The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 720 3,676 SH   SOLE   3,676 0 0
3M CO COM 88579Y101 37,640 189,497 SH   SOLE   189,497 0 0
89BIO INC COM 282559103 6,984 373,473 SH   SOLE   373,473 0 0
ABBOTT LABS COM 002824100 76,575 660,529 SH   SOLE   660,529 0 0
ABBOTT LABS COM 002824100 2 15 SH   OTR 1 0 0 15
ABBVIE INC COM 00287Y109 1 13 SH   OTR 1 0 0 13
ABBVIE INC COM 00287Y109 39,632 351,843 SH   SOLE   351,843 0 0
ABIOMED INC COM 003654100 238 764 SH   SOLE   764 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 6,721 275,560 SH   SOLE   275,560 0 0
ACCELERON PHARMA INC COM 00434H108 3 20 SH   OTR 1 0 0 20
ACCELERON PHARMA INC COM 00434H108 69,902 557,035 SH   SOLE   557,035 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 1 4 SH   OTR 1 0 0 4
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 0 12 SH   OTR 1 0 0 12
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 1,582 161,612 SH   SOLE   161,612 0 0
ACTIVISION BLIZZARD INC COM 00507V109 29,914 313,429 SH   SOLE   313,429 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 121,813 208,000 SH   SOLE   208,000 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 2 4 SH   OTR 1 0 0 4
ADVANCED DRAIN SYS INC DEL COM 00790R104 42,414 363,850 SH   SOLE   363,850 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 4 38 SH   OTR 1 0 0 38
ADVANCED MICRO DEVICES INC COM 007903107 80,803 860,243 SH   SOLE   860,243 0 0
ADVANCED MICRO DEVICES INC COM 007903107 2 18 SH   OTR 1 0 0 18
AFLAC INC COM 001055102 3,173 59,131 SH   SOLE   59,131 0 0
AFLAC INC COM 001055102 4 74 SH   OTR 1 0 0 74
AGILE THERAPEUTICS INC COM 00847L100 39 29,000 SH   SOLE   29,000 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 7 46 SH   OTR 1 0 0 46
AGILENT TECHNOLOGIES INC COM 00846U101 91,063 616,082 SH   SOLE   616,082 0 0
AGNICO EAGLE MINES LTD COM 008474108 483 7,982 SH   SOLE   7,982 0 0
AILERON THERAPEUTICS INC COM 00887A105 28 22,556 SH   SOLE   22,556 0 0
AIR PRODS & CHEMS INC COM 009158106 71,625 248,973 SH   SOLE   248,973 0 0
AIR PRODS & CHEMS INC COM 009158106 5 19 SH   OTR 1 0 0 19
AIRBNB INC COM CL A 009066101 4,557 29,759 SH   SOLE   29,759 0 0
AKAMAI TECHNOLOGIES INC COM 00971T101 1,957 16,784 SH   SOLE   16,784 0 0
AKAMAI TECHNOLOGIES INC NOTE 0.125% 5/0 00971TAJ0 1,312 1,000 PRN   SOLE   1,000 0 0
AKAMAI TECHNOLOGIES INC NOTE 0.375% 9/0 00971TAL5 1,860 1,600 PRN   SOLE   1,600 0 0
AKERO THERAPEUTICS INC COM 00973Y108 3,143 126,667 SH   SOLE   126,667 0 0
ALBEMARLE CORP COM 012653101 1,144 6,789 SH   SOLE   6,789 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 1,586 140,000 SH   SOLE   140,000 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 1,763 9,691 SH   SOLE   9,691 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 92,500 503,510 SH   SOLE   503,510 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 107,966 476,086 SH   SOLE   476,086 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 2 7 SH   OTR 1 0 0 7
