The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 38 255 SH   DFND   0 0 255
908 DEVICES INC COM 65443P102 48 1,860 SH   DFND   0 0 1,860
A10 NETWORKS INC COM 002121101 55 3,317 SH   DFND   0 0 3,317
ABBVIE INC COM 00287Y109 86 630 SH   DFND   0 0 630
ACCELERATE DIAGNOSTICS INC COM 00430H102 30 5,895 SH   DFND   0 0 5,895
ACTIVISION BLIZZARD INC COM 00507V109 438 6,485 SH   DFND   0 0 6,485
ACUITY BRANDS INC COM 00508Y102 15 71 SH   DFND   0 0 71
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 51 13,087 SH   DFND   0 0 13,087
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 8 280 SH   DFND   0 0 280
ADOBE SYSTEMS INCORPORATED COM 00724F101 227 397 SH   DFND   0 0 397
ADVANCED DRAIN SYS INC DEL COM 00790R104 18 137 SH   DFND   0 0 137
ADVANCED MICRO DEVICES INC COM 007903107 144 1,000 SH   DFND   0 0 1,000
ADVENT TECHNOLOGIES HOLDNG I COM CL A 00788A105 55 7,746 SH   DFND   0 0 7,746
AERCAP HOLDINGS NV SHS N00985106 144 2,204 SH   DFND   0 0 2,204
AEVA TECHNOLOGIES INC COM 00835Q103 40 5,162 SH   DFND   0 0 5,162
AFYA LTD CL A COM G01125106 13,824 911,298 SH   DFND   73,239 0 838,059
AGILENT TECHNOLOGIES INC COM 00846U101 178 1,108 SH   DFND   0 0 1,108
AGILYSYS INC COM 00847J105 46 1,049 SH   DFND   0 0 1,049
AIR PRODS & CHEMS INC COM 009158106 215 706 SH   DFND   0 0 706
AIRBNB INC COM 009066101 28 163 SH   DFND   0 0 163
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 15,566 126,562 SH   DFND   0 0 126,562
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 170 996 SH   DFND   0 0 996
ALPHABET INC CAP STK CL A 02079K305 26,350 9,013 SH   DFND   148 0 8,865
ALPHABET INC CAP STK CL C 02079K107 20,639 7,068 SH   DFND   0 0 7,068
AMAZON COM INC COM 023135106 29,645 8,797 SH   DFND   695 0 8,102
AMBARELLA INC SHS G037AX101 46 231 SH   DFND   0 0 231
AMBEV SA SPONSORED ADR 02319V103 32,368 11,754,196 SH   DFND   144,600 0 11,609,596
AMCOR PLC ORD G0250X107 0 1 SH   DFND   0 0 1
AMERICA MOVIL SAB DE CV SPON ADR L SHS 02364W105 72,690 3,517,728 SH   DFND   390,936 0 3,126,792
AMERICAN WTR WKS CO INC NEW COM 030420103 67 354 SH   DFND   0 0 354
AMGEN INC COM 031162100 82 360 SH   DFND   0 0 360
ANALOG DEVICES INC COM 032654105 72 412 SH   DFND   0 0 412
ANTHEM INC COM 036752103 21 46 SH   DFND   0 0 46
APELLIS PHARMACEUTICALS INC COM 03753U106 8 163 SH   DFND   0 0 163
APPLE INC COM 037833100 16,366 91,842 SH   DFND   483 0 91,359
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 50 1,274 SH   DFND   0 0 1,274
ARENA PHARMACEUTICALS INC COM NEW 040047607 23 249 SH   DFND   0 0 249
ARMSTRONG WORLD INDS INC NEW COM 04247X102 13 112 SH   DFND   0 0 112
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 15 228 SH   DFND   0 0 228
ASANA INC CL A 04342Y104 48 626 SH   DFND   0 0 626
ASE TECHNOLOGY HOLDING CO LT SPONSORED ADS 00215W100 3,621 34,000 SH   DFND   34,000 0 0
ASENSUS SURGICAL INC COM COM 04367G103 38 35,547 SH   DFND   0 0 35,547
ASML HOLDING N V N Y REGISTRY SHS N07059210 398 500 SH   DFND   0 0 500
ASTRAZENECA PLC SPONSORED ADR 046353108 4,290 73,643 SH   DFND   0 0 73,643
AUTONATION INC COM 05329W102 103 891 SH   DFND   0 0 891
BAIDU INC SPON ADR REP A 056752108 16,380 108,757 SH   DFND   0 0 108,757
BALLARD PWR SYS INC NEW COM 058586108 191 15,108 SH   DFND   0 0 15,108
BANCO BRADESCO S A SP ADR PFD NEW 059460303 87,353 26,069,330 SH   DFND   4,256,676 0 21,812,654
BANCO DE CHILE SPONSORED ADS 059520106 7,571 481,892 SH   DFND   0 0 481,892
