The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 6,107 80,276 SH   OTR   80,276 0 0
1LIFE HEALTHCARE INC COM 68269G107 443 40,000 SH   OTR   40,000 0 0
ABBOTT LABS COM 002824100 18,641 157,492 SH   OTR   157,492 0 0
ABBVIE INC COM 00287Y109 34,361 211,960 SH   OTR   211,960 0 0
AES CORP COM 00130H105 1,946 75,629 SH   OTR   75,629 0 0
AGCO CORP COM 001084102 1,541 10,555 SH   OTR   10,555 0 0
ALCOA CORP COM 013872106 1,286 14,283 SH   OTR   14,283 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 4,566 501,219 SH   OTR   501,219 0 0
ALLSCRIPTS HEALTHCARE SOLUTN COM 01988P108 19,111 848,645 SH   OTR   848,645 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 13,559 83,038 SH   OTR   83,038 0 0
AMEDISYS INC COM 023436108 11,199 65,000 SH   OTR   65,000 0 0
AMERICAN EXPRESS CO COM 025816109 24,975 133,557 SH   OTR   133,557 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 2,429 14,672 SH   OTR   14,672 0 0
AMERIPRISE FINL INC COM 03076C106 27,326 90,978 SH   OTR   90,978 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 11,242 221,251 SH   OTR   221,251 0 0
APPLE INC COM 037833100 19,200 109,961 SH   OTR   109,961 0 0
APPLIED MATLS INC COM 038222105 1,589 12,053 SH   OTR   12,053 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,783 56,484 SH   OTR   56,484 0 0
AT&T INC COM 00206R102 1,111 47,024 SH   OTR   47,024 0 0
BAKER HUGHES COMPANY CL A 05722G100 1,016 27,918 SH   OTR   27,918 0 0
BAXTER INTL INC COM 071813109 20,258 261,255 SH   OTR   261,255 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 22,503 291,870 SH   OTR   291,870 0 0
BIONTECH SE SPONSORED ADS 09075V102 20,350 119,311 SH   OTR   119,311 0 0
BK OF AMERICA CORP COM 060505104 2,022 49,044 SH   OTR   49,044 0 0
BLACKSTONE INC COM 09260D107 2,084 16,415 SH   OTR   16,415 0 0
BOSTON PROPERTIES INC COM 101121101 2,108 16,363 SH   OTR   16,363 0 0
BOSTON SCIENTIFIC CORP COM 101137107 467 10,551 SH   OTR   10,551 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 26,167 358,298 SH   OTR   358,298 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 1,660 29,346 SH   OTR   29,346 0 0
BRUNSWICK CORP COM 117043109 25,079 310,037 SH   OTR   310,037 0 0
CAREDX INC COM 14167L103 2,166 58,552 SH   OTR   58,552 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 2,336 50,917 SH   OTR   50,917 0 0
CEMEX SAB DE CV SPON ADR NEW 151290889 842 159,126 SH   OTR   159,126 0 0
CERNER CORP COM 156782104 1,738 18,572 SH   OTR   18,572 0 0
CHEMED CORP NEW COM 16359R103 12,664 25,000 SH   OTR   25,000 0 0
CI FINL CORP COM 125491100 27,787 1,750,000 SH   OTR   1,750,000 0 0
CISCO SYS INC COM 17275R102 1,464 26,264 SH   OTR   26,264 0 0
COCA COLA CO COM 191216100 3,290 53,063 SH   OTR   53,063 0 0
COMCAST CORP NEW CL A 20030N101 1,150 24,556 SH   OTR   24,556 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 11,969 190,685 SH   OTR   190,685 0 0
CROWN HLDGS INC COM 228368106 1,384 11,067 SH   OTR   11,067 0 0
CSX CORP COM 126408103 777 20,743 SH   OTR   20,743 0 0
CUMMINS INC COM 231021106 2,082 10,153 SH   OTR   10,153 0 0
CVS HEALTH CORP COM 126650100 34,054 336,467 SH   OTR   336,467 0 0
DANAHER CORPORATION COM 235851102 3,613 12,316 SH   OTR   12,316 0 0
DARLING INGREDIENTS INC COM 237266101 1,148 14,287 SH   OTR   14,287 0 0
DEXCOM INC COM 252131107 15,995 31,264 SH   OTR   31,264 0 0
DISNEY WALT CO COM 254687106 2,198 16,026 SH   OTR   16,026 0 0
EBAY INC. COM 278642103 593 10,349 SH   OTR   10,349 0 0
EDITAS MEDICINE INC COM 28106W103 7,246 380,963 SH   OTR   380,963 0 0
ENBRIDGE INC COM 29250N105 521 11,323 SH   OTR   11,323 0 0
EQUITY LIFESTYLE PPTYS INC COM 29472R108 22,944 300,000 SH   OTR   300,000 0 0
EVERSOURCE ENERGY COM 30040W108 895 10,147 SH   OTR   10,147 0 0
