The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
5 01 ACQUISITION CORP COM CL A 33836P105 7,500 750,000 SH   SOLE   750,000 0 0
89BIO INC COM 282559103 45,062 7,782,669 SH   SOLE   7,782,669 0 0
AADI BIOSCIENCE INC COM 00032Q104 8,340 590,218 SH   SOLE   590,218 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 11,333 5,014,687 SH   SOLE   5,014,687 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 69,231 4,398,453 SH   SOLE   4,398,453 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 98,001 9,770,773 SH   SOLE   9,770,773 0 0
ADICET BIO INC COM 007002108 29,284 2,059,372 SH   SOLE   2,059,372 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 5 10,439 SH   SOLE   10,439 0 0
AEROVATE THERAPEUTICS INC COM 008064107 137,017 8,263,982 SH   SOLE   8,263,982 0 0
AKERO THERAPEUTICS INC COM 00973Y108 32,653 958,980 SH   SOLE   958,980 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 31,368 4,356,632 SH   SOLE   4,356,632 0 0
AN2 THERAPEUTICS INC COM 037326105 65,584 3,773,517 SH   SOLE   3,773,517 0 0
APTINYX INC COM 03836N103 720 1,954,698 SH   SOLE   1,954,698 0 0
ARYA SCIENCES ACQUISITN CORP CLASS A ORD SHS G31658100 9,800 1,000,000 SH   SOLE   1,000,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 781,462 7,567,900 SH   SOLE   7,567,900 0 0
ATHIRA PHARMA INC COM 04746L104 5,578 1,878,000 SH   SOLE   1,878,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 35,393 2,167,391 SH   SOLE   2,167,391 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 12,525 1,250,000 SH   SOLE   1,250,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 120,232 11,385,574 SH   SOLE   11,385,574 0 0
BIOGEN INC COM 09062X103 250,325 937,549 SH   SOLE   937,549 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 4,377 2,589,904 SH   SOLE   2,589,904 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 789 533,432 SH   SOLE   533,432 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 58,328 2,075,000 SH   SOLE   2,075,000 0 0
COGENT COMMUNICATIONS HLDGS COM NEW 19240Q201 59,881 4,013,453 SH   SOLE   4,013,453 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 7,292 1,088,296 SH   SOLE   1,088,296 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 9,018 6,991,003 SH   SOLE   6,991,003 0 0
CVRX INC COM 126638105 2,566 275,000 SH   SOLE   275,000 0 0
CYTEK BIOSCIENCES INC COM 23285D109 196,969 13,381,054 SH   SOLE   13,381,054 0 0
DA32 LIFE SCNCE CLASS A COM 23312M106 14,595 1,500,000 SH   SOLE   1,500,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 141,024 7,040,622 SH   SOLE   7,040,622 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 6,593 3,724,740 SH   SOLE   3,724,740 0 0
DESIGN THERAPEUTICS INC COM 25056L103 46,368 2,773,231 SH   SOLE   2,773,231 0 0
DICE THERAPEUTICS INC COM 23345J104 105,637 5,208,911 SH   SOLE   5,208,911 0 0
ELIEM THERAPEUTICS INC COM 28658R106 42,477 13,150,849 SH   SOLE   13,150,849 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 46,513 896,724 SH   SOLE   896,724 0 0
ENTERA BIO LTD SHS M40527109 2,166 2,082,372 SH   SOLE   2,082,372 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 26,660 3,370,506 SH   SOLE   3,370,506 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 179,782 9,011,651 SH   SOLE   9,011,651 0 0
FRAZIER LIFESCIENCES ACQU CO CL A SHS G3710A121 9,980 1,000,000 SH   SOLE   1,000,000 0 0