BANCO SANTANDER BRASIL S A ADS REP 1 UNIT 05967A107 1,350 251,400 SH   DFND   0 0 251,400
BANCO SANTANDER CHILE NEW SP ADR REP COM 05965X109 3,188 222,534 SH   DFND   0 0 222,534
BANCOLOMBIA S A SPON ADR PREF 05968L102 16,709 528,933 SH   DFND   0 0 528,933
BANK AMER CORP PUT 060505954 360 2,500 SH Put DFND   0 0 2,500
BEAM THERAPEUTICS INC COM 07373V105 91 1,110 SH   DFND   0 0 1,110
BEST BUY INC COM 086516101 5,562 54,740 SH   DFND   54,740 0 0
BEYOND MEAT INC COM 08862E109 11 161 SH   DFND   0 0 161
BIGCOMMERCE HLDGS INC COM SER 1 08975P108 42 1,170 SH   DFND   0 0 1,170
BIO TECHNE CORP COM 09073M104 185 363 SH   DFND   0 0 363
BIOGEN INC COM 09062X103 78 327 SH   DFND   0 0 327
BIOMARIN PHARMACEUTICAL INC COM 09061G101 77 869 SH   DFND   0 0 869
BIT MINING LIMITED SPON ADR REP A 055474100 47 7,328 SH   DFND   0 0 7,328
BLOOM ENERGY CORP COM CL A 093712107 154 7,047 SH   DFND   0 0 7,047
BOEING CO COM 097023105 283,752 1,400 SH   SOLE   1,400 0 0
BOOKING HOLDINGS INC COM 09857L108 3,158 1,318 SH   DFND   0 0 1,318
BORGWARNER INC COM 099724106 12 269 SH   DFND   0 0 269
BOSTON PROPERTIES INC COM 101121101 27 235 SH   DFND   0 0 235
BP PLC SPONSORED ADR 055622104 1,663 62,300 SH   DFND   0 0 62,300
BRISTOL MYERS SQUIBB CO COM 110122108 83 1,333 SH   DFND   0 0 1,333
BROADCOM INC COM 11135F101 169 254 SH   DFND   0 0 254
BRUKER CORP COM 116794108 34 400 SH   DFND   0 0 400
BUTTERFLY NETWORK INC COM CL A 124155102 44 6,492 SH   DFND   0 0 6,492
C3 AI INC CL A 12468P104 48 1,475 SH   DFND   0 0 1,475
CANAAN INC SPONSORED ADS 134748102 40 7,918 SH   DFND   0 0 7,918
CANADIAN PAC RY LTD COM 13645T100 72 1,006 SH   DFND   0 0 1,006
CAPITAL ONE FINL CORP COM 14040H105 146 1,001 SH   DFND   0 0 1,001
CATALENT INC COM 148806102 101 785 SH   DFND   0 0 785
CATHAY GEN BANCORP COM 149150104 5,063 81,000 SH   DFND   81,000 0 0
CBRE GROUP INC CL A 12504L109 82 752 SH   DFND   0 0 752
CEMEX SAB DE CV SPON ADR NEW 151290889 112,524 17,099,973 SH   DFND   1,574,144 0 15,525,829
CHARGEPOINT HOLDINGS INC COM CL A 15961R105 46 2,389 SH   DFND   0 0 2,389
CHART INDS INC COM PAR $0.01 16115Q308 186 1,171 SH   DFND   0 0 1,171
CHARTER COMMUNICATIONS INC N CL A 16119P108 74 113 SH   DFND   0 0 113
CHEMOURS CO COM 163851108 179 5,382 SH   DFND   0 0 5,382
CHEVRON CORP NEW COM 166764100 31,706 270,000 SH   DFND   0 0 270,000
CISCO SYS INC COM 17275R102 2,433 38,377 SH   DFND   34,500 0 3,877
CISCO SYS INC PUT 17275R952 322 2,500 SH Put DFND   0 0 2,500
CITRIX SYS INC COM 177376100 49 514 SH   DFND   0 0 514
CLEAN HARBORS INC COM 184496107 11 112 SH   DFND   0 0 112
COCA COLA CO COM 191216100 67 1,142 SH   DFND   0 0 1,142
COINBASE GLOBAL INC COM CL A 19260Q107 535 2,120 SH   DFND   2,120 0 0
COMCAST CORP NEW CL A 20030N101 93 1,834 SH   DFND   0 0 1,834
COMPANHIA BRASILEIRA DE DIST SPONSORED ADR 20440T300 486 124,042 SH   DFND   0 0 124,042
COMPANIA DE MINAS BUENAVENTU SPONSORED ADR 204448104 6,803 929,362 SH   DFND   0 0 929,362
CONSOLIDATED EDISON INC COM 209115104 34 395 SH   DFND   0 0 395
CORTEVA INC COM 22052L104 174 3,697 SH   DFND   0 0 3,697
COSTCO WHSL CORP NEW COM 22160K105 12,579 22,306 SH   DFND   0 0 22,306
CREDICORP LTD COM G2519Y108 136,823 1,140,583 SH   DFND   63,962 0 1,076,621
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 154 1,954 SH   DFND   0 0 1,954
CUMMINS INC COM 231021106 197 904 SH   DFND   0 0 904
CYTOKINETICS INC COM NEW 23282W605 9 207 SH   DFND   0 0 207
D R HORTON INC COM 23331A109 158 1,467 SH   DFND   0 0 1,467
