The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
5 01 ACQUISITION CORP COM CL A 33836P105 7,425 750,000 SH   SOLE   750,000 0 0
89BIO INC COM 282559103 25,060 7,782,669 SH   SOLE   7,782,669 0 0
AADI BIOSCIENCE INC COM 00032Q104 4,719 383,028 SH   SOLE   383,028 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 12,637 5,014,687 SH   SOLE   5,014,687 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 61,403 4,398,453 SH   SOLE   4,398,453 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 45,923 9,770,773 SH   SOLE   9,770,773 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 2,071 1,726,019 SH   SOLE   1,726,019 0 0
AEROVATE THERAPEUTICS INC COM 008064107 129,166 8,263,982 SH   SOLE   8,263,982 0 0
AN2 THERAPEUTICS INC COM 037326105 29,050 3,748,389 SH   SOLE   3,748,389 0 0
ARYA SCIENCES ACQUISITN CLASS A ORD SHS G31658100 9,720 1,000,000 SH   SOLE   1,000,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 703,512 7,567,900 SH   SOLE   7,567,900 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 2,283 760,857 SH   SOLE   760,857 0 0
ATHIRA PHARMA INC COM 04746L104 5,728 1,878,000 SH   SOLE   1,878,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 31,492 2,167,391 SH   SOLE   2,167,391 0 0
AVROBIO INC COM 05455M100 515 559,600 SH   SOLE   559,600 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 12,375 1,250,000 SH   SOLE   1,250,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 94,528 10,230,274 SH   SOLE   10,230,274 0 0
BIOATLA INC COM 09077B104 2,941 1,031,805 SH   SOLE   1,031,805 0 0
BIOGEN INC COM 09062X103 148,269 727,024 SH   SOLE   727,024 0 0
BIOMEA FUSION INC COM 09077A106 5,990 500,000 SH   SOLE   500,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 6,371 2,589,904 SH   SOLE   2,589,904 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 918 450,141 SH   SOLE   450,141 0 0
CALADRIUS BIOSCIENCES COM 128058203 399 752,500 SH   SOLE   752,500 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 55,942 2,075,000 SH   SOLE   2,075,000 0 0
CENTURY THERAPEUTICS INC COM 15673T100 6,357 756,821 SH   SOLE   756,821 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 13,923 3,307,203 SH   SOLE   3,307,203 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 6,082 6,991,003 SH   SOLE   6,991,003 0 0
CVRX INC COM 126638105 1,653 275,000 SH   SOLE   275,000 0 0
CYTEK BIOSCIENCES INC COM 23285D109 143,578 13,381,054 SH   SOLE   13,381,054 0 0
DA32 LIFE SCNCE CLASS A COM 23312M106 14,535 1,500,000 SH   SOLE   1,500,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 126,027 7,040,622 SH   SOLE   7,040,622 0 0
DESIGN THERAPEUTICS INC COM 25056L103 30,613 2,186,636 SH   SOLE   2,186,636 0 0
DICE THERAPEUTICS INC COM 23345J104 80,842 5,208,911 SH   SOLE   5,208,911 0 0
DYNE THERAPEUTICS INC COM 26818M108 19,271 2,805,045 SH   SOLE   2,805,045 0 0
ELIEM THERAPEUTICS INC COM 28658R106 39,716 13,150,849 SH   SOLE   13,150,849 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 42,389 896,724 SH   SOLE   896,724 0 0
ENTERA BIO LTD SHS M40527109 3,129 2,353,000 SH   SOLE   2,353,000 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 26,526 3,370,506 SH   SOLE   3,370,506 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 62,090 9,011,651 SH   SOLE   9,011,651 0 0
FRAZIER LIFESCIENCES ACQU CO CL A SHS G3710A121 9,870 1,000,000 SH   SOLE   1,000,000 0 0
GERON CORP COM 374163103 46,696 30,126,299 SH   SOLE   30,126,299 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 48,886 4,898,373 SH   SOLE   4,898,373 0 0