ALIGN TECHNOLOGY INC COM 016255101 18,052 29,545 SH   SOLE   29,545 0 0
ALLAKOS INC COM 01671P100 5,639 66,054 SH   SOLE   66,054 0 0
ALLAKOS INC COM 01671P100 1,566 1,400 PRN   SOLE   1,400 0 0
ALLEGHANY CORP MD COM 017175100 3,501 3,750 PRN   SOLE   3,750 0 0
ALLEGHANY CORP MD COM 017175100 16,731 25,082 SH   SOLE   25,082 0 0
ALLSTATE CORP COM 020002101 2 15 SH   OTR 1 0 0 15
ALLSTATE CORP COM 020002101 4,370 33,501 SH   SOLE   33,501 0 0
ALLY FINL INC COM 02005N100 16,611 333,287 SH   SOLE   333,287 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 29,636 174,822 SH   SOLE   174,822 0 0
ALPHABET INC CAP STK CL A 02079K305 442,738 181,317 SH   SOLE   181,317 0 0
ALPHABET INC CAP STK CL A 02079K305 17 7 SH   OTR 1 0 0 7
ALPHABET INC CAP STK CL C 02079K107 116,231 46,375 SH   SOLE   46,375 0 0
ALTERYX INC COM CL A 02156B103 2,230 25,923 SH   SOLE   25,923 0 0
AMAZON COM INC COM 023135106 143,709 41,774 SH   SOLE   41,774 0 0
AMBARELLA INC SHS G037AX101 21,033 197,248 SH   SOLE   197,248 0 0
AMERESCO INC CL A 02361E108 3 42 SH   OTR 1 0 0 42
AMERESCO INC CL A 02361E108 23,047 367,464 SH   SOLE   367,464 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 276 13,000 SH   SOLE   13,000 0 0
AMERICAN EAGLE OUTFITTERS IN COM 02553E106 7,103 189,260 SH   SOLE   189,260 0 0
AMERICAN EXPRESS CO COM 025816109 8,710 52,714 SH   SOLE   52,714 0 0
AMERICAN EXPRESS CO COM 025816109 2 15 SH   OTR 1 0 0 15
AMERICAN INTL GROUP INC COM NEW 026874784 2,941 61,788 SH   SOLE   61,788 0 0
AMERICAN TOWER CORP NEW COM 03027X100 10,000 37,018 SH   SOLE   37,018 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 60,101 389,940 SH   SOLE   389,940 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 4 29 SH   OTR 1 0 0 29
AMERIPRISE FINL INC COM 03076C106 2 10 SH   OTR 1 0 0 10
AMERIPRISE FINL INC COM 03076C106 3,652 14,672 SH   SOLE   14,672 0 0
AMERISOURCEBERGEN CORP COM 03073E105 1,362 11,895 SH   SOLE   11,895 0 0
AMETEK INC COM 031100100 3,266 24,462 SH   SOLE   24,462 0 0
AMGEN INC COM 031162100 234,883 963,624 SH   SOLE   963,624 0 0
AMGEN INC COM 031162100 8 33 SH   OTR 1 0 0 33
AMPHENOL CORP NEW CL A 032095101 2,830 41,369 SH   SOLE   41,369 0 0
ANALOG DEVICES INC COM 032654105 45,096 261,941 SH   SOLE   261,941 0 0
ANDERSONS INC COM 034164103 213 6,973 SH   SOLE   6,973 0 0
ANNALY CAPITAL MANAGEMENT IN COM 035710409 1,010 113,705 SH   SOLE   113,705 0 0
ANSYS INC COM 03662Q105 2 6 SH   OTR 1 0 0 6
ANSYS INC COM 03662Q105 53,643 154,565 SH   SOLE   154,565 0 0
ANTHEM INC COM 036752103 21,705 56,848 SH   SOLE   56,848 0 0
ANTHEM INC COM 036752103 1 3 SH   OTR 1 0 0 3
APELLIS PHARMACEUTICALS INC COM 03753U106 20,054 317,315 SH   SOLE   317,315 0 0