DANAHER CORP DEL COM 235851102 378 1,150 SH   DFND   0 0 1,150
DARLING INGREDIENTS INC COM 237266101 25 365 SH   DFND   0 0 365
DENALI THERAPEUTICS INC COM 24823R105 88 1,948 SH   DFND   0 0 1,948
DESKTOP METAL INC COM CL A 25058X105 41 8,058 SH   DFND   0 0 8,058
DISCOVER FINL SVCS COM 254709108 153 1,320 SH   DFND   0 0 1,320
DISNEY WALT CO COM DISNEY 254687106 612 3,941 SH   DFND   2,387 0 1,554
DOLLAR GEN CORP NEW COM 256677105 22 93 SH   DFND   0 0 93
DOORDASH INC CL A 25809K105 70 457 SH   DFND   0 0 457
DOVER CORP COM 260003108 68 375 SH   DFND   0 0 375
DROPBOX INC CL A 26210C104 50 2,032 SH   DFND   0 0 2,032
DUPONT DE NEMOURS INC COM 26614N102 11 132 SH   DFND   0 0 132
EATON CORP PLC SHS G29183103 86 501 SH   DFND   0 0 501
EBANG INTL HLDGS INC CL A SHS G3R33A106 34 35,050 SH   DFND   0 0 35,050
EBAY INC COM 278642103 29 431 SH   DFND   0 0 431
ECOPETROL S A SPONSORED ADS 279158109 9,986 774,678 SH   DFND   0 0 774,678
EDITAS MEDICINE INC COM 28106W103 11 388 SH   DFND   0 0 388
EDWARDS LIFESCIENCES CORP COM 28176E108 84 643 SH   DFND   0 0 643
ELECTRAMECCANICA VEHS CORP COM NEW 284849205 42 17,464 SH   DFND   0 0 17,464
ELECTRONIC ARTS INC COM 285512109 249 1,855 SH   DFND   0 0 1,855
ENERGY RECOVERY INC COM 29270J100 50 2,344 SH   DFND   0 0 2,344
ENERGY TRANSFER EQUITY L P COM UT LTD PTN 29273V100 40 4,922 SH   DFND   0 0 4,922
ENTEGRIS INC COM 29362U104 49 357 SH   DFND   0 0 357
EOG RES INC COM 26875P101 151 1,697 SH   DFND   0 0 1,697
EOS ENERGY ENTERPRISES INC COM CL A 29415C101 45 5,788 SH   DFND   0 0 5,788
EPAM SYS INC COM 29414B104 201 300 SH   DFND   0 0 300
ESSENTIAL UTILS INC COM 29670G102 17 313 SH   DFND   0 0 313
EXACT SCIENCES CORP COM 30063P105 49 633 SH   DFND   0 0 633
EXELIXIS INC COM 30161Q104 105 5,618 SH   DFND   0 0 5,618
EXXON MOBIL CORP COM 30231G102 17,964 295,506 SH   DFND   0 0 295,506
FACEBOOK INC CL A 30303M102 56,170 165,440 SH   DFND   100,000 0 65,440
FACEBOOK INC PUT 30303M952 388 1,000 SH Put DFND   0 0 1,000
FATE THERAPEUTICS INC COM 31189P102 17 283 SH   DFND   0 0 283
FIDELITY NATL INFORMATION SV COM 31620M106 21 195 SH   DFND   0 0 195
FIRST SOLAR INC COM 336433107 23 262 SH   DFND   0 0 262
FISERV INC COM 337738108 24 228 SH   DFND   0 0 228
FOMENTO ECONOMICO MEXICANO S SPON ADR UNITS 344419106 96,962 1,285,157 SH   DFND   112,961 0 1,172,196
FOOT LOCKER INC COM 344849104 93 2,116 SH   DFND   0 0 2,116
FORD MTR CO DEL COM PAR $0.01 345370860 0 1 SH   DFND   0 0 1
FREEPORT-MCMORAN INC CL B 35671D857 12,320 296,000 SH   DFND   0 0 296,000
FUELCELL ENERGY INC COM 35952H601 122 22,900 SH   DFND   0 0 22,900
GENERAL MLS INC COM 370334104 19 282 SH   DFND   0 0 282
GENERAL MTRS CO COM 37045V100 198 3,406 SH   DFND   0 0 3,406
GENUINE PARTS CO COM 372460105 69 493 SH   DFND   0 0 493
GEOPARK LTD USD SHS G38327105 3,840 335,387 SH   DFND   0 0 335,387
GERDAU SA SPON ADR REP PFD 373737105 48,378 10,036,257 SH   DFND   911,085 0 9,125,172
GILEAD SCIENCES INC COM 375558103 325 4,468 SH   DFND   3,367 0 1,101
GLOBAL X FDS LITHIUM BTRY ETF 37954Y855 6,199 73,000 SH   DFND   0 0 73,000
GLOBANT S A COM L44385109 11,148 38,637 SH   DFND   0 0 38,637
GOLDMAN SACHS GROUP INC COM 38141G104 146 378 SH   DFND   0 0 378
GRAPHIC PACKAGING HLDG CO COM 388689101 13 664 SH   DFND   0 0 664
GRITSTONE ONCOLOGY INC COM 39868T105 53 4,058 SH   DFND   0 0 4,058
GRUPO AEROPORTUARIO DEL CENT SPON ADR 400501102 3,808 71,058 SH   DFND   2,851 0 68,207
