The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 34,651 267,760 SH   DFND 1 267,760 0 0
ABBVIE INC COM 00287Y109 8,201 53,543 SH   DFND 1 53,543 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 131 130,821 SH   DFND 1 130,821 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 80 20,020 SH   DFND 1 20,020 0 0
ALPHABET INC CLASS A SPONSORED ADR 38259P508 756 347 SH   DFND 1 347 0 0
ALPHABET INC CLASS C CL C 38259P706 15,312 7,000 SH   DFND 1 0 0 7,000
ALPINE IMMUNE SCIENCES INC COM 02083G100 106 12,445 SH   DFND 1 12,445 0 0
ALTRIA GROUP INC COM 02209S103 18,701 447,710 SH   DFND 1 447,710 0 0
AMETEK INC COM 031100100 1,864 16,960 SH   DFND 1 16,960 0 0
AMGEN INC COM 031162100 8,810 36,210 SH   DFND 1 36,210 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 857 85,585 SH   DFND 1 85,585 0 0
BANK OF AMERICA CORPORATION COM 060505104 1,321 42,440 SH   DFND 1 42,440 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 22,120 530,320 SH   DFND 1 530,320 0 0
BECTON DICKINSON & CO COM 075887109 5,909 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 320,208 783 SH   DFND 1 783 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 2,094 7,670 SH   DFND 1 7,670 0 0
BHP GROUP LIMITED SPONSORED ADR 088606108 8,281 147,400 SH   DFND 1 147,400 0 0
BOEING CO SPONSORED ADR 097023105 3,350 24,500 SH   DFND 1 24,500 0 0
BRISTOL-MYERS SQUIBB COMPANY COM 110122108 2,871 37,280 SH   DFND 1 37,280 0 0
BRITISH AMERICAN TOBACCO PLC SPONSORED ADR 110448107 1,015 23,650 SH   DFND 1 23,650 0 0
CIGNA CORPORATION COM 125509109 6,034 22,899 SH   DFND 1 22,899 0 0
COCA COLA CO COM 191216100 3,045 48,400 SH   DFND 1 48,400 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 49 49,959 SH   DFND 1 49,959 0 0
DANAHER CORP COM 235851102 46,944 185,170 SH   DFND 1 185,170 0 0
ECOLAB INC COM 278865100 570 3,710 SH   DFND 1 3,710 0 0
EXXON MOBIL CORPORATION COM 30231G102 25,631 299,290 SH   DFND 1 299,290 0 0
FIDELITY NATIONAL INFORMATION SERVICES INC COM 31620M106 259 2,820 SH   DFND 1 2,820 0 0
FORTIVE CORP COM 34959J108 3,915 72,000 SH   DFND 1 72,000 0 0
GILEAD SCIENCES INC COM 375558103 1,152 18,630 SH   DFND 1 18,630 0 0
HONEYWELL INTERNATIONAL INC COM 438516106 2,816 16,200 SH   DFND 1 16,200 0 0
IDEX CORPORATION COM 45167R104 492 2,710 SH   DFND 1 2,710 0 0
INTUITIVE SURGICAL INC COM 46120E602 9,917 49,410 SH   DFND 1 49,410 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 3,343 18,570 SH   DFND 1 18,570 0 0
JOHNSON & JOHNSON COM 478160104 60,254 339,440 SH   DFND 1 339,440 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 45,050 156,680 SH   DFND 1 156,680 0 0
LOCKHEED MARTIN CORP COM 539830109 3,156 7,340 SH   DFND 1 7,340 0 0
MASTERCARD INC CL A 57636Q104 3,155 10,000 SH   DFND 1 10,000 0 0
MEDTRONIC INC COM 585055106 7,096 79,060 SH   DFND 1 79,060 0 0
MERCK & CO INC COM 58933Y105 2,198 24,110 SH   DFND 1 24,110 0 0
METLIFE INC COM 59156R108 664 10,580 SH   DFND 1 10,580 0 0
MOODYS CORPORATION COM 20775CZK3 14,257 52,420 SH   DFND 1 52,420 0 0
NASDAQ INC COM 631103108 5,110 33,500 SH   DFND 1 33,500 0 0
NESTLE SA SPONSORED ADR 641069406 27,600 237,130 SH   DFND 1 237,130 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 13,026 116,900 SH   DFND 1 116,900 0 0
NUTRIEN LTD COM 67077M108 17,509 219,710 SH   DFND 1 219,710 0 0
OCULAR THERAPEUTIX INC COM 67576A100 68 17,000 SH   DFND 1 17,000 0 0
PARKER HANNIFIN CORPORATION COM 701094104 699 2,840 SH   DFND 1 2,840 0 0
PHILLIPS 66 COM 718546104 15,605 190,330 SH   DFND 1 190,330 0 0
PRUDENTIAL FINANCIAL INC COM 744320102 608 6,350 SH   DFND 1 6,350 0 0
ROCHE HOLDING AG COM 771195104 9,602 230,220 SH   DFND 1 230,220 0 0
ROPER TECHNOLOGIES INC COM 776696106 29,358 74,390 SH   DFND 1 74,390 0 0
SHELL PLC SPONSORED ADR 780259305 17,878 341,900 SH   DFND 1 341,900 0 0
STORE CAPITAL CORPORATION SPONSORED ADR 862121100 957 36,700 SH   DFND 1 36,700 0 0
UNION PACIFIC CORP COM 907818108 870 4,080 SH   DFND 1 4,080 0 0
US BANCORP COM 902973304 18,101 393,330 SH   DFND 1 393,330 0 0
VANGUARD FTSE EMERGING MARKETS ETF COM 922042858 2,449 58,810 SH   DFND 1 58,810 0 0
VANGUARD HEALTH CARE ETF ETF 92204A504 2,058 8,740 SH   DFND 1 8,740 0 0
VANGUARD HIGH DIVIDEND YIELD ETF ETF 921946406 247 2,430 SH   DFND 1 2,430 0 0
VANGUARD S&P 500 ETF ETF 922908363 6,660 19,200 SH   DFND 1 19,200 0 0
VEEVA SYSTEMS INC-CLASS A CL A 922475108 396 2,000 SH   DFND 1 2,000 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 396 7,800 SH   DFND 1 7,800 0 0
VISA INC CLASS A CL A 92826C839 30,183 153,300 SH   DFND 1 153,300 0 0
VONTIER CORP COM 928881101 1,515 65,906 SH   DFND 1 65,906 0 0
WABTEC CORPORATION COM 929740108 5,871 71,523 SH   DFND 1 71,523 0 0
WATERS CORPORATION COM 941848103 15,420 46,590 SH   DFND 1 46,590 0 0
WELLS FARGO & CO COM 949746101 14,079 359,440 SH   DFND 1 359,440 0 0
XTRACKERS HARVEST CSI 300 CHINA A-SHARES ETF ETF 233051879 400 11,700 SH   DFND 1 11,700 0 0