The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107 2 93 SH   SOLE   93 0 0
AADI BIOSCIENCE INC COM 00032Q104 4,744 196,408 SH   SOLE   196,408 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 42 1,765 SH   SOLE   1,765 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 156 10,785 SH   SOLE   10,785 0 0
ADICET BIO INC COM 007002108 3,498 200,000 SH Call SOLE   200,000 0 0
ADICET BIO INC COM 007002108 8,350 477,418 SH   SOLE   477,418 0 0
AGENUS INC COM NEW 00847G705 332 103,192 SH   SOLE   103,192 0 0
AILERON THERAPEUTICS INC COM 00887A105 1,556 2,763,583 SH   SOLE   2,763,583 0 0
ALLAKOS INC COM 01671P100 2,135 218,000 SH Call SOLE   218,000 0 0
ALLAKOS INC COM 01671P100 366 37,400 SH Put SOLE   37,400 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 204 1,195 SH   SOLE   1,195 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 30,237 178,300 SH Call SOLE   178,300 0 0
ALTAMIRA THERAPEUTICS LTD SHS G0360L100 553 304,791 SH   SOLE   304,791 0 0
AMICUS THERAPEUTICS INC COM 03152W109 1,896 164,174 SH   SOLE   164,174 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 72 34,131 SH   SOLE   34,131 0 0
ANEBULO PHARMACEUTICALS INC COM 034569103 1,071 172,309 SH   SOLE   172,309 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 9,455 200,000 SH Call SOLE   200,000 0 0
APPLIED GENETIC TECHNOLOGIES COM 03820J100 742 390,394 SH   SOLE   390,394 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 138 102,089 SH   SOLE   102,089 0 0
ARCUS BIOSCIENCES INC COM 03969F109 5,044 124,600 SH Put SOLE   124,600 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 2,072 22,300 SH Call SOLE   22,300 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 200 2,161 SH   SOLE   2,161 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 1,130 8,400 SH   SOLE   8,400 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 187 917,348 SH   SOLE   917,348 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 501 214,861 SH   SOLE   214,861 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 473 87,580 SH   SOLE   87,580 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 1,043 116,600 SH Call SOLE   116,600 0 0
ATHENEX INC COM 04685N103 103 76,139 SH   SOLE   76,139 0 0
ATHIRA PHARMA INC COM 04746L104 11,207 860,000 SH Call SOLE   860,000 0 0
ATYR PHARMA INC COM NEW 002120202 262 35,048 SH   SOLE   35,048 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 1,883 82,335 SH   SOLE   82,335 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 2,827 544,819 SH   SOLE   544,819 0 0
AVALO THERAPEUTICS INC COM 05338F108 1,223 718,705 SH   SOLE   718,705 0 0
AYALA PHARMACEUTICALS INC COM 05465V108 5,696 669,271 SH   SOLE   669,271 0 0
BAUDAX BIO INC COM 07160F107 21 95,059 SH   SOLE   95,059 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 728 73,789 SH   SOLE   73,789 0 0
BELLICUM PHARMACEUTICALS INC COM NEW 079481404 739 496,756 SH   SOLE   496,756 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 402 50,000 SH   SOLE   50,000 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 37,321 613,126 SH   SOLE   613,126 0 0
BIOGEN INC COM 09062X103 7,087 29,533 SH   SOLE   29,533 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,836 100,000 SH Call SOLE   100,000 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 104 5,167 SH   SOLE   5,167 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 801 150,484 SH   SOLE   150,484 0 0
BLUEBIRD BIO INC COM 09609G100 2 287 SH   SOLE   287 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 1,159 289,550 SH   SOLE   289,550 0 0
BRIDGEBIO PHARMA INC COM 10806X102 25 1,500 SH   SOLE   1,500 0 0
BRIDGEBIO PHARMA INC COM 10806X102 15,173 909,700 SH Put SOLE   909,700 0 0
BRIDGEBIO PHARMA INC COM 10806X102 1,668 100,000 SH Call SOLE   100,000 0 0
BRIGHT MINDS BIOSCIENCES INC COM 10919W108 317 100,000 SH   SOLE   100,000 0 0
CABALETTA BIO INC COM 12674W109 3,678 970,398 SH   SOLE   970,398 0 0
CABALETTA BIO INC COM 12674W109 1,603 423,000 SH Call SOLE   423,000 0 0
CASI PHARMACEUTICALS INC COM 14757U109 978 1,223,067 SH   SOLE   1,223,067 0 0
CATALYST BIOSCIENCES INC COM NEW 14888D208 416 454,346 SH   SOLE   454,346 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 17,433 451,200 SH Put SOLE   451,200 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 16,198 419,216 SH   SOLE   419,216 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 22,946 593,800 SH Call SOLE   593,800 0 0
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104 1,829 265,264 SH   SOLE   265,264 0 0
CHIMERIX INC COM 16934W106 5,114 795,410 SH   SOLE   795,410 0 0
CLENE INC COMMON STOCK 185634102 2,006 489,321 SH   SOLE   489,321 0 0
CLOVIS ONCOLOGY INC COM 189464100 3,016 1,112,669 SH   SOLE   1,112,669 0 0
CODIAK BIOSCIENCES INC COM 192010106 554 49,680 SH   SOLE   49,680 0 0
COMPASS THERAPEUTICS INC COM 20454B104 222 70,000 SH   SOLE   70,000 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 1,350 262,237 SH   SOLE   262,237 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 584 948,526 SH   SOLE   948,526 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 1,163 482,610 SH   SOLE   482,610 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 385 99,422 SH   SOLE   99,422 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 866 502,627 SH   SOLE   502,627 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 1,078 310,110 SH   SOLE   310,110 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 291 29,800 SH Call SOLE   29,800 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 8 800 SH Put SOLE   800 0 0
DIAMEDICA THERAPEUTICS INC COM NEW 25253X207 779 209,082 SH   SOLE   209,082 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 1,519 344,578 SH   SOLE   344,578 0 0
ENVERIC BIOSCIENCES INC COM NEW 29405E109 372 400,000 SH   SOLE   400,000 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 262 21,427 SH   SOLE   21,427 0 0
FATE THERAPEUTICS INC COM 31189P102 528 9,038 SH   SOLE   9,038 0 0
FINCH THERAPEUTICS GROUP INC COM 31773D101 3,148 315,732 SH   SOLE   315,732 0 0
FRAZIER LIFESCIENCES ACQU CO UNIT 12/09/2025 G3710A121 9 941 SH   SOLE   941 0 0
GALAPAGOS NV SPON ADR 36315X101 4,861 86,865 SH   SOLE   86,865 0 0
GAMIDA CELL LTD SHS M47364100 79 31,029 SH   SOLE   31,029 0 0
GEMINI THERAPEUTICS INC COM 36870G105 1,225 421,050 SH   SOLE   421,050 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 228 196,821 SH   SOLE   196,821 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 4,803 164,082 SH   SOLE   164,082 0 0
GOSSAMER BIO INC COM 38341P102 2,262 200,000 SH Call SOLE   200,000 0 0
GOSSAMER BIO INC COM 38341P102 13,199 1,166,933 SH   SOLE   1,166,933 0 0
HARPOON THERAPEUTICS INC COM 41358P106 840 111,292 SH   SOLE   111,292 0 0
HEPION PHARMACEUTICALS INC COM 426897104 630 553,273 SH   SOLE   553,273 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 8,153 75,661 SH   SOLE   75,661 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 26,607 246,900 SH Call SOLE   246,900 0 0
IGM BIOSCIENCES INC COM 449585108 44 1,500 SH   SOLE   1,500 0 0
IMMATICS N.V SHS N44445109 9,913 737,546 SH   SOLE   737,546 0 0
IMMUNOPRECISE ANTIBODIES LTD COM NEW 45257F200 395 73,882 SH   SOLE   73,882 0 0