APOLLO GLOBAL MGMT INC COM CL A 03768E105 762 12,250 SH   SOLE   12,250 0 0
APPLE INC COM 037833100 22 160 SH   OTR 1 0 0 160
APPLE INC COM 037833100 470,248 3,433,467 SH   SOLE   3,433,467 0 0
APPLIED MATLS INC COM 038222105 91,380 641,716 SH   SOLE   641,716 0 0
APPLIED MATLS INC COM 038222105 2 11 SH   OTR 1 0 0 11
APTIV PLC SHS G6095L109 5 31 SH   OTR 1 0 0 31
ARCH CAP GROUP LTD ORD G0450A105 881 22,622 SH   SOLE   22,622 0 0
ARCHER DANIELS MIDLAND CO COM 039483102 1 18 SH   OTR 1 0 0 18
ARCHER DANIELS MIDLAND CO COM 039483102 1,533 25,290 SH   SOLE   25,290 0 0
ARDELYX INC COM 039697107 6,453 851,291 SH   SOLE   851,291 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 42,715 626,318 SH   SOLE   626,318 0 0
ARGENX SE SPONSORED ADR 04016X101 14,911 49,526 SH   SOLE   49,526 0 0
ARISTA NETWORKS INC COM 040413106 1,133 3,128 SH   SOLE   3,128 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 808 8,740 SH   SOLE   8,740 0 0
ARK ETF TR INNOVATION ETF 00214Q104 923 7,060 SH   SOLE   7,060 0 0
ARROW ELECTRS INC COM 042735100 3 22 SH   OTR 1 0 0 22
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 16,267 196,408 SH   SOLE   196,408 0 0
ARVINAS INC COM 04335A105 19,296 250,593 SH   SOLE   250,593 0 0
ARVINAS INC COM 04335A105 1 10 SH   OTR 1 0 0 10
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 37,226 282,980 SH   SOLE   282,980 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 4,321 1,113,754 SH   SOLE   1,113,754 0 0
ASSURANT INC COM 04621X108 1,700 10,885 SH   SOLE   10,885 0 0
ASSURANT INC COM 04621X108 1 7 SH   OTR 1 0 0 7
ASTRAZENECA PLC SPONSORED ADR 046353108 15 246 SH   OTR 1 0 0 246
ASTRAZENECA PLC SPONSORED ADR 046353108 15,403 257,140 SH   SOLE   257,140 0 0
ASURE SOFTWARE INC COM 04649U102 231 26,000 SH   SOLE   26,000 0 0
AT HOME GROUP INC COM 04650Y100 3,437 93,286 SH   SOLE   93,286 0 0
AT&T INC COM 00206R102 6 213 SH   OTR 1 0 0 213
AT&T INC COM 00206R102 13,923 483,760 SH   SOLE   483,760 0 0
ATHENE HOLDING LTD CL A G0684D107 14,787 219,060 SH   SOLE   219,060 0 0
ATMOS ENERGY CORP COM 049560105 2 21 SH   OTR 1 0 0 21
ATMOS ENERGY CORP COM 049560105 6,845 71,220 SH   SOLE   71,220 0 0
ATRECA INC CL A COM 04965G109 0 25 SH   OTR 1 0 0 25
ATRECA INC CL A COM 04965G109 3,184 373,681 SH   SOLE   373,681 0 0
AUTODESK INC COM 052769106 2 7 SH   OTR 1 0 0 7
AUTODESK INC COM 052769106 64,531 221,072 SH   SOLE   221,072 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 24,982 125,778 SH   SOLE   125,778 0 0
AUTOZONE INC COM 053332102 2,301 1,542 SH   SOLE   1,542 0 0
AVALARA INC COM 05338G106 730 4,510 SH   SOLE   4,510 0 0
AVALONBAY CMNTYS INC COM 053484101 2,641 12,654 SH   SOLE   12,654 0 0
AVANTOR INC COM 05352A100 12,523 352,662 SH   SOLE   352,662 0 0
AVERY DENNISON CORP COM 053611109 6,589 31,341 SH   SOLE   31,341 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 3,953 159,988 SH   SOLE   159,988 0 0
