The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103   4,126,722 324,173 SH   SOLE   324,173 0 0
ACCURAY INC COM 004397105   2,554,728 1,222,358 SH   SOLE   1,222,358 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   180,265 15,648 SH   SOLE   15,648 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   512,553 351,064 SH   SOLE   351,064 0 0
ADICET BIO INC COM 007002108   5,646,093 631,554 SH   SOLE   631,554 0 0
AFFIMED N V COM N01045108   850,990 686,282 SH   SOLE   686,282 0 0
ALECTOR INC COM 014442107   4,914,403 532,438 SH   SOLE   532,438 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   4,314,993 83,446 SH   SOLE   83,446 0 0
ARCUS BIOSCIENCES INC COM 03969F109   2,941,048 142,217 SH   SOLE   142,217 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   15,902,792 130,212 SH   SOLE   130,212 0 0
ATRICURE INC COM 04963C209   3,196,647 72,029 SH   SOLE   72,029 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   2,234,685 1,176,150 SH   SOLE   1,176,150 0 0
AXOGEN INC COM 05463X106   3,314,388 332,103 SH   SOLE   332,103 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   3,617,120 122,200 SH   SOLE   122,200 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   2,881,480 251,000 SH   SOLE   251,000 0 0
BIOHAVEN LTD COM G1110E107   5,456,408 393,113 SH   SOLE   393,113 0 0
BIOMEA FUSION INC COM 09077A106   291,889 34,625 SH   SOLE   34,625 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   175,500 97,500 SH   SOLE   97,500 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   11,444,705 261,235 SH   SOLE   261,235 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106   543,400 220,000 SH   SOLE   220,000 0 0
CARDIOVASCULAR SYSTEMS COM 141619106   3,908,777 286,988 SH   SOLE   286,988 0 0
CENTURY THERAPEUTICS INC COM 15673T100   2,438,633 475,367 SH   SOLE   475,367 0 0
CINCOR PHARMA INC COM 17240Y109   589,920 48,000 SH   SOLE   48,000 0 0
COMPASS THERAPEUTICS INC COM 20454B104   3,028,316 602,051 SH   SOLE   602,051 0 0
COMPUGEN LTD ORD M25722105   146,863 205,202 SH   SOLE   205,202 0 0
CYMABAY THERAPEUTICS INC COM 23257D103   1,072,540 171,059 SH   SOLE   171,059 0 0
CYTOKINETICS INC COM NEW 23282W605   8,430,651 183,995 SH   SOLE   183,995 0 0
DEXCOM INC COM 252131107   7,649,588 67,552 SH   SOLE   67,552 0 0
DICE THERAPEUTICS INC COM 23345J104   3,853,200 123,500 SH   SOLE   123,500 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   6,855,576 766,843 SH   SOLE   766,843 0 0
FATE THERAPEUTICS INC COM 31189P102   5,558,985 550,940 SH   SOLE   550,940 0 0
F-STAR THERAPEUTICS INC COM 30315R107   3,645,888 576,881 SH   SOLE   576,881 0 0
GALAPAGOS NV SPON ADR 36315X101   2,337,717 52,675 SH   SOLE   52,675 0 0
GENFIT S A ADS 372279109   868,759 197,940 SH   SOLE   197,940 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   8,510,065 468,358 SH   SOLE   468,358 0 0
IKENA ONCOLOGY INC COM 45175G108   325,895 122,517 SH   SOLE   122,517 0 0
INOGEN INC COM 45780L104   295,650 15,000 SH   SOLE   15,000 0 0
ISHARES NASDAQ BIOTECH INDX ETF 464287556   13,457,225 102,500 SH   SOLE   102,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104   1,924,877 98,560 SH   SOLE   98,560 0 0
