The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADICET BIO INC COM 007002108 1,098 140,000 SH   DFND 1,2,3,4 140,000 0 0
ALLIANCE DATA SYSTEMS CORP COM 018581108 13,116 130,000 SH   DFND 1,2,3,4 130,000 0 0
AMAZON COM INC COM 023135106 14,885 4,531 SH   DFND 1,2,3,4 4,531 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 1,648 50,000 SH Put DFND 1,2,3,4 50,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 3,296 100,000 SH   DFND 1,2,3,4 100,000 0 0
API GROUP CORP COM STK 00187Y100 27,730 1,362,656 SH   DFND 1,2,3,4 1,362,656 0 0
ATHENE HOLDING LTD CL A G0684D107 11,489 166,825 SH   DFND 1,2,3,4 166,825 0 0
AVERY DENNISON CORP COM 053611109 16,504 79,650 SH   DFND 1,2,3,4 79,650 0 0
BEYOND AIR INC COM 08862L103 8,676 780,228 SH   DFND 1,2,3,4 780,228 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 50,754 365,373 SH   DFND 1,2,3,4 365,373 0 0
CARA THERAPEUTICS INC COM 140755109 11,057 715,684 SH   DFND 1,2,3,4 715,684 0 0
CURIS INC COM NEW 231269200 10,016 1,279,220 SH   DFND 1,2,3,4 1,279,220 0 0
DISNEY WALT CO COM 254687106 17,915 105,900 SH   DFND 1,2,3,4 105,900 0 0
DUCKHORN PORTFOLIO INC COM 26414D106 2,678 117,000 SH   DFND 1,2,3,4 117,000 0 0
EDITAS MEDICINE INC COM 28106W103 4,108 100,000 SH Put DFND 1,2,3,4 100,000 0 0
EQUITABLE HLDGS INC COM 29452E101 9,900 334,000 SH   DFND 1,2,3,4 334,000 0 0
EUCRATES BIOMEDICAL ACQU COR *W EXP 10/23/202 G3141W122 48 66,665 SH   DFND 1,2,3,4 66,665 0 0
EUCRATES BIOMEDICAL ACQU COR SHS G3141W106 1,956 200,000 SH   DFND 1,2,3,4 200,000 0 0
EXICURE INC COM 30205M101 407 339,395 SH   DFND 1,2,3,4 339,395 0 0
FACEBOOK INC CL A 30303M102 41,937 123,567 SH   DFND 1,2,3,4 123,567 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 7,988 65,650 SH   DFND 1,2,3,4 65,650 0 0
FIVERR INTL LTD ORD SHS M4R82T106 1,827 10,000 SH Put DFND 1,2,3,4 10,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107 2,866 205,741 SH   DFND 1,2,3,4 205,741 0 0
GENERAC HLDGS INC COM 368736104 12,260 30,000 SH   DFND 1,2,3,4 30,000 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 3,786 1,972,056 SH   DFND 1,2,3,4 1,972,056 0 0
GINKGO BIOWORKS HOLDINGS INC CL A SHS 37611X100 869 75,000 SH   DFND 1,2,3,4 75,000 0 0
GREAT ELM GROUP INC COM NEW 39037G109 2,820 1,259,049 SH   DFND 1,2,3,4 1,259,049 0 0
GS ACQUISITION HLDGS CORP II COM CL A 36258Q105 6,725 658,000 SH   DFND 1,2,3,4 658,000 0 0
GTY TECHNOLOGY HOLDINGS INC COM 362409104 8,720 1,159,600 SH   DFND 1,2,3,4 1,159,600 0 0
HAEMONETICS CORP MASS COM 405024100 7,059 100,000 SH   DFND 1,2,3,4 100,000 0 0
HAEMONETICS CORP MASS COM 405024100 7,059 100,000 SH Put DFND 1,2,3,4 100,000 0 0
HUMANA INC COM 444859102 13,153 33,800 SH   DFND 1,2,3,4 33,800 0 0
IMAGO BIOSCIENCES INC COM 45250K107 3,482 173,830 SH   DFND 1,2,3,4 173,830 0 0
INFLARX NV COM N44821101 1,036 400,000 SH   DFND 1,2,3,4 400,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 95,156 435,000 SH Put DFND 1,2,3,4 435,000 0 0
LITHIA MTRS INC COM 536797103 24,858 78,408 SH   DFND 1,2,3,4 78,408 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 22 33,332 SH   DFND 1,2,3,4 33,332 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 2,925 300,000 SH   DFND 1,2,3,4 300,000 0 0
MICROSOFT CORP COM 594918104 10,180 36,109 SH   DFND 1,2,3,4 36,109 0 0
MOLECULAR TEMPLATES INC COM 608550109 6,853 1,021,317 SH   DFND 1,2,3,4 1,021,317 0 0
NEXIMMUNE INC COM 65344D109 1,786 117,962 SH   DFND 1,2,3,4 117,962 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 2,472 47,800 SH Put DFND 1,2,3,4 47,800 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 12,591 243,450 SH   DFND 1,2,3,4 243,450 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 7,664 414,489 SH   DFND 1,2,3,4 414,489 0 0
RAPT THERAPEUTICS INC COM 75382E109 35,655 1,148,321 SH   DFND 1,2,3,4 1,148,321 0 0
ROPER TECHNOLOGIES INC COM 776696106 9,213 20,650 SH   DFND 1,2,3,4 20,650 0 0
SCYNEXIS INC COM NEW 811292200 3,376 637,048 SH   DFND 1,2,3,4 637,048 0 0
SEA LTD SPONSORD ADS 81141R100 9,881 31,000 SH   DFND 1,2,3,4 31,000 0 0
SHIFT4 PMTS INC CL A 82452J109 18,013 232,370 SH   DFND 1,2,3,4 232,370 0 0
SIGNATURE BK NEW YORK N Y COM 82669G104 15,180 55,750 SH   DFND 1,2,3,4 55,750 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 8,328 832,800 SH   DFND 1,2,3,4 832,800 0 0
SOVOS BRANDS INC COM 84612U107 7,045 505,000 SH   DFND 1,2,3,4 505,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 115,868 270,000 SH Put DFND 1,2,3,4 270,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 23,256 185,000 SH Put DFND 1,2,3,4 185,000 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 13,251 111,000 SH   DFND 1,2,3,4 111,000 0 0
TECK RESOURCES LTD CL B 878742204 15,191 609,850 SH   DFND 1,2,3,4 609,850 0 0
TRILOGY METALS INC NEW COM 89621C105 3,096 1,673,461 SH   DFND 1,2,3,4 1,673,461 0 0
TWILIO INC CL A 90138F102 10,635 33,334 SH   DFND 1,2,3,4 33,334 0 0
UNDER ARMOUR INC CL A 904311107 20,180 1,000,000 SH   DFND 1,2,3,4 1,000,000 0 0
VINCERX PHARMA INC COM NEW 92731L106 4,930 304,896 SH   DFND 1,2,3,4 304,896 0 0
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 12,233 385,670 SH   DFND 1,2,3,4 385,670 0 0
WNS HLDGS LTD SPON ADR 92932M101 3,272 40,000 SH   DFND 1,2,3,4 40,000 0 0