AXSOME THERAPEUTICS INC COM 05464T104 8,001 118,602 SH   SOLE   118,602 0 0
BAIDU INC SPON ADR REP A 056752108 38,861 190,589 SH   SOLE   190,589 0 0
BAKER HUGHES COMPANY CL A 05722G100 1,241 54,262 SH   SOLE   54,262 0 0
BALL CORP COM 058498106 3 40 SH   OTR 1 0 0 40
BALL CORP COM 058498106 34,303 423,394 SH   SOLE   423,394 0 0
BALLARD PWR SYS INC NEW COM 058586108 4,061 224,096 SH   SOLE   224,096 0 0
BANCO BILBAO VIZCAYA ARGENTA SPONSORED ADR 05946K101 2 307 SH   OTR 1 0 0 307
BANCO BRADESCO S A SP ADR PFD NEW 059460303 811 158,010 SH   SOLE   158,010 0 0
BANK MONTREAL QUE COM 063671101 19,355 188,625 SH   SOLE   188,625 0 0
BANK NEW YORK MELLON CORP COM 064058100 3,482 67,965 SH   SOLE   67,965 0 0
BANK NEW YORK MELLON CORP COM 064058100 1 27 SH   OTR 1 0 0 27
BANK NOVA SCOTIA B C COM 064149107 30,224 464,238 SH   SOLE   464,238 0 0
BARRICK GOLD CORP COM 067901108 1,786 86,278 SH   SOLE   86,278 0 0
BAXTER INTL INC COM 071813109 4,162 51,699 SH   SOLE   51,699 0 0
BCE INC COM NEW 05534B760 279 5,644 SH   SOLE   5,644 0 0
BEAM THERAPEUTICS INC COM 07373V105 9,930 77,147 SH   SOLE   77,147 0 0
BECTON DICKINSON & CO COM 075887109 15,592 64,115 SH   SOLE   64,115 0 0
BEIGENE LTD SPONSORED ADR 07725L102 44,817 130,590 SH   SOLE   130,590 0 0
BEIGENE LTD SPONSORED ADR 07725L102 2 5 SH   OTR 1 0 0 5
BERKLEY W R CORP COM 084423102 528 7,092 SH   SOLE   7,092 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 31,430 113,090 SH   SOLE   113,090 0 0
BEST BUY INC COM 086516101 26,325 228,955 SH   SOLE   228,955 0 0
BEST BUY INC COM 086516101 1,068 800 PRN   SOLE   800 0 0
BHP GROUP LTD SPONSORED ADS 088606108 5 75 SH   OTR 1 0 0 75
BHP GROUP PLC SPONSORED ADR 05545E209 1 23 SH   OTR 1 0 0 23
BILIBILI INC SPONS ADS REP Z 090040106 17,539 143,950 SH   SOLE   143,950 0 0
BIO RAD LABS INC CL A 090572207 2 3 SH   OTR 1 0 0 3
BIO RAD LABS INC CL A 090572207 36,889 57,255 SH   SOLE   57,255 0 0
BIOATLA INC COM 09077B104 0 7 SH   OTR 1 0 0 7
BIOATLA INC COM 09077B104 5,492 129,591 SH   SOLE   129,591 0 0
BIOGEN INC COM 09062X103 95,238 275,040 SH   SOLE   275,040 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 4,563 47,005 SH   SOLE   47,005 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,998 107,843 SH   SOLE   107,843 0 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 835 800 PRN   SOLE   800 0 0
BIONTECH SE SPONSORED ADS 09075V102 23,305 104,097 SH   SOLE   104,097 0 0
BIO-TECHNE CORP COM 09073M104 27,605 61,309 SH   SOLE   61,309 0 0
BIO-TECHNE CORP COM 09073M104 2 4 SH   OTR 1 0 0 4
BK OF AMERICA CORP COM 060505104 9 224 SH   OTR 1 0 0 224
BK OF AMERICA CORP COM 060505104 88,056 2,135,715 SH   SOLE   2,135,715 0 0
BLACKBERRY LTD COM 09228F103 183 15,000 SH   SOLE   15,000 0 0
BLACKROCK INC COM 09247X101 9,977 11,403 SH   SOLE   11,403 0 0
BLACKSTONE GROUP INC COM 09260D107 3,303 34,000 SH   SOLE   34,000 0 0
BLINK CHARGING CO COM 09354A100 7,259 176,317 SH   SOLE   176,317 0 0
BLINK CHARGING CO COM 09354A100 1 25 SH   OTR 1 0 0 25
BLOOM ENERGY CORP COM CL A 093712107 15,108 562,250 SH   SOLE   562,250 0 0
BLOOM ENERGY CORP COM CL A 093712107 2 61 SH   OTR 1 0 0 61
BLUEPRINT MEDICINES CORP COM 09627Y109 1 13 SH   OTR 1 0 0 13
BLUEPRINT MEDICINES CORP COM 09627Y109 27,526 312,937 SH   SOLE   312,937 0 0
BOOKING HOLDINGS INC COM 09857L108 49,381 22,568 SH   SOLE   22,568 0 0
BOOKING HOLDINGS INC COM 09857L108 2 1 SH   OTR 1 0 0 1
BOSTON BEER INC CL A 100557107 551 540 SH   SOLE   540 0 0
BOSTON PROPERTIES INC COM 101121101 1,723 15,037 SH   SOLE   15,037 0 0
BOSTON SCIENTIFIC CORP COM 101137107 3,554 83,117 SH   SOLE   83,117 0 0
BP PLC SPONSORED ADR 055622104 1 47 SH   OTR 1 0 0 47
BRIDGEBIO PHARMA INC COM 10806X102 27,754 455,285 SH   SOLE   455,285 0 0
BRINKS CO COM 109696104 1,459 18,982 SH   SOLE   18,982 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 26,687 399,383 SH   SOLE   399,383 0 0
BROADCOM INC COM 11135F101 21,304 44,677 SH   SOLE   44,677 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 849 5,257 SH   SOLE   5,257 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 1,888 36,973 SH   SOLE   36,973 0 0
BROOKFIELD RENEWABLE PARTNER PARTNERSHIP UNIT G16258108 1,421 36,839 SH   SOLE   36,839 0 0
BROWN FORMAN CORP CL B 115637209 1,726 23,032 SH   SOLE   23,032 0 0
BRUKER CORP COM 116794108 4,720 62,128 SH   SOLE   62,128 0 0
BUNGE LIMITED COM G16962105 11,260 144,082 SH   SOLE   144,082 0 0
BURLINGTON STORES INC COM 122017106 1,121 3,483 SH   SOLE   3,483 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 4 28 SH   OTR 1 0 0 28
CADENCE DESIGN SYSTEM INC COM 127387108 24,385 178,224 SH   SOLE   178,224 0 0
CAESARS ENTERTAINMENT INC NE COM 12769G100 1,120 10,795 SH   SOLE   10,795 0 0
CAMPBELL SOUP CO COM 134429109 773 16,950 SH   SOLE   16,950 0 0
CANADIAN IMP BK COMM COM 136069101 1,317 11,560 SH   SOLE   11,560 0 0
CANADIAN NAT RES LTD COM 136385101 699 19,245 SH   SOLE   19,245 0 0
CANADIAN NATL RY CO COM 136375102 4,430 41,938 SH   SOLE   41,938 0 0
CANADIAN PAC RY LTD COM 13645T100 1,354 17,590 SH   SOLE   17,590 0 0
CAPITAL ONE FINL CORP COM 14040H105 6,370 41,178 SH   SOLE   41,178 0 0
CARDINAL HEALTH INC COM 14149Y108 1,549 27,124 SH   SOLE   27,124 0 0
CARDINAL HEALTH INC COM 14149Y108 1 26 SH   OTR 1 0 0 26
CARMAX INC COM 143130102 1,089 8,434 SH   SOLE   8,434 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 1,286 48,790 SH   SOLE   48,790 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 2,760 56,785 SH   SOLE   56,785 0 0
CATALENT INC COM 148806102 4,391 40,616 SH   SOLE   40,616 0 0
CATERPILLAR INC COM 149123101 12,911 59,327 SH   SOLE   59,327 0 0