IVERIC BIO INC COM 46583P102   12,973,925 605,975 SH   SOLE   605,975 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   4,164,376 616,032 SH   SOLE   616,032 0 0
KARUNA THERAPEUTICS INC COM 48576A100   14,153,306 72,027 SH   SOLE   72,027 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   655,105 192,678 SH   SOLE   192,678 0 0
KEROS THERAPEUTICS INC COM 492327101   1,584,660 33,000 SH   SOLE   33,000 0 0
KINNATE BIOPHARMA INC COM 49705R105   433,149 71,008 SH   SOLE   71,008 0 0
KURA ONCOLOGY INC COM 50127T109   1,796,769 144,784 SH   SOLE   144,784 0 0
LARIMAR THERAPEUTICS INC COM 517125100   1,954,052 473,136 SH   SOLE   473,136 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109   163,800 140,000 SH   SOLE   140,000 0 0
MACROGENICS INC COM 556099109   267,588 39,879 SH   SOLE   39,879 0 0
MASIMO CORP COM 574795100   443,850 3,000 SH   SOLE   3,000 0 0
MEDICENNA THERAPEUTICS CORP COM 58490H107   302,280 660,000 SH   SOLE   660,000 0 0
MEDIWOUND LTD SHS NEW M68830112   2,753,066 204,082 SH   SOLE   204,082 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107   822,385 1,096,513 SH   SOLE   1,096,513 0 0
MERSANA THERAPEUTICS INC COM 59045L106   2,422,893 413,463 SH   SOLE   413,463 0 0
MERUS N V COM N5749R100   4,175,245 269,893 SH   SOLE   269,893 0 0
MIRATI THERAPEUTICS INC COM 60468T105   3,334,816 73,600 SH   SOLE   73,600 0 0
MORPHIC HOLDING INC COM 61775R105   5,228,742 195,467 SH   SOLE   195,467 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   8,733,572 73,121 SH   SOLE   73,121 0 0
NEURONETICS INC COM 64131A105   2,155,236 313,717 SH   SOLE   313,717 0 0
NEXTCURE INC COM 65343E108   264,651 187,696 SH   SOLE   187,696 0 0
NURIX THERAPEUTICS INC COM 67080M103   6,222,311 566,695 SH   SOLE   566,695 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   1,556,356 264,237 SH   SOLE   264,237 0 0
PARDES BIOSCIENCES INC COM 69945Q105   810,162 479,386 SH   SOLE   479,386 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109   9,688 321,856 SH   SOLE   321,856 0 0
REGULUS THERAPEUTICS INC COM 75915K309   761,110 555,555 SH   SOLE   555,555 0 0
REUNION NEUROSCIENCE INC COM 76134G103   42,911 47,679 SH   SOLE   47,679 0 0
REVOLUTION MEDICINES INC COM 76155X100   11,380,839 477,785 SH   SOLE   477,785 0 0
SAGE THERAPEUTICS INC COM 78667J108   6,876,871 180,306 SH   SOLE   180,306 0 0
SCYNEXIS INC COM NEW 811292200   239,100 153,269 SH   SOLE   153,269 0 0
SPDR S&P BIOTECH ETF ETF 78464A870   46,978,000 566,000 SH   SOLE   566,000 0 0
SPERO THERAPEUTICS INC COM 84833T103   216,250 125,000 SH   SOLE   125,000 0 0
STEREOTAXIS INC COM NEW 85916J409   28,318,747 13,680,554 SH   SOLE   13,680,554 0 0
SURFACE ONCOLOGY INC COM 86877M209   642,060 783,000 SH   SOLE   783,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   11,378,008 447,073 SH   SOLE   447,073 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206   954,502 265,878 SH   SOLE   265,878 0 0
THESEUS PHARMACEUTICALS INC COM 88369M101   407,658 81,859 SH   SOLE   81,859 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   2,110,575 168,846 SH   SOLE   168,846 0 0
VIKING THERAPEUTICS INC COM 92686J106   4,902,598 521,553 SH   SOLE   521,553 0 0
XENON PHARMACEUTICALS INC COM 98420N105   12,463,508 316,092 SH   SOLE   316,092 0 0