The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101   32,366 269,900 SH   DFND 1 269,900 0 0
ABBVIE INC COM 00287Y109   8,653 53,543 SH   DFND 1 53,543 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108   61 130,821 SH   DFND 1 130,821 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106   139 20,020 SH   DFND 1 20,020 0 0
ALPHABET INC CLASS A CL A 38259P508   1,092 12,380 SH   DFND 1 12,380 0 0
ALPHABET INC CLASS C CL C 38259P706   12,422 140,000 SH   DFND 1 0 0 140,000
ALPINE IMMUNE SCIENCES INC COM 02083G100   91 12,445 SH   DFND 1 12,445 0 0
ALTRIA GROUP INC COM 02209S103   20,219 442,340 SH   DFND 1 442,340 0 0
AMETEK INC COM 031100100   2,428 17,380 SH   DFND 1 17,380 0 0
AMGEN INC COM 031162100   9,510 36,210 SH   DFND 1 36,210 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300   793 85,585 SH   DFND 1 85,585 0 0
BANK OF AMERICA CORPORATION COM 060505104   1,406 42,440 SH   DFND 1 42,440 0 0
BANK OF NEW YORK MELLON CORP COM 064058100   24,140 530,320 SH   DFND 1 530,320 0 0
BECTON DICKINSON & CO COM 075887109   6,096 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108   367,001 783 SH   DFND 1 783 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702   2,369 7,670 SH   DFND 1 7,670 0 0
BHP GROUP LIMITED SPONSORED ADR 088606108   9,146 147,400 SH   DFND 1 147,400 0 0
BOEING CO COM 097023105   4,667 24,500 SH   DFND 1 24,500 0 0
BRISTOL-MYERS SQUIBB COMPANY COM 110122108   2,682 37,280 SH   DFND 1 37,280 0 0
BRITISH AMERICAN TOBACCO PLC SPONSORED ADR 110448107   946 23,650 SH   DFND 1 23,650 0 0
CIGNA CORPORATION COM 125509109   7,587 22,899 SH   DFND 1 22,899 0 0
COCA COLA CO COM 191216100   3,079 48,400 SH   DFND 1 48,400 0 0
CORVUS PHARMACEUTICALS INC COM 221015100   42 49,959 SH   DFND 1 49,959 0 0
DANAHER CORP COM 235851102   49,148 185,170 SH   DFND 1 185,170 0 0
ECOLAB INC COM 278865100   540 3,710 SH   DFND 1 3,710 0 0
EXXON MOBIL CORPORATION COM 30231G102   33,012 299,290 SH   DFND 1 299,290 0 0
FORTIVE CORP COM 34959J108   4,626 72,000 SH   DFND 1 72,000 0 0
GILEAD SCIENCES INC COM 375558103   1,599 18,630 SH   DFND 1 18,630 0 0
HONEYWELL INTERNATIONAL INC COM 438516106   3,472 16,200 SH   DFND 1 16,200 0 0
IDEX CORPORATION COM 45167R104   619 2,710 SH   DFND 1 2,710 0 0
INTUITIVE SURGICAL INC COM 46120E602   13,111 49,410 SH   DFND 1 49,410 0 0
JACK HENRY & ASSOCIATES INC COM 426281101   3,260 18,570 SH   DFND 1 18,570 0 0
JOHNSON & JOHNSON COM 478160104   59,962 339,440 SH   DFND 1 339,440 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103   51,236 157,080 SH   DFND 1 157,080 0 0
LOCKHEED MARTIN CORP COM 539830109   3,571 7,340 SH   DFND 1 7,340 0 0
MASTERCARD INC CL A 57636Q104   3,477 10,000 SH   DFND 1 10,000 0 0
MEDTRONIC INC COM 585055106   6,145 79,060 SH   DFND 1 79,060 0 0
MERCK & CO INC COM 58933Y105   2,520 22,710 SH   DFND 1 22,710 0 0
METLIFE INC COM 59156R108   766 10,580 SH   DFND 1 10,580 0 0
MOODYS CORPORATION COM 20775CZK3   14,683 52,700 SH   DFND 1 52,700 0 0
NASDAQ INC COM 631103108   6,166 100,500 SH   DFND 1 100,500 0 0
NESTLE SA SPONSORED ADR 641069406   27,351 237,130 SH   DFND 1 237,130 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205   15,821 116,900 SH   DFND 1 116,900 0 0
NUTRIEN LTD COM 67077M108   16,045 219,710 SH   DFND 1 219,710 0 0
OCULAR THERAPEUTIX INC COM 67576A100   48 17,000 SH   DFND 1 17,000 0 0
PARKER HANNIFIN CORPORATION COM 701094104   826 2,840 SH   DFND 1 2,840 0 0
PHILLIPS 66 COM 718546104   19,810 190,330 SH   DFND 1 190,330 0 0
PRUDENTIAL FINANCIAL INC COM 744320102   632 6,350 SH   DFND 1 6,350 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104   9,150 233,720 SH   DFND 1 233,720 0 0
ROPER TECHNOLOGIES INC COM 776696106   32,143 74,390 SH   DFND 1 74,390 0 0
SHELL PLC SPONSORED ADR 780259305   19,471 341,900 SH   DFND 1 341,900 0 0
STORE CAPITAL CORPORATION REIT 862121100   1,177 36,700 SH   DFND 1 36,700 0 0
UNION PACIFIC CORP COM 907818108   845 4,080 SH   DFND 1 4,080 0 0
US BANCORP COM 902973304   17,153 393,330 SH   DFND 1 393,330 0 0
VANGUARD FTSE EMERGING MARKETS ETF ETF 922042858   2,292 58,810 SH   DFND 1 58,810 0 0
VANGUARD HEALTH CARE ETF ETF 92204A504   2,168 8,740 SH   DFND 1 8,740 0 0
VANGUARD HIGH DIVIDEND YIELD ETF ETF 921946406   263 2,430 SH   DFND 1 2,430 0 0
VANGUARD S&P 500 ETF ETF 922908363   6,746 19,200 SH   DFND 1 19,200 0 0
VEEVA SYSTEMS INC-CLASS A CL A 922475108   323 2,000 SH   DFND 1 2,000 0 0
VERIZON COMMUNICATIONS INC COM 92343V104   307 7,800 SH   DFND 1 7,800 0 0
VISA INC CLASS A CL A 92826C839   31,929 153,680 SH   DFND 1 153,680 0 0
VONTIER CORP COM 928881101   1,361 70,406 SH   DFND 1 70,406 0 0
WABTEC CORPORATION COM 929740108   7,139 71,523 SH   DFND 1 71,523 0 0
WATERS CORPORATION COM 941848103   16,029 46,790 SH   DFND 1 46,790 0 0
WELLS FARGO & CO COM 949746101   14,841 359,440 SH   DFND 1 359,440 0 0
XTRACKERS HARVEST CSI 300 CHINA A-SHARES ETF ETF 233051879   328 11,700 SH   DFND 1 11,700 0 0