GUARDANT HEALTH INC COM 40131M109 19,217 476,380 SH   SOLE   476,380 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 6,225 625,000 SH   SOLE   625,000 0 0
HILLEVAX INC COM 43157M102 19,237 1,760,019 SH   SOLE   1,760,019 0 0
ICOSAVAX INC COM 45114M109 34,172 5,963,565 SH   SOLE   5,963,565 0 0
IMMUNOGEN INC COM 45253H101 97,837 21,741,458 SH   SOLE   21,741,458 0 0
INSTIL BIO INC COM 45783C101 35,439 7,670,793 SH   SOLE   7,670,793 0 0
IO BIOTECH INC COM 449778109 8,676 1,857,755 SH   SOLE   1,857,755 0 0
ITEOS THERAPEUTICS INC COM 46565G104 90,996 4,417,259 SH   SOLE   4,417,259 0 0
JANUX THERAPEUTICS INC COM 47103J105 105,869 8,670,644 SH   SOLE   8,670,644 0 0
KINNATE BIOPHARMA INC COM 49705R105 53,771 4,264,144 SH   SOLE   4,264,144 0 0
LARIMAR THERAPEUTICS INC COM 517125100 2,022 1,031,482 SH   SOLE   1,031,482 0 0
LIANBIO SPONSORED ADS 53000N108 9,985 4,622,574 SH   SOLE   4,622,574 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 13,816 2,246,503 SH   SOLE   2,246,503 0 0
NANOSTRING TECHNOLOGIES COM 63009R109 45,523 3,584,478 SH   SOLE   3,584,478 0 0
NATERA INC COM 632307104 46,437 1,310,289 SH   SOLE   1,310,289 0 0
NKARTA INC COM 65487U108 96,159 7,805,129 SH   SOLE   7,805,129 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 952 233,793 SH   SOLE   233,793 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,776 3,040,885 SH   SOLE   3,040,885 0 0
OTONOMY INC COM 68906L105 11,648 5,600,000 SH   SOLE   5,600,000 0 0
PARDES BIOSCIENCES INC COM 69945Q105 18,957 6,175,038 SH   SOLE   6,175,038 0 0
PEPGEN INC COM 713317105 80,750 8,131,952 SH   SOLE   8,131,952 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 24,371 1,710,265 SH   SOLE   1,710,265 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 61,311 9,003,018 SH   SOLE   9,003,018 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 2,269 953,393 SH   SOLE   953,393 0 0
RELAY THERAPEUTICS INC COM 75943R102 9,197 549,055 SH   SOLE   549,055 0 0
RELMADA THERAPEUTICS INC COM 75955J402 37,980 2,000,000 SH   SOLE   2,000,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 20,215 4,871,067 SH   SOLE   4,871,067 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 28,994 2,107,149 SH   SOLE   2,107,149 0 0
RXSIGHT INC COM 78349D107 42,983 3,052,796 SH   SOLE   3,052,796 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 24,485 5,914,252 SH   SOLE   5,914,252 0 0
SENSEI BIOTHERAPEUTICS COM 81728A108 1,642 723,549 SH   SOLE   723,549 0 0
SOLID BIOSCIENCES INC COM 83422E105 7,614 12,367,873 SH   SOLE   12,367,873 0 0
STANDARD BIOTOOLS INC COM 34385P108 3,180 1,987,589 SH   SOLE   1,987,589 0 0
SYNLOGIC INC COM 87166L100 6,700 5,825,858 SH   SOLE   5,825,858 0 0
TENAYA THERAPEUTICS INC COM 87990A106 19,995 3,551,508 SH   SOLE   3,551,508 0 0
TERNS PHARMACEUTICALS INC COM 880881107 3,128 1,261,435 SH   SOLE   1,261,435 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 119,283 4,922,941 SH   SOLE   4,922,941 0 0
TYRA BIOSCIENCES INC COM 90240B106 51,741 7,236,454 SH   SOLE   7,236,454 0 0
VAXCYTE INC COM 92243G108 99,687 4,581,203 SH   SOLE   4,581,203 0 0
VERA THERAPEUTICS INC CL A 92337R101 21,488 1,578,820 SH   SOLE   1,578,820 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 21,369 5,100,000 SH   SOLE   5,100,000 0 0
VERU INC COM 92536C103 89,270 7,900,000 SH   SOLE   7,900,000 0 0
VOR BIOPHARMA INC COM 929033108 55,271 11,120,973 SH   SOLE   11,120,973 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 55,907 17,202,009 SH   SOLE   17,202,009 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 17,554 4,291,881 SH   SOLE   4,291,881 0 0
XILIO THERAPEUTICS INC COM 98422T100 4,817 1,649,711 SH   SOLE   1,649,711 0 0