CBOE GLOBAL MKTS INC COM 12503M108 670 5,631 SH   SOLE   5,631 0 0
CBRE GROUP INC CL A 12504L109 27,379 319,364 SH   SOLE   319,364 0 0
CDW CORP COM 12514G108 3,966 22,706 SH   SOLE   22,706 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 13,365 399,685 SH   SOLE   399,685 0 0
CENTENE CORP DEL COM 15135B101 2,579 35,362 SH   SOLE   35,362 0 0
CENTERPOINT ENERGY INC COM 15189T107 1,567 63,910 SH   SOLE   63,910 0 0
CENTURY BANCORPORATION INC CL A NON VTG 156432106 2,323 20,378 SH   SOLE   20,378 0 0
CERENCE INC COM 156727109 19,272 180,600 SH   SOLE   180,600 0 0
CERIDIAN HCM HLDG INC COM 15677J108 674 7,025 SH   SOLE   7,025 0 0
CERNER CORP COM 156782104 6,158 78,790 SH   SOLE   78,790 0 0
CERNER CORP COM 156782104 2 20 SH   OTR 1 0 0 20
CEVA INC COM 157210105 17,069 360,869 SH   SOLE   360,869 0 0
CF INDS HLDGS INC COM 125269100 597 11,604 SH   SOLE   11,604 0 0
CGI INC CL A SUB VTG 12532H104 3,075 33,879 SH   SOLE   33,879 0 0
CHANGE HEALTHCARE INC COM 15912K100 12,763 553,958 SH   SOLE   553,958 0 0
CHARLES RIV LABS INTL INC COM 159864107 3 9 SH   OTR 1 0 0 9
CHARLES RIV LABS INTL INC COM 159864107 88,092 238,138 SH   SOLE   238,138 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 8,735 12,108 SH   SOLE   12,108 0 0
CHENIERE ENERGY INC COM NEW 16411R208 1,475 17,006 SH   SOLE   17,006 0 0
CHEVRON CORP NEW COM 166764100 3,941 37,628 SH   SOLE   37,628 0 0
CHIASMA INC COM 16706W102 111 23,500 SH   SOLE   23,500 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 12,357 875,124 SH   SOLE   875,124 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 28,740 18,538 SH   SOLE   18,538 0 0
CHUNGHWA TELECOM CO LTD SPON ADR NEW11 17133Q502 386 9,483 SH   SOLE   9,483 0 0
CHURCH & DWIGHT INC COM 171340102 2,759 32,374 SH   SOLE   32,374 0 0
CHURCH & DWIGHT INC COM 171340102 2 19 SH   OTR 1 0 0 19
CI FINL CORP COM 125491100 343 18,696 SH   SOLE   18,696 0 0
CIA ENERGETICA DE MINAS GERA SP ADR N-V PFD 204409601 188 78,834 SH   SOLE   78,834 0 0
CIGNA CORP NEW COM 125523100 8,958 37,786 SH   SOLE   37,786 0 0
CIGNA CORP NEW COM 125523100 2 8 SH   OTR 1 0 0 8
CINCINNATI BELL INC NEW COM NEW 171871502 2,559 165,973 SH   SOLE   165,973 0 0
CINCINNATI FINL CORP COM 172062101 2,233 19,144 SH   SOLE   19,144 0 0
CINTAS CORP COM 172908105 2,784 7,287 SH   SOLE   7,287 0 0
CISCO SYS INC COM 17275R102 1,013 1,000 PRN   SOLE   1,000 0 0
CISCO SYS INC COM 17275R102 37,986 716,709 SH   SOLE   716,709 0 0
CISCO SYS INC COM 17275R102 4 77 SH   OTR 1 0 0 77
CIT GROUP INC COM NEW 125581801 2,887 55,952 SH   SOLE   55,952 0 0
CITIGROUP INC COM NEW 172967424 7 93 SH   OTR 1 0 0 93
CITIGROUP INC COM NEW 172967424 103,587 1,464,121 SH   SOLE   1,464,121 0 0
CITIZENS FINL GROUP INC COM 174610105 12,530 273,158 SH   SOLE   273,158 0 0
CITRIX SYS INC COM 177376100 1,427 12,165 SH   SOLE   12,165 0 0
CLOROX CO DEL COM 189054109 1,039 1,000 PRN   SOLE   1,000 0 0
CLOROX CO DEL COM 189054109 3,450 19,177 SH   SOLE   19,177 0 0
CLOUDERA INC COM 18914U100 12,272 773,774 SH   SOLE   773,774 0 0
CME GROUP INC COM 12572Q105 5,163 24,278 SH   SOLE   24,278 0 0
CNO FINL GROUP INC COM 12621E103 6,784 287,217 SH   SOLE   287,217 0 0
COCA COLA CO COM 191216100 49,867 921,581 SH   SOLE   921,581 0 0
COGENT BIOSCIENCES INC COM 19240Q201 15,495 1,910,601 SH   SOLE   1,910,601 0 0
COGENT BIOSCIENCES INC COM 19240Q201 1 119 SH   OTR 1 0 0 119
COGNEX CORP COM 192422103 799 9,505 SH   SOLE   9,505 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 2,570 37,113 SH   SOLE   37,113 0 0
COHERENT INC COM 192479103 12,097 45,763 SH   SOLE   45,763 0 0
COLGATE PALMOLIVE CO COM 194162103 21,080 259,124 SH   SOLE   259,124 0 0
COLGATE PALMOLIVE CO COM 194162103 2 19 SH   OTR 1 0 0 19
COMCAST CORP NEW CL A 20030N101 40,294 706,673 SH   SOLE   706,673 0 0
COMCAST CORP NEW CL A 20030N101 5 95 SH   OTR 1 0 0 95
COMERICA INC COM 200340107 621 8,711 SH   SOLE   8,711 0 0
CONAGRA BRANDS INC COM 205887102 1,415 38,887 SH   SOLE   38,887 0 0
CONOCOPHILLIPS COM 20825C104 5,986 98,286 SH   SOLE   98,286 0 0
CONSOLIDATED EDISON INC COM 209115104 3,221 44,906 SH   SOLE   44,906 0 0
CONSTELLATION BRANDS INC CL A 21036P108 3,064 13,100 SH   SOLE   13,100 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 9,464 280,008 SH   SOLE   280,008 0 0
CONTINENTAL RES INC COM 212015101 209 5,506 SH   SOLE   5,506 0 0
COPART INC COM 217204106 5,964 45,242 SH   SOLE   45,242 0 0
CORNING INC COM 219350105 3,939 96,308 SH   SOLE   96,308 0 0
CORTEVA INC COM 22052L104 1,093 24,638 SH   SOLE   24,638 0 0
COSTAR GROUP INC COM 22160N109 1,881 22,710 SH   SOLE   22,710 0 0
COSTCO WHSL CORP NEW COM 22160K105 29,279 73,998 SH   SOLE   73,998 0 0
COUPA SOFTWARE INC COM 22266L106 1,425 5,438 SH   SOLE   5,438 0 0
COUPA SOFTWARE INC NOTE 0.375% 6/1 22266LAF3 1,158 1,000 PRN   SOLE   1,000 0 0
CRH PLC ADR 12626K203 3 50 SH   OTR 1 0 0 50
CRH PLC ADR 12626K203 2,635 51,825 SH   SOLE   51,825 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 2,375 9,449 SH   SOLE   9,449 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 19,238 98,606 SH   SOLE   98,606 0 0
CROWN HLDGS INC COM 228368106 2 18 SH   OTR 1 0 0 18
CROWN HLDGS INC COM 228368106 1,811 17,717 SH   SOLE   17,717 0 0
CSX CORP COM 126408103 8,254 257,292 SH   SOLE   257,292 0 0
CSX CORP COM 126408103 2 57 SH   OTR 1 0 0 57
CUMMINS INC COM 231021106 5,388 22,101 SH   SOLE   22,101 0 0
CURIS INC COM NEW 231269200 1 105 SH   OTR 1 0 0 105
CURIS INC COM NEW 231269200 20,014 2,480,058 SH   SOLE   2,480,058 0 0
CVS HEALTH CORP COM 126650100 4 49 SH   OTR 1 0 0 49
CVS HEALTH CORP COM 126650100 27,375 328,083 SH   SOLE   328,083 0 0
CVS HEALTH CORP COM 126650100 537 450 PRN   SOLE   450 0 0
