The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103   32,462 2,550,000 SH   DFND 1 2,550,000 0 0
ADICET BIO INC COM 007002108   5,364 600,000 SH   DFND 1 600,000 0 0
AEROVATE THERAPEUTICS INC COM 008064107   57,344 1,957,132 SH   DFND 1 1,957,132 0 0
ALTIMMUNE INC COM NEW 02155H200   42,770 2,600,000 SH   DFND 1 2,600,000 0 0
ALTIMMUNE INC COM NEW 02155H200   6,580 400,000 SH Call DFND 1 400,000 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105   6,898 612,079 SH   DFND 1 612,079 0 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102   5,304 2,336,389 SH   DFND 1 2,336,389 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   20,323 550,000 SH   DFND 1 550,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   81,540 1,576,872 SH   DFND 1 1,576,872 0 0
ARCELLX INC COMMON STOCK 03940C100   64,284 2,075,000 SH   DFND 1 2,075,000 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   9,620 650,000 SH   DFND 1 650,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   6,107 50,000 SH   DFND 1 50,000 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   24,569 1,650,000 SH   DFND 1 1,650,000 0 0
ATEA PHARMACEUTICALS INC COM 04683R106   7,442 1,547,181 SH   DFND 1 1,547,181 0 0
ATRECA INC CL A COM 04965G109   255 319,057 SH   DFND 1 319,057 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   745 392,167 SH   DFND 1 392,167 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   61,291 2,762,115 SH   DFND 1 2,762,115 0 0
AXONICS INC COM 05465P101   20,150 322,240 SH   DFND 1 322,240 0 0
AXSOME THERAPEUTICS INC COM 05464T104   25,067 325,000 SH   DFND 1 325,000 0 0
BIOATLA INC COM 09077B104   30,363 3,680,365 SH   DFND 1 3,680,365 0 0
BIOHAVEN LTD COM G1110E107   1,138 81,963 SH   DFND 1 81,963 0 0
BIOMEA FUSION INC COM 09077A106   26,730 3,170,872 SH   DFND 1 3,170,872 0 0
BRIDGEBIO PHARMA INC COM 10806X102   10,433 1,369,179 SH   DFND 1 1,369,179 0 0
CABALETTA BIO INC COM 12674W109   18,239 1,971,739 SH   DFND 1 1,971,739 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   1,741 561,600 SH   DFND 1 561,600 0 0
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104   922 288,169 SH   DFND 1 288,169 0 0
COGENT BIOSCIENCES INC COM 19240Q201   10,404 900,000 SH   DFND 1 900,000 0 0
CYTOKINETICS INC COM NEW 23282W605   13,563 296,000 SH   DFND 1 296,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103   52,839 5,150,000 SH   DFND 1 5,150,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   26,345 2,946,887 SH   DFND 1 2,946,887 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101   2,777 1,217,882 SH   DFND 1 1,217,882 0 0
ELEVATION ONCOLOGY INC COM 28623U101   1,854 1,952,032 SH   DFND 1 1,952,032 0 0
ERASCA INC COM 29479A108   46,605 10,813,246 SH   DFND 1 10,813,246 0 0
GALECTO INC COM 36322Q107   1,173 1,020,238 SH   DFND 1 1,020,238 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106   5,764 593,043 SH   DFND 1 593,043 0 0
GRAPHITE BIO INC COM 38870X104   662 199,547 SH   DFND 1 199,547 0 0
GREENLIGHT BIOSCIENCS HLDS P COMMON STOCK 39536G105   10,843 9,188,659 SH   DFND 1 9,188,659 0 0
HARPOON THERAPEUTICS INC COM 41358P106   392 540,600 SH   DFND 1 540,600 0 0
ICOSAVAX INC COM 45114M109   5,112 643,825 SH   DFND 1 643,825 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   6,360 350,000 SH   DFND 1 350,000 0 0
IMMUNEERING CORP CLASS A COM 45254E107   11,088 2,286,181 SH   DFND 1 2,286,181 0 0
IMMUNOVANT INC COM 45258J102   7,100 400,000 SH   DFND 1 400,000 0 0
KARUNA THERAPEUTICS INC COM 48576A100   21,615 110,000 SH   DFND 1 110,000 0 0
KEROS THERAPEUTICS INC COM 492327101   4,802 100,000 SH   DFND 1 100,000 0 0
LONGBOARD PHARMACEUTICALS IN COM 54300N103   6,906 2,118,283 SH   DFND 1 2,118,283 0 0
MIRATI THERAPEUTICS INC COM 60468T105   18,124 400,000 SH   DFND 1 400,000 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   22,021 2,893,717 SH   DFND 1 2,893,717 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   63,683 6,065,001 SH   DFND 1 6,065,001 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106   5,101 2,082,000 SH   DFND 1 2,082,000 0 0
ORCHARD THERAPEUTICS PLC SPON ADS 68570P101   95 256,649 SH   DFND 1 256,649 0 0
PHARVARIS N V COM N69605108   9,185 816,460 SH   DFND 1 816,460 0 0
PLIANT THERAPEUTICS INC COM 729139105   15,131 782,788 SH   DFND 1 782,788 0 0
POSEIDA THERAPEUTICS INC COM 73730P108   6,095 1,150,000 SH   DFND 1 1,150,000 0 0
PRIME MEDICINE INC COM 74168J101   13,644 734,350 SH   DFND 1 734,350 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   229,900 2,090,000 SH   DFND 1 2,090,000 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101   896 668,854 SH   DFND 1 668,854 0 0
RAIN ONCOLOGY INC COM 75082Q105   23,829 2,978,660 SH   DFND 1 2,978,660 0 0
REVOLUTION MEDICINES INC COM 76155X100   45,140 1,895,066 SH   DFND 1 1,895,066 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   16,998 868,550 SH   DFND 1 868,550 0 0
SAREPTA THERAPEUTICS INC COM 803607100   25,916 200,000 SH   DFND 1 200,000 0 0
STOKE THERAPEUTICS INC COM 86150R107   10,040 1,087,807 SH   DFND 1 1,087,807 0 0
TALARIS THERAPEUTICS INC COM 87410C104   919 900,649 SH   DFND 1 900,649 0 0
TANGO THERAPEUTICS INC COM 87583X109   29,848 4,116,949 SH   DFND 1 4,116,949 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   25,456 1,736,422 SH   DFND 1 1,736,422 0 0
VAXCYTE INC COM 92243G108   15,584 325,000 SH   DFND 1 325,000 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101   21,980 2,536,617 SH   DFND 1 2,536,617 0 0
VENTYX BIOSCIENCES INC COM 92332V107   35,434 1,080,643 SH   DFND 1 1,080,643 0 0
VERVE THERAPEUTICS INC COM 92539P101   6,773 350,000 SH   DFND 1 350,000 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   7,710 616,786 SH   DFND 1 616,786 0 0
VIKING THERAPEUTICS INC COM 92686J106   6,580 700,000 SH   DFND 1 700,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   32,131 1,100,000 SH   DFND 1 1,100,000 0 0
X4 PHARMACEUTICALS INC COM 98420X103   1,618 1,628,980 SH   DFND 1 1,628,980 0 0
Y-MABS THERAPEUTICS INC COM 984241109   732 150,000 SH   DFND 1 150,000 0 0