |
| Loss on contingent liability | | | | | | | 18.4 | 13.8 |
| Interest expense, net [+] | -6.3 | -2.0 | -5.0 | -10.1 | 4.3 | 1.2 | 4.7 | 7.7 |
| Interest expense | 11.3 | 20.1 | 19.1 | 18.8 | 9.8 | 4.4 | 4.7 | 7.7 |
| Interest income | 6.3 | 2.0 | 5.0 | 10.1 | 5.5 | 3.2 | | |
| Other income (expense), net [+] | -6.6 | 0.2 | 1.5 | -0.3 | -17.5 | -3.4 | 5.4 | 164.0 |
| Gain (loss) on debt retirement | -7.6 | | | | -17.0 | | | -4.2 |
| Gain (loss) on foreign currency transactions | | | | | | | 0.1 | 0.0 |
| Change in fair value of warrants | | | | | | -4.5 | 1.7 | -33.3 |
| Other | 1.0 | 0.2 | 1.4 | -0.3 | -0.5 | 1.1 | -0.3 | -0.3 |
| Pre-tax income | -278.2 | -179.7 | -188.8 | -146.4 | -101.9 | -58.4 | -57.6 | 105.5 |
| Income taxes | 0.3 | 0.4 | -19.4 | 0.0 | 0.8 | 1.4 | -9.7 | -11.8 |
| Tax rate | | | 10.3% | 0.0% | | | 16.8% | |
| Net income | -278.5 | -180.1 | -169.4 | -146.4 | -102.7 | -59.7 | -47.9 | 117.2 |
| Net margin | -131.3% | -79.2% | -85.4% | -83.5% | -62.5% | -38.6% | -34.7% | 117.4% |
| |
| Basic EPS [+] | ($4.37) | ($3.01) | ($3.56) | ($3.46) | ($2.54) | ($1.54) | ($1.29) | $3.49 |
| Growth | 45.1% | -15.5% | 3.1% | 36.2% | 64.8% | 19.0% | -137.1% | -178.9% |
| Diluted EPS [+] | ($4.37) | ($3.01) | ($3.56) | ($3.46) | ($2.54) | ($1.54) | ($1.25) | $3.12 |
| Growth | 45.1% | -15.5% | 3.1% | 36.2% | 64.8% | 23.1% | -140.1% | -170.5% |
| |
| Shares outstanding (basic) [+] | 63.8 | 59.8 | 47.5 | 42.3 | 40.4 | 38.8 | 37.0 | 33.6 |
| Growth | 6.6% | 25.9% | 12.3% | 4.7% | 4.3% | 4.8% | 10.2% | 33.9% |
| Shares outstanding (diluted) [+] | 63.8 | 59.8 | 47.5 | 42.3 | 40.4 | 38.8 | 38.3 | 37.6 |
| Growth | 6.6% | 25.9% | 12.3% | 4.7% | 4.3% | 1.3% | 1.9% | 50.0% |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |