The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC NOTE 3.000% 6/1 68269GAB3 39,377 40,599,000 PRN   DFND 1 40,599,000 0 0
ACCOLADE INC NOTE 0.500% 4/0 00437EAB8 79,078 105,000,000 PRN   DFND 1 105,000,000 0 0
ACUTUS MED INC COM 005111109 2,333 2,651,667 SH   DFND 1 2,651,667 0 0
ADAPTHEALTH CORP COMMON STOCK 00653Q102 154,438 8,223,536 SH   DFND 1 8,223,536 0 0
ADC THERAPEUTICS SA SHS H0036K147 11,521 2,390,297 SH   DFND 1 2,390,297 0 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 170,826 174,372,000 PRN   DFND 1 174,372,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 73,456 4,855,005 SH   DFND 1 4,855,005 0 0
ALECTOR INC COM 014442107 9,982 1,055,192 SH   DFND 1 1,055,192 0 0
ALPHATEC HLDGS INC COM NEW 02081G201 22,137 2,532,792 SH   DFND 1 2,532,792 0 0
ALPHATEC HLDGS INC NOTE 0.750% 8/0 02081GAB8 81,430 100,000,000 PRN   DFND 1 100,000,000 0 0
AMEDISYS INC COM 023436108 34,822 359,765 SH   DFND 1 359,765 0 0
AN2 THERAPEUTICS INC COM 037326105 12,453 716,538 SH   DFND 1 716,538 0 0
ANAPTYSBIO INC COM 032724106 37,413 1,466,600 SH   DFND 1 1,466,600 0 0
ANNEXON INC COM 03589W102 3,609 583,913 SH   DFND 1 583,913 0 0
APELLIS PHARMACEUTICALS INC NOTE 3.500% 9/1 03753UAB2 99,115 51,885,000 PRN   DFND 1 51,885,000 0 0
APOLLO ENDOSURGERY INC COM 03767D108 9,643 1,750,000 SH   DFND 1 1,750,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 32,535 3,081,000 SH   DFND 1 3,081,000 0 0
BIOGEN INC COM 09062X103 88,110 330,000 SH   DFND 1 330,000 0 0
BROOKDALE SR LIVING INC COM 112463104 37,117 8,692,561 SH   DFND 1 8,692,561 0 0
BUTTERFLY NETWORK INC *W EXP 02/12/202 124155110 616 733,333 SH   DFND 1 733,333 0 0
CABALETTA BIO INC COM 12674W109 302 464,252 SH   DFND 1 464,252 0 0
CAREMAX INC COM CL A 14171W103 112,455 15,861,090 SH   DFND 1 15,861,090 0 0
CAREMAX INC *W EXP 06/08/202 14171W111 1,263 672,000 SH   DFND 1 672,000 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 62,816 4,896,000 SH   DFND 1 4,896,000 0 0
CENTENE CORP DEL COM 15135B101 36,104 464,000 SH   DFND 1 464,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 44,258 2,966,345 SH   DFND 1 2,966,345 0 0
CYTOKINETICS INC COM NEW 23282W605 39,395 813,112 SH   DFND 1 813,112 0 0
DA32 LIFE SCNCE TEC ACQSTN C CLASS A COM 23312M106 15,568 1,600,000 SH   DFND 1 1,600,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 20,671 1,032,000 SH   DFND 1 1,032,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 46,093 2,491,490 SH   DFND 1 2,491,490 0 0
DELCATH SYS INC COM NEW 24661P807 1,555 486,068 SH   DFND 1 486,068 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 38,702 3,933,137 SH   DFND 1 3,933,137 0 0
ENHABIT INC COM 29332G102 20,418 1,454,279 SH   DFND 1 1,454,279 0 0
EUCRATES BIOMEDICAL ACQU COR *W EXP 10/23/202 G3141W122 13 333,333 SH   DFND 1 333,333 0 0
EUCRATES BIOMEDICAL ACQU COR UNIT 10/23/2027 G3141W114 0 1 SH   DFND 1 1 0 0
EUCRATES BIOMEDICAL ACQUISIT SHS G3141W106 10,020 999,999 SH   DFND 1 999,999 0 0
EVOLUS INC COM 30052C107 43,390 5,390,103 SH   DFND 1 5,390,103 0 0
FOGHORN THERAPEUTICS INC COM 344174107 6,671 777,525 SH   DFND 1 777,525 0 0
GILEAD SCIENCES INC COM 375558103 94,851 1,537,539 SH   DFND 1 1,537,539 0 0
GLAUKOS CORP NOTE 2.750% 6/1 377322AB8 355,849 271,752,000 PRN   DFND 1 271,752,000 0 0
GLAUKOS CORP COM 377322102 0 0 SH   DFND 1 0 0 0
GRAYBUG VISION INC COMMON 38942Q103 4,967 5,281,713 SH   DFND 1 5,281,713 0 0
GUARDANT HEALTH INC NOTE 11/1 40131MAB5 65,033 89,036,000 PRN   DFND 1 89,036,000 0 0
HEALTH CATALYST INC NOTE 2.500% 4/1 42225TAB3 25,533 30,000,000 PRN   DFND 1 30,000,000 0 0
HILLEVAX INC COM 43157M102 45,344 2,653,231 SH   DFND 1 2,653,231 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 26,015 1,743,628 SH   DFND 1 1,743,628 0 0
IGNYTE ACQUISITION CORP *W EXP 01/05/202 45175H114 45 362,500 SH   DFND 1 362,500 0 0
IGNYTE ACQUISITION CORP COM 45175H106 7,236 725,000 SH   DFND 1 725,000 0 0
IMMUNOGEN INC COM 45253H101 65,678 13,740,205 SH   DFND 1 13,740,205 0 0
INOZYME PHARMA INC COM 45790W108 5,602 2,090,436 SH   DFND 1 2,090,436 0 0
INSMED INC NOTE 1.750% 1/1 457669AA7 73,212 75,000,000 PRN   DFND 1 75,000,000 0 0
INSMED INC COM PAR $.01 457669307 20,689 960,484 SH   DFND 1 960,484 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.500% 2/1 45845PAC2 81,098 78,500,000 PRN   DFND 1 78,500,000 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 56,098 57,791,000 PRN   DFND 1 57,791,000 0 0
INVITAE CORP NOTE 2.000% 9/0 46185LAB9 162,218 206,873,000 PRN   DFND 1 206,873,000 0 0
IONIS PHARMACEUTICALS INC NOTE 4/0 462222AD2 128,518 127,800,000 PRN   DFND 1 127,800,000 0 0
IVERIC BIO INC COM 46583P102 76,139 4,244,098 SH   DFND 1 4,244,098 0 0
IVERIC BIO INC COM 46583P102 8,073 450,000 SH Call DFND 1 450,000 0 0
IVERIC BIO INC COM 46583P102 9,867 550,000 SH Call DFND 1 550,000 0 0
KINNATE BIOPHARMA INC COM 49705R105 2,988 250,000 SH   DFND 1 250,000 0 0
KRYSTAL BIOTECH INC COM 501147102 12,198 175,000 SH   DFND 1 175,000 0 0
KURA ONCOLOGY INC COM 50127T109 30,313 2,219,128 SH   DFND 1 2,219,128 0 0
LARIMAR THERAPEUTICS INC COM 517125100 54,212 16,941,357 SH   DFND 1 16,941,357 0 0
MEDAVAIL HOLDINGS INC COM 58406B103 649 836,626 SH   DFND 1 836,626 0 0
MEDTECH ACQUISITION CORP UNIT 12/18/2025 58507N204 0 1 SH   DFND 1 1 0 0
MEDTECH ACQUISITION CORP COM CL A 58507N105 9,930 999,999 SH   DFND 1 999,999 0 0
MEDTECH ACQUISITION CORP *W EXP 12/22/202 58507N113 20 333,333 SH   DFND 1 333,333 0 0