EVOLENT HEALTH INC CL A 30050B101 1,131 35,000 SH   OTR   35,000 0 0
EXACT SCIENCES CORP COM 30063P105 8,545 122,209 SH   OTR   122,209 0 0
EXXON MOBIL CORP COM 30231G102 1,482 17,944 SH   OTR   17,944 0 0
FATE THERAPEUTICS INC COM 31189P102 6,642 171,325 SH   OTR   171,325 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 1,239 12,340 SH   OTR   12,340 0 0
FORD MTR CO DEL COM 345370860 1,805 106,726 SH   OTR   106,726 0 0
FOX CORP CL A COM 35137L105 446 11,305 SH   OTR   11,305 0 0
FREEPORT-MCMORAN INC CL B 35671D857 1,370 27,545 SH   OTR   27,545 0 0
G1 THERAPEUTICS INC COM 3621LQ109 4,121 542,183 SH   OTR   542,183 0 0
GOODRX HLDGS INC COM CL A 38246G108 23,063 1,193,122 SH   OTR   1,193,122 0 0
HALLIBURTON CO COM 406216101 508 13,412 SH   OTR   13,412 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 24,490 614,090 SH   OTR   614,090 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 1,296 27,330 SH   OTR   27,330 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 1,233 20,100 SH   OTR   20,100 0 0
HEWLETT PACKARD ENTERPRISE C COM 42824C109 656 39,273 SH   OTR   39,273 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 1,899 12,514 SH   OTR   12,514 0 0
HOLOGIC INC COM 436440101 26,413 343,825 SH   OTR   343,825 0 0
HP INC COM 40434L105 447 12,309 SH   OTR   12,309 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 4,844 146,828 SH   OTR   146,828 0 0
HYATT HOTELS CORP COM CL A 448579102 2,644 27,700 SH   OTR   27,700 0 0
IMMUNOGEN INC COM 45253H101 10,831 2,275,409 SH   OTR   2,275,409 0 0
INCYTE CORP COM 45337C102 26,407 332,498 SH   OTR   332,498 0 0
INFOSYS LTD SPONSORED ADR 456788108 1,593 64,000 SH   OTR   64,000 0 0
INTEL CORP COM 458140100 1,146 23,117 SH   OTR   23,117 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 5,747 79,089 SH   OTR   79,089 0 0
INTERPUBLIC GROUP COS INC COM 460690100 386 10,902 SH   OTR   10,902 0 0
INVITAE CORP COM 46185L103 6,757 847,825 SH   OTR   847,825 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 6,864 412,262 SH   OTR   412,262 0 0
IQVIA HLDGS INC COM 46266C105 32,268 139,563 SH   OTR   139,563 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 20,238 128,518 SH   OTR   128,518 0 0
ISHARES INC CORE MSCI EMKT 46434G103 2,868 51,633 SH   OTR   51,633 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 7,152 1,252,600 SH   OTR   1,252,600 0 0
JOHNSON & JOHNSON COM 478160104 2,549 14,384 SH   OTR   14,384 0 0
JPMORGAN CHASE & CO COM 46625H100 3,141 23,042 SH   OTR   23,042 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 5,720 776,053 SH   OTR   776,053 0 0
KE HLDGS INC SPONSORED ADS 482497104 800 64,700 SH   OTR   64,700 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 20,653 130,737 SH   OTR   130,737 0 0
KIMCO RLTY CORP COM 49446R109 282 11,422 SH   OTR   11,422 0 0
KINDER MORGAN INC DEL COM 49456B101 797 42,145 SH   OTR   42,145 0 0
KKR & CO INC COM 48251W104 946 16,171 SH   OTR   16,171 0 0
KURA ONCOLOGY INC COM 50127T109 3,769 234,372 SH   OTR   234,372 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 23,918 90,716 SH   OTR   90,716 0 0
LHC GROUP INC COM 50187A107 33,720 200,000 SH   OTR   200,000 0 0
LOWES COS INC COM 548661107 21,092 104,316 SH   OTR   104,316 0 0
LUMEN TECHNOLOGIES INC COM 550241103 208 18,435 SH   OTR   18,435 0 0
MALIBU BOATS INC COM CL A 56117J100 893 15,400 SH   OTR   15,400 0 0
MANULIFE FINL CORP COM 56501R106 12,880 604,270 SH   OTR   604,270 0 0
MARAVAI LIFESCIENCES HLDGS I COM CL A 56600D107 1,305 37,000 SH   OTR   37,000 0 0
MASTEC INC COM 576323109 1,731 19,879 SH   OTR   19,879 0 0
MEDIFAST INC COM 58470H101 29,887 175,000 SH   OTR   175,000 0 0
MERCK & CO INC COM 58933Y105 1,653 20,141 SH   OTR   20,141 0 0
META PLATFORMS INC CL A 30303M102 4,022 18,086 SH   OTR   18,086 0 0