GRUPO AEROPORTUARIO DEL SURE SPON ADR SER B 40051E202 25,174 124,230 SH   DFND   13,371 0 110,859
GRUPO AVAL ACCIONES Y VALORE SPONSORED ADS 40053W101 3,196 625,476 SH   DFND   0 0 625,476
GRUPO TELEVISA SA SPON ADR REP ORD 40049J206 9,019 964,872 SH   DFND   124,083 0 840,789
GUARDANT HEALTH INC COM 40131M109 130 1,293 SH   DFND   0 0 1,293
HALLIBURTON CO COM 406216101 133 5,855 SH   DFND   0 0 5,855
HASBRO INC COM 418056107 127 1,260 SH   DFND   0 0 1,260
HDFC BANK LTD ADR REPS 3 SHS 40415F101 410 6,300 SH   DFND   0 0 6,300
HEWLETT PACKARD ENTERPRISE C COM 42824C109 62 3,916 SH   DFND   0 0 3,916
HEXCEL CORP NEW COM 428291108 11 221 SH   DFND   0 0 221
HOLOGIC INC COM 436440101 35 461 SH   DFND   0 0 461
HONEYWELL INTL INC COM 438516106 63 306 SH   DFND   0 0 306
HORIZON THERAPEUTICS PUB L SHS G46188101 45 419 SH   DFND   0 0 419
HP INC COM 40434L105 0 1 SH   DFND   0 0 1
HUMANA INC COM 444859102 21 44 SH   DFND   0 0 44
HYSTER YALE MATLS HANDLING I CL A 449172105 90 2,210 SH   DFND   0 0 2,210
IDACORP INC COM 451107106 12 108 SH   DFND   0 0 108
ILLUMINA INC COM 452327109 181 472 SH   DFND   0 0 472
IMMUNITYBIO INC COM 45256X103 51 7,943 SH   DFND   0 0 7,943
INCYTE CORP COM 45337C102 111 1,503 SH   DFND   0 0 1,503
INFOSYS LTD SPONSORED ADR 456788108 679 26,811 SH   DFND   0 0 26,811
INOVIO PHARMACEUTICALS INC COM NEW 45773H201 39 7,548 SH   DFND   0 0 7,548
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 17 243 SH   DFND   0 0 243
INTELLIA THERAPEUTICS INC COM 45826J105 127 1,045 SH   DFND   0 0 1,045
INTERCONTINENTAL EXCHANGE IN COM 45866F104 8,288 60,592 SH   DFND   0 0 60,592
INTL PAPER CO COM 460146103 38 810 SH   DFND   0 0 810
INTRA CELLULAR THERAPIES INC COM 46116X101 6 112 SH   DFND   0 0 112
INTUITIVE SURGICAL INC COM NEW 46120E602 82 225 SH   DFND   0 0 225
INVITAE CORP COM 46185L103 11 678 SH   DFND   0 0 678
IONIS PHARMACEUTICALS INC COM 462222100 86 2,804 SH   DFND   0 0 2,804
IQVIA HLDGS INC COM 46266C105 106 374 SH   DFND   0 0 374
ISHARES INC MSCI BRAZIL ETF 464286400 9,734 348,250 SH   DFND   0 0 348,250
ISHARES INC MSCI HONG KG ETF 464286871 821 35,400 SH   DFND   0 0 35,400
ISHARES INC MSCI JPN ETF NEW 46434G822 61,467 918,025 SH   DFND   836,105 0 81,920
ISHARES INC MSCI TAIWAN ETF 46434G772 1,865 28,000 SH   DFND   0 0 28,000
ISHARES INC PUT 464286950 3,158 5,000 SH Put DFND   0 0 5,000
ISHARES INC PUT 464286951 100 2,500 SH Put DFND   0 0 2,500
ISHARES INC PUT 46434G952 373 1,500 SH Put DFND   0 0 1,500
ISHARES INC MSCI PAC JP ETF 464286665 326 6,800 SH   DFND   0 0 6,800
ISHARES INC MSCI CDA ETF 464286509 3,759 98,270 SH   DFND   0 0 98,270
ISHARES INC MSCI STH KOR ETF 464286772 1,915 24,500 SH   DFND   0 0 24,500
ISHARES INC CORE MSCI EMKT 46434G103 648 10,800 SH   DFND   0 0 10,800
ISHARES INC MSCI EM ASIA ETF 464286426 1,567 19,000 SH   DFND   0 0 19,000
ISHARES INC MSCI GERMANY ETF 464286806 34 1,032 SH   DFND   0 0 1,032
ISHARES INC JP MRG EM CRP BD 464286251 6,962 136,500 SH   DFND   136,500 0 0
ISHARES TR CHINA LG-CAP ETF 464287184 15,239 416,565 SH   DFND   0 0 416,565
ISHARES TR MSCI EAFE ETF 464287465 4,119 52,350 SH   DFND   0 0 52,350
ISHARES TR MSCI EMG MKT ETF 464287234 25,251 516,900 SH   DFND   200,100 0 316,800
ISHARES TR PUT 464287956 466 3,500 SH Put DFND   0 0 3,500
ISHARES TR PUT 464287955 848 6,670 SH Put DFND   0 0 6,670
ISHARES TR PUT 464287954 2,334 19,000 SH Put DFND   0 0 19,000
ISHARES TR RUSSELL 2000 ETF 464287655 3,103 13,951 SH   DFND   0 0 13,951
ISHARES TR MSCI ACWI ETF 464288257 4,609 43,500 SH   DFND   0 0 43,500
ISHARES TR MSCI CHINA ETF 46429B671 3,031 48,000 SH   DFND   0 0 48,000
ISHARES TR JPMORGAN USD EMG 464288281 5,128 47,000 SH   DFND   32,000 0 15,000
ISHARES TR IBOXX HI YD ETF 464288513 6,265 72,000 SH   DFND   72,000 0 0
ISHARES TR IBOXX INV CP ETF 464287242 6,387 48,198 SH   DFND   48,198 0 0
ISHARES TR S&P 500 VAL ETF 464287408 4,624 29,500 SH   DFND   0 0 29,500
ISHARES TR SHORT TREAS BD 464288679 313 2,836 SH   DFND   2,836 0 0
ISHARES TR 10-20 YR TRS ETF 464288653 4,558 30,716 SH   DFND   30,716 0 0
ISHARES TR US TREAS BD ETF 46429B267 3,737 140,073 SH   DFND   140,073 0 0
ISHARES TR MSCI INDIA ETF 46429B598 4,128 90,050 SH   DFND   0 0 90,050
ISHARES TR RUS 1000 VAL ETF 464287598 132 785 SH   DFND   0 0 785
ISHARES TR EUROPE ETF 464287861 1,197 22,000 SH   DFND   0 0 22,000
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 77,200 21,006,360 SH   DFND   2,319,495 0 18,686,865
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 78 609 SH   DFND   0 0 609
JEFFERIES FINL GROUP INC COM 47233W109 119 3,059 SH   DFND   0 0 3,059
JOHNSON & JOHNSON COM 478160104 623 3,634 SH   DFND   2,222 0 1,412
JOHNSON CTLS INTL PLC SHS G51502105 78 969 SH   DFND   0 0 969
JPMORGAN CHASE & CO COM 46625H100 30,467 192,243 SH   DFND   0 0 192,243
JUNIPER NETWORKS INC COM 48203R104 55 1,546 SH   DFND   0 0 1,546
KEYSIGHT TECHNOLOGIES INC COM 49338L103 71 342 SH   DFND   0 0 342
KKR & CO INC CL A 48251W104 8,411 112,498 SH   DFND   0 0 112,498
L3HARRIS TECHNOLOGIES INC COM 502431109 65 304 SH   DFND   0 0 304
LABORATORY CORP AMER HLDGS COM NEW 50540R409 242 773 SH   DFND   0 0 773
LAM RESEARCH CORP COM 512807108 20 28 SH   DFND   0 0 28
LENDINGCLUB CORP COM NEW 52603A208 39 1,580 SH   DFND   0 0 1,580
LENNAR CORP CL A 526057104 154 1,337 SH   DFND   0 0 1,337
LILLY ELI & CO COM 532457108 87 314 SH   DFND   0 0 314
LINDE PLC COM G5494J103 4,513 13,107 SH   DFND   0 0 13,107
LKQ CORP COM 501889208 67 1,136 SH   DFND   0 0 1,136
LOUISIANA PAC CORP COM 546347105 146 1,877 SH   DFND   0 0 1,877
LOWES COS INC COM 548661107 119 463 SH   DFND   0 0 463
LULULEMON ATHLETICA INC COM 550021109 29 72 SH   DFND   0 0 72
LUMINAR TECHNOLOGIES INC COM CL A 550424105 54 3,102 SH   DFND   0 0 3,102
LUXFER HOLDINGS PLC SHS G5698W116 47 2,452 SH   DFND   0 0 2,452
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 157 1,700 SH   DFND   0 0 1,700
MARAVAI LIFESCIENCES HLDGS I COM CL A 56600D107 28 659 SH   DFND   0 0 659
MASCO CORP COM 574599106 28 395 SH   DFND   0 0 395
MASIMO CORP COM 574795100 80 268 SH   DFND   0 0 268
MCDONALDS CORP COM 580135101 116 435 SH   DFND   0 0 435
MEDPACE HLDGS INC COM 58506Q109 37 171 SH   DFND   0 0 171
MERCADOLIBRE INC COM 58733R102 5,690 4,196 SH   DFND   0 0 4,196
MERCK & CO INC COM 58933Y105 231 2,991 SH   DFND   0 0 2,991
MICRON TECHNOLOGY INC COM 595112103 337 3,589 SH   DFND   0 0 3,589
MICROSOFT CORP COM 594918104 24,245 71,505 SH   DFND   5,964 0 65,541
MICROVISION INC DEL COM NEW 594960304 36 7,000 SH   DFND   0 0 7,000
MIRATI THERAPEUTICS INC COM 60468T105 32 215 SH   DFND   0 0 215
MODERNA INC COM 60770K107 242 960 SH   DFND   0 0 960
MONDELEZ INTL INC CL A 609207105 39 586 SH   DFND   0 0 586
MOTOROLA SOLUTIONS INC COM NEW 620076307 72 264 SH   DFND   0 0 264
MYRIAD GENETICS INC COM 62855J104 81 2,927 SH   DFND   0 0 2,927
NANO DIMENSION LTD SPONSORD ADS NEW 63008G203 42 10,802 SH   DFND   0 0 10,802
NATERA INC COM 632307104 38 411 SH   DFND   0 0 411
NEOGENOMICS INC COM NEW 64049M209 19 561 SH   DFND   0 0 561
NETEASE INC SPONSORED ADR 64110W102 245 2,365 SH   DFND   0 0 2,365
NETFLIX INC COM 64110L106 20,618 33,719 SH   DFND   2,135 0 31,584
NETSCOUT SYS INC COM 64115T104 53 1,594 SH   DFND   0 0 1,594
NEXTERA ENERGY INC COM 65339F101 1,451 15,544 SH   DFND   15,544 0 0
NIKE INC CL B 654106103 173 1,033 SH   DFND   228 0 805
NIKOLA CORP COM 654110105 190 18,608 SH   DFND   0 0 18,608
NOVAVAX INC COM NEW 670002401 35 228 SH   DFND   0 0 228
NUCOR CORP COM 670346105 152 1,338 SH   DFND   0 0 1,338
NVIDIA CORP COM 67066G104 76,723 260,529 SH   DFND   203,316 0 57,213
NVIDIA CORP PUT 67066G954 4,606 2,000 SH Put DFND   0 0 2,000
NXP SEMICONDUCTORS N V NOTE 1.000%12/0 62952QAB6 12 53 SH   DFND   0 0 53
O REILLY AUTOMOTIVE INC NEW COM 67103H107 4,421 6,300 SH   DFND   0 0 6,300
OLIN CORP COM PAR $1 680665205 315 5,493 SH   DFND   0 0 5,493
ONECONNECT FINL TECHNOLOGY C SPONSORD ADS 68248T105 50 19,889 SH   DFND   0 0 19,889
ONEOK INC NEW COM 682680103 138 2,368 SH   DFND   0 0 2,368
OUSTER INC COM 68989M103 41 7,687 SH   DFND   0 0 7,687
OWENS CORNING NEW COM 690742101 12 134 SH   DFND   0 0 134
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 23 1,113 SH   DFND   0 0 1,113
PAYPAL HLDGS INC COM 70450Y103 275 1,443 SH   DFND   703 0 740
PENTAIR PLC SHS G7S00T104 17 230 SH   DFND   0 0 230
PEPSICO INC COM 713448108 79 457 SH   DFND   0 0 457
PERKINELMER INC COM 714046109 128 640 SH   DFND   0 0 640
PETROLEO BRASILEIRO SA PETRO PUT 71654V958 252 635 SH Put DFND   0 0 635
PETROLEO BRASILEIRO SA PETRO SP ADR NON VTG 71654V101 31,673 3,149,459 SH   DFND   1,236,733 0 1,912,726
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 128,109 11,916,324 SH   DFND   1,627,211 0 10,289,113
PFIZER INC COM 717081103 542 9,276 SH   DFND   0 0 9,276
PG&E CORP COM 69331C108 18 1,527 SH   DFND   0 0 1,527
PLUG POWER INC COM NEW 72919P202 189 6,547 SH   DFND   0 0 6,547
PROCAPS GROUP S A SHS L7756P102 2,861 297,974 SH   DFND   0 0 297,974
PROQR THRAPEUTICS N V SHS EURO N71542109 57 6,971 SH   DFND   0 0 6,971
QUALCOMM INC COM 747525103 72 392 SH   DFND   0 0 392
QUEST DIAGNOSTICS INC COM 74834L100 116 678 SH   DFND   0 0 678
QUIDEL CORP COM 74838J101 29 221 SH   DFND   0 0 221
RAYONIER INC COM 754907103 12 300 SH   DFND   0 0 300
RECURSION PHARMACEUTICALS IN CL A 75629V104 44 2,530 SH   DFND   0 0 2,530
REGENERON PHARMACEUTICALS COM 75886F107 75 117 SH   DFND   0 0 117
REPUBLIC SVCS INC COM 760759100 58 422 SH   DFND   0 0 422
RIDGEBIO PHARMA INC COM COM 10806X102 3 203 SH   DFND   0 0 203
ROBLOX CORP CL A 771049103 246 2,444 SH   DFND   0 0 2,444
ROMEO POWER INC COM 776153108 46 12,077 SH   DFND   0 0 12,077
ROSS STORES INC COM 778296103 1,844 16,137 SH   DFND   0 0 16,137
ROYAL DUTCH SHELL PLC SPONS ADR A 780259206 154 3,541 SH   DFND   0 0 3,541
S&P GLOBAL INC COM 78409V104 104 220 SH   DFND   0 0 220
SALESFORCE COM INC COM 79466L302 4,245 16,624 SH   DFND   0 0 16,624
SAREPTA THERAPEUTICS INC COM 803607100 26 283 SH   DFND   0 0 283
SCHWAB CHARLES CORP NEW COM 808513105 10,346 122,472 SH   DFND   0 0 122,472
SEA LTD ADR 81141R100 612 2,732 SH   DFND   0 0 2,732
SEAGEN INC COM 81181C104 81 513 SH   DFND   0 0 513
SELECT SECTOR SPDR TR ENERGY 81369Y506 5,370 97,000 SH   DFND   0 0 97,000
SELECT SECTOR SPDR TR PUT 81369Y953 1,906 10,000 SH Put DFND   0 0 10,000
SELECT SECTOR SPDR TR PUT 81369Y956 294 3,000 SH Put DFND   0 0 3,000