MERUS N V COM N5749R100 50,507 2,521,553 SH   DFND 1 2,521,553 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 42,699 2,032,335 SH   DFND 1 2,032,335 0 0
MOLINA HEALTHCARE INC COM 60855R100 24,738 75,000 SH   DFND 1 75,000 0 0
NANOSTRING TECHNOLOGIES INC NOTE 2.625% 3/0 63009RAD1 48,669 57,604,000 PRN   DFND 1 57,604,000 0 0
NATERA INC NOTE 2.250% 5/0 632307AB0 51,398 37,638,000 PRN   DFND 1 37,638,000 0 0
NEOGENOMICS INC NOTE 1.250% 5/0 64049MAA8 5,571 6,500,000 PRN   DFND 1 6,500,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 160,665 1,512,714 SH   DFND 1 1,512,714 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 39,609 42,000,000 PRN   DFND 1 42,000,000 0 0
NOVAVAX INC NOTE 3.750% 2/0 670002AB0 24,388 25,000,000 PRN   DFND 1 25,000,000 0 0
NUVALENT INC COM 670703107 375,990 19,341,024 SH   DFND 1 19,341,024 0 0
NUVASIVE INC NOTE 1.000% 6/0 670704AL9 93,716 96,966,000 PRN   DFND 1 96,966,000 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119 33 166,666 SH   DFND 1 166,666 0 0
NUVATION BIO INC COM CL A 67080N101 550 245,360 SH   DFND 1 245,360 0 0
NYXOAH S A SHS B6S7WD106 2,868 455,262 SH   DFND 1 455,262 0 0
OAK STR HEALTH INC NOTE 3/1 67181AAB3 52,497 68,000,000 SH   DFND 1 68,000,000 0 0
ONCORUS INC COM 68236R103 2,677 3,148,977 SH   DFND 1 3,148,977 0 0
ORCHARD THERAPEUTICS PLC SPON ADS 68570P101 3,475 6,949,416 SH   DFND 1 6,949,416 0 0
ORION ACQUISITION CORP *W EXP 02/19/202 68626A116 7 125,000 SH   DFND 1 125,000 0 0
ORION ACQUISITION CORP COM CL A 68626A108 4,923 500,000 SH   DFND 1 500,000 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 11,732 2,021,000 SH   DFND 1 2,021,000 0 0
PACIRA BIOSCIENCES INC COM 695127100 15,531 292,000 SH   DFND 1 292,000 0 0
PACIRA BIOSCIENCES INC NOTE 0.750% 8/0 695127AF7 80,771 81,600,000 PRN   DFND 1 81,600,000 0 0
PEPGEN INC COM 713317105 6,767 745,293 SH   DFND 1 745,293 0 0
PHARVARIS N V COM N69605108 8,472 1,104,552 SH   DFND 1 1,104,552 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 26,757 2,414,897 SH   DFND 1 2,414,897 0 0
PHREESIA INC COM 71944F106 34,602 1,358,000 SH   DFND 1 1,358,000 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 7,730 1,000,000 SH   DFND 1 1,000,000 0 0
PROFOUND MED CORP COM NEW 74319B502 2,959 732,543 SH   DFND 1 732,543 0 0
PTC THERAPEUTICS INC NOTE 1.500% 9/1 69366JAD3 37,558 32,000,000 PRN   DFND 1 32,000,000 0 0
PULMONX CORP COM 745848101 61,990 3,720,901 SH   DFND 1 3,720,901 0 0
QUANTUM SI INC COM CL A 74765K105 3,850 1,400,000 SH   DFND 1 1,400,000 0 0
QUANTUM SI INC *W EXP 06/10/202 74765K113 177 333,333 SH   DFND 1 333,333 0 0
REVOLUTION HEALTHCAR AQ CORP CLASS A COM 76155Y108 9,820 1,000,000 SH   DFND 1 1,000,000 0 0