MICRON TECHNOLOGY INC COM 595112103 2,015 25,869 SH   OTR   25,869 0 0
MICROSOFT CORP COM 594918104 15,457 50,133 SH   OTR   50,133 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3,214 39,092 SH   OTR   39,092 0 0
MONDELEZ INTL INC CL A 609207105 663 10,564 SH   OTR   10,564 0 0
NATERA INC COM 632307104 8,088 198,824 SH   OTR   198,824 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 17,866 190,568 SH   OTR   190,568 0 0
NEXTERA ENERGY INC COM 65339F101 2,962 34,963 SH   OTR   34,963 0 0
NEXTGEN HEALTHCARE INC COM 65343C102 1,736 83,000 SH   OTR   83,000 0 0
NIKE INC CL B 654106103 3,796 28,213 SH   OTR   28,213 0 0
NORTONLIFELOCK INC COM 668771108 359 13,546 SH   OTR   13,546 0 0
NRG ENERGY INC COM NEW 629377508 824 21,488 SH   OTR   21,488 0 0
NVIDIA CORPORATION COM 67066G104 5,772 21,153 SH   OTR   21,153 0 0
ORACLE CORP COM 68389X105 947 11,444 SH   OTR   11,444 0 0
PEMBINA PIPELINE CORP COM 706327103 853 22,710 SH   OTR   22,710 0 0
PEPSICO INC COM 713448108 3,778 22,573 SH   OTR   22,573 0 0
PFIZER INC COM 717081103 1,956 37,790 SH   OTR   37,790 0 0
PROCTER AND GAMBLE CO COM 742718109 3,588 23,479 SH   OTR   23,479 0 0
QUANTERIX CORP COM 74766Q101 6,379 218,547 SH   OTR   218,547 0 0
R1 RCM INC COM 749397105 17,649 659,521 SH   OTR   659,521 0 0
ROYAL BK CDA COM 780087102 1,150 10,450 SH   OTR   10,450 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 1,432 259,918 SH   OTR   259,918 0 0
SALESFORCE COM INC COM 79466L302 3,436 16,185 SH   OTR   16,185 0 0
SANGAMO THERAPEUTICS INC COM 800677106 5,001 860,702 SH   OTR   860,702 0 0
SCHLUMBERGER LTD COM STK 806857108 686 16,602 SH   OTR   16,602 0 0
SCHWAB CHARLES CORP COM 808513105 21,805 258,629 SH   OTR   258,629 0 0
SEA LTD SPONSORD ADS 81141R100 1,831 15,288 SH   OTR   15,288 0 0
SERVICE CORP INTL COM 817565104 29,619 450,000 SH   OTR   450,000 0 0
SHOCKWAVE MED INC COM 82489T104 10,107 48,739 SH   OTR   48,739 0 0
SIGNIFY HEALTH INC CL A COM 82671G100 9,572 527,393 SH   OTR   527,393 0 0
SKECHERS U S A INC CL A 830566105 962 23,600 SH   OTR   23,600 0 0
STARBUCKS CORP COM 855244109 1,500 16,487 SH   OTR   16,487 0 0
STEEL DYNAMICS INC COM 858119100 1,158 13,883 SH   OTR   13,883 0 0
SUTRO BIOPHARMA INC COM 869367102 3,214 391,024 SH   OTR   391,024 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 1,825 17,500 SH   OTR   17,500 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 21,718 186,756 SH   OTR   186,756 0 0
TELADOC HEALTH INC COM 87918A105 9,328 129,318 SH   OTR   129,318 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 34,016 57,591 SH   OTR   57,591 0 0
THOR INDS INC COM 885160101 21,643 275,000 SH   OTR   275,000 0 0
TJX COS INC NEW COM 872540109 1,988 32,824 SH   OTR   32,824 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 1,233 15,541 SH   OTR   15,541 0 0
TWIST BIOSCIENCE CORP COM 90184D100 10,602 214,701 SH   OTR   214,701 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 8,446 47,079 SH   OTR   47,079 0 0
UNITEDHEALTH GROUP INC COM 91324P102 33,636 65,956 SH   OTR   65,956 0 0
VANGUARD INTL EQUITY INDEX F TT WRLD ST ETF 922042742 2,413 23,820 SH   OTR   23,820 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 1,517 29,783 SH   OTR   29,783 0 0
VIRTUS INVT PARTNERS INC COM 92828Q109 12,000 50,000 SH   OTR   50,000 0 0
VISA INC COM CL A 92826C839 27,247 122,862 SH   OTR   122,862 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 470 10,494 SH   OTR   10,494 0 0
WEYERHAEUSER CO MTN BE COM NEW 962166104 1,677 44,245 SH   OTR   44,245 0 0
XPENG INC ADS 98422D105 361 13,085 SH   OTR   13,085 0 0
Y-MABS THERAPEUTICS INC COM 984241109 2,635 221,774 SH   OTR   221,774 0 0
YUM CHINA HLDGS INC COM 98850P109 1,316 31,690 SH   OTR   31,690 0 0