SELECT SECTOR SPDR TR PUT 81369Y957 44 2,500 SH Put DFND   0 0 2,500
SELECT SECTOR SPDR TR PUT 81369Y954 1,184 8,000 SH Put DFND   0 0 8,000
SELECT SECTOR SPDR TR PUT 81369Y950 2,112 19,000 SH Put DFND   0 0 19,000
SELECT SECTOR SPDR TR PUT 81369Y955 597 7,500 SH Put DFND   0 0 7,500
SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 3,195 81,804 SH   DFND   0 0 81,804
SELECT SECTOR SPDR TR TECHNOLOGY 81369Y803 10,576 60,828 SH   DFND   0 0 60,828
SELECT SECTOR SPDR TR SBI INT-UTILS 81369Y886 2,040 28,500 SH   DFND   0 0 28,500
SELECT SECTOR SPDR TR SBI INT-INDS 81369Y704 12,796 120,930 SH   DFND   0 0 120,930
SELECT SECTOR SPDR TR SBI CONS DISCR 81369Y407 334 1,633 SH   DFND   0 0 1,633
SELECT SECTOR SPDR TR SBI CONS STPLS 81369Y308 183 2,370 SH   DFND   0 0 2,370
SELECT SECTOR SPDR TR SBI MATERIALS 81369Y100 15,213 167,900 SH   DFND   0 0 167,900
SELECT SECTOR SPDR TR RL EST SEL SEC 81369Y860 2,517 48,580 SH   DFND   0 0 48,580
SERVICENOW INC COM 81762P102 87 133 SH   DFND   0 0 133
SILICON LABORATORIES INC COM 826919102 51 245 SH   DFND   0 0 245
SL GREEN RLTY CORP COM 78440X804 12 163 SH   DFND   0 0 163
SOCIEDAD QUIMICA MINERA DE C SPON ADR SER B 833635105 23,994 476,431 SH   DFND   33,121 0 443,310
SONOS INC COM 83570H108 2,699 90,000 SH   DFND   0 0 90,000
SONY CORP SPONSORED ADR 835699307 605 4,788 SH   DFND   0 0 4,788
SOUTHERN COPPER CORP COM 84265V105 31,024 502,740 SH   DFND   0 0 502,740
SPDR GOLD TR GOLD SHS 78463V107 3,009 17,600 SH   DFND   0 0 17,600
SPDR INDEX SHS FDS ASIA PACIF ETF 78463X301 2,500 20,500 SH   DFND   0 0 20,500
SPDR S&P 500 ETF TR PUT 78462F953 1,238 4,695 SH Put DFND   0 0 4,695
SPDR S&P 500 ETF TR TR UNIT 78462F103 347,142 730,959 SH   DFND   730,959 0 0
SPDR SER TR S&P OILGAS EXP 78468R556 2,068 21,500 SH   DFND   0 0 21,500
SPDR SERIES TRUST S&P METALS MNG 78464A755 291 6,500 SH   DFND   0 0 6,500
SQUARE INC CL A 852234103 36 219 SH   DFND   0 0 219
STARBUCKS CORP COM 855244109 5,585 48,046 SH   DFND   0 0 48,046
STEEL DYNAMICS INC COM 858119100 25 400 SH   DFND   0 0 400
STELLANTIS N.V COM N82405106 188 10,016 SH   DFND   0 0 10,016
STEM INC COM 85859N102 49 2,546 SH   DFND   0 0 2,546
STERICYCLE INC COM 858912108 12 201 SH   DFND   0 0 201
SUNRUN INC COM 86771W105 14 407 SH   DFND   0 0 407
SUZANO S A SPON COM 86959K105 34,224 3,177,824 SH   DFND   428,006 0 2,749,818
SYNCHRONY FINL COM 87165B103 131 2,835 SH   DFND   0 0 2,835
SYNNEX CORP COM 87162W100 861 13,000 SH   DFND   13,000 0 0
SYNOPSYS INC COM 871607107 69 187 SH   DFND   0 0 187
T MOBILE US INC COM 872590104 2,329 19,989 SH   DFND   0 0 19,989
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 73,687 123,169 SH   DFND   0 0 123,169
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 248 1,372 SH   DFND   0 0 1,372
TARGET CORP COM 87612E106 2,716 11,710 SH   DFND   0 0 11,710
TECHNIPFMC PLC COM G87110105 126 21,528 SH   DFND   0 0 21,528
TELADOC HEALTH INC COM 87918A105 76 808 SH   DFND   0 0 808
TESLA INC COM 88160R101 17,936 16,757 SH   DFND   0 0 16,757
TEXTRON INC COM 883203101 68 882 SH   DFND   0 0 882
THE TRADE DESK INC COM CL A 88339J105 27 288 SH   DFND   0 0 288
THERMO FISHER SCIENTIFIC INC COM 883556102 361 542 SH   DFND   0 0 542
TIM S A COM 88706T108 9,369 807,953 SH   DFND   158,231 0 649,722
TOPBUILD CORP COM 89055F103 18 65 SH   DFND   0 0 65
TRACTOR SUPPLY CO COM 892356106 68 289 SH   DFND   0 0 289
TREX CO INC COM 89531P105 33 249 SH   DFND   0 0 249