FULCRUM THERAPEUTICS INC COM 359616109 56,630 7,000,000 SH   SOLE   7,000,000 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 1,987 659,992 SH   SOLE   659,992 0 0
GERON CORP COM 374163103 70,496 30,126,299 SH   SOLE   30,126,299 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 56,919 4,898,373 SH   SOLE   4,898,373 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 6,042 610,283 SH   SOLE   610,283 0 0
HILLEVAX INC COM 43157M102 30,079 1,760,019 SH   SOLE   1,760,019 0 0
ICOSAVAX INC COM 45114M109 18,845 5,963,565 SH   SOLE   5,963,565 0 0
IMMUNOGEN INC COM 45253H101 103,924 21,741,458 SH   SOLE   21,741,458 0 0
INSTIL BIO INC COM 45783C101 37,127 7,670,793 SH   SOLE   7,670,793 0 0
IO BIOTECH INC COM 449778109 5,035 1,857,755 SH   SOLE   1,857,755 0 0
ITEOS THERAPEUTICS INC COM 46565G104 84,149 4,417,259 SH   SOLE   4,417,259 0 0
JANUX THERAPEUTICS INC COM 47103J105 117,401 8,670,644 SH   SOLE   8,670,644 0 0
KINNATE BIOPHARMA INC COM 49705R105 50,956 4,264,144 SH   SOLE   4,264,144 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 95,415 2,338,610 SH   SOLE   2,338,610 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 5,059 3,588,081 SH   SOLE   3,588,081 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 20,645 2,246,503 SH   SOLE   2,246,503 0 0
NANOSTRING TECHNOLOGIES COM 63009R109 58,774 4,602,478 SH   SOLE   4,602,478 0 0
NKARTA INC COM 65487U108 102,716 7,805,129 SH   SOLE   7,805,129 0 0
PARDES BIOSCIENCES INC COM 69945Q105 11,424 6,175,038 SH   SOLE   6,175,038 0 0
PEPGEN INC COM 713317105 73,838 8,131,952 SH   SOLE   8,131,952 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 20,352 1,710,265 SH   SOLE   1,710,265 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 1,506 764,653 SH   SOLE   764,653 0 0
RELAY THERAPEUTICS INC COM 75943R102 16,053 717,618 SH   SOLE   717,618 0 0
RELMADA THERAPEUTICS INC COM 75955J402 74,040 2,000,000 SH   SOLE   2,000,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 134,041 5,471,067 SH   SOLE   5,471,067 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 33,630 2,107,149 SH   SOLE   2,107,149 0 0
RXSIGHT INC COM 78349D107 36,633 3,052,796 SH   SOLE   3,052,796 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 35,486 5,914,252 SH   SOLE   5,914,252 0 0
SENSEI BIOTHERAPEUTICS COM 81728A108 1,059 683,529 SH   SOLE   683,529 0 0
SOLID BIOSCIENCES INC COM 83422E105 5,771 12,367,873 SH   SOLE   12,367,873 0 0
SYNLOGIC INC COM 87166L100 4,387 4,618,415 SH   SOLE   4,618,415 0 0
TENAYA THERAPEUTICS INC COM 87990A106 4,646 1,602,009 SH   SOLE   1,602,009 0 0
THIRD HARMONIC BIO INC COM 88427A107 65,934 3,475,687 SH   SOLE   3,475,687 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 121,301 4,922,941 SH   SOLE   4,922,941 0 0
TYRA BIOSCIENCES INC COM 90240B106 63,609 7,236,454 SH   SOLE   7,236,454 0 0
VAXCYTE INC COM 92243G108 109,949 4,581,203 SH   SOLE   4,581,203 0 0
VERA THERAPEUTICS INC CL A 92337R101 33,645 1,578,820 SH   SOLE   1,578,820 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 61,831 6,050,000 SH   SOLE   6,050,000 0 0
VIRIDIAN THERAPEUTICS INC SPONSORED ADS 92790C104 18,049 880,000 SH   SOLE   880,000 0 0
VOR BIOPHARMA INC COM 929033108 44,261 11,120,973 SH   SOLE   11,120,973 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 62,099 17,202,009 SH   SOLE   17,202,009 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 19,356 4,291,881 SH   SOLE   4,291,881 0 0