INFLARX NV COM N44821101 1,577 331,048 SH   SOLE   331,048 0 0
INHIBRX INC COM 45720L107 3,529 80,800 SH Call SOLE   80,800 0 0
INHIBRX INC COM 45720L107 6,542 149,850 SH   SOLE   149,850 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 18 1,100 SH Put SOLE   1,100 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 562 34,565 SH   SOLE   34,565 0 0
INVENTIVA SA ADS 46124U107 197 14,748 SH   SOLE   14,748 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 3,294 172,521 SH   SOLE   172,521 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 3,742 196,000 SH Put SOLE   196,000 0 0
ISHARES TR ISHARES BIOTECH 464287556 3,666 24,022 SH   SOLE   24,022 0 0
IVERIC BIO INC COM 46583P102 778 46,519 SH   SOLE   46,519 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 484 36,576 SH   SOLE   36,576 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 5 785 SH   SOLE   785 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 17,069 1,020,917 SH   SOLE   1,020,917 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 2,830 169,300 SH Call SOLE   169,300 0 0
KINNATE BIOPHARMA INC COM 49705R105 35 1,990 SH   SOLE   1,990 0 0
KODIAK SCIENCES INC COM 50015M109 14,235 167,900 SH Call SOLE   167,900 0 0
LARIMAR THERAPEUTICS INC COM 517125100 510 47,193 SH   SOLE   47,193 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 1,583 325,445 SH   SOLE   325,445 0 0
LYRA THERAPEUTICS INC COM 55234L105 1,719 394,536 SH   SOLE   394,536 0 0
MACROGENICS INC COM 556099109 2,506 156,047 SH   SOLE   156,047 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 2,008 23,700 SH   SOLE   23,700 0 0
MAXCYTE INC COM 57777K106 1,325 130,000 SH   SOLE   130,000 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 307 853,680 SH   SOLE   853,680 0 0
MERUS N V COM N5749R100 1,619 50,907 SH   SOLE   50,907 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 11,464 1,750,043 SH   SOLE   1,750,043 0 0
MIND MEDICINE MINDMED INC COM SUB VTG 60255C109 138 100,000 SH   SOLE   100,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 191 1,300 SH Put SOLE   1,300 0 0
MUSTANG BIO INC COM 62818Q104 840 506,033 SH   SOLE   506,033 0 0
MYMD PHARMACEUTICALS INC COM 62856X102 751 124,000 SH   SOLE   124,000 0 0
NEKTAR THERAPEUTICS COM 640268108 3,378 250,000 SH Call SOLE   250,000 0 0
NEXTCURE INC COM 65343E108 804 134,055 SH   SOLE   134,055 0 0
NOVAVAX INC COM NEW 670002401 183 1,283 SH   SOLE   1,283 0 0
NUVATION BIO INC COM CL A 67080N101 1,700 200,000 SH   SOLE   200,000 0 0
OCULAR THERAPEUTIX INC COM 67576A100 191 27,551 SH   SOLE   27,551 0 0
OCUPHIRE PHARMA INC COM 67577R102 442 118,063 SH   SOLE   118,063 0 0
ODONATE THERAPEUTICS INC COM 676079106 1,810 1,340,631 SH   SOLE   1,340,631 0 0
ONCONOVA THERAPEUTICS INC COM NEW 68232V801 37 15,063 SH   SOLE   15,063 0 0
ONCTERNAL THERAPEUTICS INC COM 68236P107 451 199,180 SH   SOLE   199,180 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 195 148,131 SH   SOLE   148,131 0 0
OTONOMY INC COM 68906L105 433 208,306 SH   SOLE   208,306 0 0
OVID THERAPEUTICS INC COM 690469101 2,264 705,082 SH   SOLE   705,082 0 0
PANBELA THERAPEUTICS INC COM 69833Q100 592 338,382 SH   SOLE   338,382 0 0
PARDES BIOSCIENCES INC COM 69945Q105 6,547 400,000 SH   SOLE   400,000 0 0
PASSAGE BIO INC COM 702712100 431 67,849 SH   SOLE   67,849 0 0
PDS BIOTECHNOLOGY CORP COM 70465T107 28 3,495 SH   SOLE   3,495 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 1,467 74,560 SH   SOLE   74,560 0 0
PLIANT THERAPEUTICS INC COM 729139105 1,170 86,712 SH   SOLE   86,712 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 4,341 126,900 SH Call SOLE   126,900 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 1,885 279,256 SH   SOLE   279,256 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 152 49,843 SH   SOLE   49,843 0 0
QUANTUM SI INC COM CL A 74765K105 1,136 144,406 SH   SOLE   144,406 0 0
RAFAEL HLDGS INC COM CL B 75062E106 370 72,515 SH   SOLE   72,515 0 0
RAFAEL HLDGS INC COM CL B 75062E106 510 100,000 SH Put SOLE   100,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 2,637 100,000 SH Put SOLE   100,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 5,274 200,000 SH Call SOLE   200,000 0 0
REGULUS THERAPEUTICS INC COM NEW 75915K200 388 1,228,416 SH   SOLE   1,228,416 0 0
RELMADA THERAPEUTICS INC COM 75955J402 467 20,743 SH   SOLE   20,743 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 1,497 175,000 SH   SOLE   175,000 0 0
RENOVACOR INC COM 75989E106 2,641 342,902 SH   SOLE   342,902 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 1,164 439,356 SH   SOLE   439,356 0 0
SAGE THERAPEUTICS INC COM 78667J108 192 4,500 SH Call SOLE   4,500 0 0
SAREPTA THERAPEUTICS INC COM 803607100 35,962 399,400 SH Call SOLE   399,400 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 2,831 629,384 SH   SOLE   629,384 0 0
SAVARA INC COM 805111101 1,910 1,539,691 SH   SOLE   1,539,691 0 0
SCPHARMACEUTICALS INC COM 810648105 4,525 901,362 SH   SOLE   901,362 0 0
SEELOS THERAPEUTICS INC COM 81577F109 398 244,171 SH   SOLE   244,171 0 0
SERES THERAPEUTICS INC COM 81750R102 6,630 795,903 SH   SOLE   795,903 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 12,370 569,029 SH   SOLE   569,029 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 50 121,694 SH   SOLE   121,694 0 0
SOLID BIOSCIENCES INC COM 83422E105 911 521,155 SH   SOLE   521,155 0 0
SPDR SER TR S&P BIOTECH 78464A870 10,345 92,400 SH Call SOLE   92,400 0 0
SPDR SER TR S&P BIOTECH 78464A870 60,727 542,400 SH Put SOLE   542,400 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 397 478,561 SH   SOLE   478,561 0 0
SYNAPTOGENIX INC COM NEW 87167T201 1,239 145,629 SH   SOLE   145,629 0 0
SYNLOGIC INC COM 87166L100 1,171 483,818 SH   SOLE   483,818 0 0
TANGO THERAPEUTICS INC COM 87583X109 56 5,180 SH   SOLE   5,180 0 0
TEMPEST THERAPEUTICS INC COM 87978U108 310 58,803 SH   SOLE   58,803 0 0
TENAX THERAPEUTICS INC COM NEW 88032L209 722 694,195 SH   SOLE   694,195 0 0
TG THERAPEUTICS INC COM 88322Q108 1,914 100,739 SH   SOLE   100,739 0 0
TG THERAPEUTICS INC COM 88322Q108 1,873 98,600 SH Put SOLE   98,600 0 0
TRACON PHARMACEUTICALS INC COM NEW 89237H209 7,454 2,691,110 SH   SOLE   2,691,110 0 0
VALLON PHARMACEUTICALS INC COM 92023M101 1,184 198,085 SH   SOLE   198,085 0 0
VASCULAR BIOGENICS LTD COM M96883109 1,558 790,838 SH   SOLE   790,838 0 0
VAXCYTE INC COM 92243G108 7,021 295,111 SH   SOLE   295,111 0 0
VERASTEM INC COM 92337C104 1,308 637,371 SH   SOLE   637,371 0 0
VIKING THERAPEUTICS INC COM 92686J106 2,303 500,642 SH   SOLE   500,642 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 927 475,693 SH   SOLE   475,693 0 0
VTV THERAPEUTICS INC CL A 918385105 697 700,000 SH   SOLE   700,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 3,119 993,481 SH   SOLE   993,481 0 0
X4 PHARMACEUTICALS INC COM 98420X103 5,186 2,264,491 SH   SOLE   2,264,491 0 0
XENON PHARMACEUTICALS INC COM 98420N105 5,597 179,138 SH   SOLE   179,138 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 678 228,761 SH   SOLE   228,761 0 0
ZAI LAB LTD ADR 98887Q104 603 9,600 SH Call SOLE   9,600 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 16,067 191,140 SH   SOLE   191,140 0 0
ZOGENIX INC COM NEW 98978L204 9,594 590,400 SH Call SOLE   590,400 0 0