TUSIMPLE HLDGS INC CL A 90089L108 44 1,259 SH   DFND   0 0 1,259
TWILIO INC CL A 90138F102 29 111 SH   DFND   0 0 111
TWIST BIOSCIENCE CORP COM 90184D100 20 252 SH   DFND   0 0 252
TWITTER INC COM 90184L102 20 448 SH   DFND   0 0 448
TYSON FOODS INC CL A 902494103 233 2,694 SH   DFND   0 0 2,694
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 11 133 SH   DFND   0 0 133
UNITED MICROELECTRONICS CORP SPON ADR NEW 910873405 7,410 114,000 SH   DFND   114,000 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 85 396 SH   DFND   0 0 396
UNITEDHEALTH GROUP INC COM 91324P102 221 438 SH   DFND   0 0 438
UNIVERSAL DISPLAY CORP COM 91347P105 38 229 SH   DFND   0 0 229
VALE S A SPONSORED ADS 91912E105 101,031 7,326,007 SH   DFND   1,342,505 0 5,983,502
VANECK VECTORS ETF TR PUT 92189F953 286 2,000 SH Put DFND   0 0 2,000
VANECK VECTORS ETF TR RUSSIA ETF 92189F403 3,090 116,050 SH   DFND   0 0 116,050
VANGUARD INDEX FDS PUT 922908953 411 3,000 SH Put DFND   0 0 3,000
VANGUARD INDEX FDS S&P 500 ETF SHS 922908363 502,670 1,148,252 SH   DFND   0 0 1,148,252
VANGUARD INDEX FDS REAL ESTATE ETF 922908553 2,593 22,350 SH   DFND   0 0 22,350
VANGUARD INTL EQUITY INDEX F FTSE EUROPE ETF 922042874 86,772 1,271,570 SH   DFND   1,271,570 0 0
VANGUARD INTL EQUITY INDEX F TT WRLD ST ETF 922042742 15,974 148,288 SH   DFND   0 0 148,288
VARONIS SYS INC COM 922280102 48 952 SH   DFND   0 0 952
VELODYNE LIDAR INC COM 92259F101 44 9,113 SH   DFND   0 0 9,113
VERACYTE INC COM 92337F107 17 402 SH   DFND   0 0 402
VERTEX PHARMACEUTICALS INC COM 92532F100 203 914 SH   DFND   0 0 914
VIEW INC COM CL A 92671V106 43 10,596 SH   DFND   0 0 10,596
VIRGIN GALACTIC HOLDINGS INC COM 92766K106 43 3,086 SH   DFND   0 0 3,086
VISA INC COM CL A 92826C839 243 1,116 SH   DFND   0 0 1,116
VMWARE INC CL A COM 928563402 104 886 SH   DFND   0 0 886
VORNADO RLTY TR SH BEN INT 929042109 14 324 SH   DFND   0 0 324
VUZIX CORP COM NEW 92921W300 42 4,824 SH   DFND   0 0 4,824
WABTEC CORP COM 929740108 41 443 SH   DFND   0 0 443
WALMART INC COM 931142103 5,221 36,469 SH   DFND   0 0 36,469
WASTE MGMT INC DEL COM 94106L109 141 850 SH   DFND   0 0 850
WATERS CORP COM 941848103 83 222 SH   DFND   0 0 222
WELLS FARGO CO NEW COM 949746101 6,824 141,868 SH   DFND   0 0 141,868
WESTERN DIGITAL CORP COM 958102105 77 1,176 SH   DFND   0 0 1,176
WESTLAKE CHEM CORP COM 960413102 159 1,637 SH   DFND   0 0 1,637
WESTPORT FUEL SYSTEMS INC COM NEW 960908309 138 58,707 SH   DFND   0 0 58,707
WESTROCK CO COM 96145D105 25 557 SH   DFND   0 0 557
WEYERHAEUSER CO COM 962166104 72 1,768 SH   DFND   0 0 1,768
WISDOMTREE TR INDIA ERNGS FD 97717W422 1,278 35,000 SH   DFND   0 0 35,000
WOLFSPEED INC COM 977852102 64 582 SH   DFND   0 0 582
WORKHORSE GROUP INC COM NEW 98138J206 41 9,096 SH   DFND   0 0 9,096
WORTHINGTON INDS INC COM 981811102 153 2,829 SH   DFND   0 0 2,829
XP INC CL A G98239109 31,517 1,109,119 SH   DFND   46,985 0 1,062,134
XPERI HOLDING CORP COM 98390M103 48 2,506 SH   DFND   0 0 2,506
XYLEM INC COM 98419M100 35 294 SH   DFND   0 0 294
YELP INC CL A 985817105 49 1,345 SH   DFND   0 0 1,345
YPF SOCIEDAD ANONIMA SPON ADR CL D 984245100 2,657 695,453 SH   DFND   0 0 695,453
ZIMMER BIOMET HLDGS INC COM 98956P102 76 595 SH   DFND   0 0 595
ZOETIS INC CL A 98978V103 154 629 SH   DFND   0 0 629
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 708 3,844 SH   DFND   3,746 0 98
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 322 11,400 SH   DFND   0 0 11,400