SPDR^® Series Trust

One Iron Street

Boston, MA 02210

May 13, 2022

VIA EDGAR

U.S. Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Attention: File Room

File Nos.: 333-57793, 811-08839

Dear Sir/Madam:

Pursuant to Rule 497(j) under the Securities Act of 1933, as amended, please accept this letter as certification that the Prospectus and Statement of Additional Information (“SAI”) for the SPDR MarketAxess Investment Grade 400 Corporate Bond ETF, a series of the above-referenced Registrant, do not differ from the Prospectus and SAI contained in Post-Effective Amendment No. 292 (the “Amendment”) to the Registrant’s Registration Statement on Form N-1A. The Amendment was filed electronically on May 11, 2022 with a designated effective date of May 11, 2022 (Accession No. 0001193125-22-146527).

Any comments or questions with respect to this filing should be directed to my attention at (617) 664-4182.

Sincerely,