REVOLUTION HEALTHCAR AQ CORP *W EXP 12/31/202 76155Y116 9 200,000 SH   DFND 1 200,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 57,022 2,891,587 SH   DFND 1 2,891,587 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 13,885 870,000 SH   DFND 1 870,000 0 0
ROIVANT SCIENCES LTD *W EXP 09/30/202 G76279119 390 1,000,000 SH   DFND 1 1,000,000 0 0
SAREPTA THERAPEUTICS INC DBCV 1.500%11/1 803607AB6 148,264 88,657,000 PRN   DFND 1 88,657,000 0 0
SARISSA CAPITAL ACQUISITN CO UNIT 10/23/2027 G7823W128 0 1 SH   DFND 1 1 0 0
SARISSA CAPITAL ACQUISITN CO CL A G7823W102 10,000 999,999 SH   DFND 1 999,999 0 0
SARISSA CAPITAL ACQUISITN CO *W EXP 10/23/202 G7823W110 7 333,333 SH   DFND 1 333,333 0 0
SEMA4 HOLDINGS CORP COM CL A 81663L101 14,894 16,973,488 SH   DFND 1 16,973,488 0 0
SENIOR CONNECT ACQUISITN COR *W EXP 12/31/202 81723H116 10 500,000 SH   DFND 1 500,000 0 0
SENIOR CONNECT ACQUISITN COR COM CL A 81723H108 9,945 1,000,000 SH   DFND 1 1,000,000 0 0
SILK RD MED INC COM 82710M100 114,092 2,535,369 SH   DFND 1 2,535,369 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 17,695 7,078,019 SH   DFND 1 7,078,019 0 0
SOMALOGIC INC *W EXP 08/31/202 83444K113 53 120,000 SH   DFND 1 120,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 23,309 816,994 SH   DFND 1 816,994 0 0
SURROZEN INC *W EXP 08/01/203 86889P117 31 166,666 SH   DFND 1 166,666 0 0
TABULA RASA HEALTHCARE INC NOTE 1.750% 2/1 873379AA9 115,533 144,516,000 PRN   DFND 1 144,516,000 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 22,671 1,324,214 SH   DFND 1 1,324,214 0 0
LIVONGO HEALTH INC NOTE 0.875% 6/0 539183AA1 41,977 50,000,000 PRN   DFND 1 50,000,000 0 0
TERNS PHARMACEUTICALS INC COM 880881107 10,955 1,860,000 SH   DFND 1 1,860,000 0 0
TG THERAPEUTICS INC COM 88322Q108 15,851 2,677,500 SH   DFND 1 2,677,500 0 0
THE ONCOLOGY INSTITUTE INC *W EXP 11/15/202 68236X118 691 1,250,000 SH   DFND 1 1,250,000 0 0
THE ONCOLOGY INSTITUTE INC COM 68236X100 15,557 3,360,052 SH   DFND 1 3,360,052 0 0
TURMERIC ACQUISITION CORP *W EXP 10/08/202 G9127T124 7 250,000 SH   DFND 1 250,000 0 0
TURMERIC ACQUISITION CORP CL A G9127T108 7,500 750,000 SH   DFND 1 750,000 0 0
VERICEL CORP COM 92346J108 11,251 484,947 SH   DFND 1 484,947 0 0
VERVE THERAPEUTICS INC COM 92539P101 25,763 750,000 SH   DFND 1 750,000 0 0
VIATRIS INC COM 92556V106 90,940 10,673,700 SH   DFND 1 10,673,700 0 0
VIGIL NEUROSCIENCE INC COM 92673K108 17,951 2,054,794 SH   DFND 1 2,054,794 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 4,321 958,125 SH   DFND 1 958,125 0 0
WINDTREE THERAPEUTICS INC COM 97382D303 6 20,148 SH   DFND 1 20,148 0 0
XERIS BIOPHARMA HOLDINGS INC NOTE 5.000% 7/1 98422LAA5 17,384 18,000,000 PRN   DFND 1 18,000,000 0 0