CYTOKINETICS INC COM NEW 23282W605 10,159 513,344 SH   SOLE   513,344 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 14,738 2,328,201 SH   SOLE   2,328,201 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 1 152 SH   OTR 1 0 0 152
D R HORTON INC COM 23331A109 3,590 39,723 SH   SOLE   39,723 0 0
DANAHER CORPORATION COM 235851102 15 56 SH   OTR 1 0 0 56
DANAHER CORPORATION COM 235851102 231,082 861,091 SH   SOLE   861,091 0 0
DARDEN RESTAURANTS INC COM 237194105 1,709 11,703 SH   SOLE   11,703 0 0
DARLING INGREDIENTS INC COM 237266101 2 34 SH   OTR 1 0 0 34
DARLING INGREDIENTS INC COM 237266101 30,813 456,482 SH   SOLE   456,482 0 0
DATADOG INC CL A COM 23804L103 1,245 11,960 SH   SOLE   11,960 0 0
DATADOG INC NOTE 0.125% 6/1 23804LAB9 669 500 PRN   SOLE   500 0 0
DAVITA INC COM 23918K108 7,922 65,777 SH   SOLE   65,777 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 25,923 708,090 SH   SOLE   708,090 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 1 27 SH   OTR 1 0 0 27
DEERE & CO COM 244199105 10,673 30,261 SH   SOLE   30,261 0 0
DELL TECHNOLOGIES INC CL C 24703L202 4,604 46,195 SH   SOLE   46,195 0 0
DENALI THERAPEUTICS INC COM 24823R105 5,003 63,781 SH   SOLE   63,781 0 0
DENTSPLY SIRONA INC COM 24906P109 1,026 16,212 SH   SOLE   16,212 0 0
DEVON ENERGY CORP NEW COM 25179M103 1,856 63,572 SH   SOLE   63,572 0 0
DEXCOM INC COM 252131107 2,365 5,539 SH   SOLE   5,539 0 0
DIAGEO PLC SPON ADR NEW 25243Q205 3 17 SH   OTR 1 0 0 17
DIAGEO PLC SPON ADR NEW 25243Q205 3,456 18,029 SH   SOLE   18,029 0 0
DIAGEO PLC SPON ADR NEW 25243Q205 5,597 5,400 PRN   SOLE   5,400 0 0
DIAMONDBACK ENERGY INC COM 25278X109 634 6,752 SH   SOLE   6,752 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 15,609 418,245 SH   SOLE   418,245 0 0
DIGITAL RLTY TR INC COM 253868103 11,371 75,574 SH   SOLE   75,574 0 0
DIGITAL TURBINE INC COM NEW 25400W102 4,480 58,930 SH   SOLE   58,930 0 0
DISCOVER FINL SVCS COM 254709108 2,973 25,130 SH   SOLE   25,130 0 0
DISCOVERY INC COM SER C 25470F302 852 29,404 SH   SOLE   29,404 0 0
DISH NETWORK CORPORATION CL A 25470M109 515 12,321 SH   SOLE   12,321 0 0
DISNEY WALT CO COM 254687106 88,191 501,740 SH   SOLE   501,740 0 0
DISNEY WALT CO COM 254687106 8 45 SH   OTR 1 0 0 45
DOCUSIGN INC COM 256163106 17,617 63,014 SH   SOLE   63,014 0 0
DOLLAR GEN CORP NEW COM 256677105 9,840 45,475 SH   SOLE   45,475 0 0
DOLLAR TREE INC COM 256746108 1,252 12,578 SH   SOLE   12,578 0 0
DOMINION ENERGY INC COM 25746U109 4,216 57,300 SH   SOLE   57,300 0 0
DOMINION ENERGY INC COM 25746U109 2,332 2,000 PRN   SOLE   2,000 0 0
DOMINOS PIZZA INC COM 25754A201 807 1,731 SH   SOLE   1,731 0 0
DOMTAR CORP COM NEW 257559203 17,367 315,996 SH   SOLE   315,996 0 0
DOVER CORP COM 260003108 2,945 19,556 SH   SOLE   19,556 0 0
DOVER CORP COM 260003108 1 9 SH   OTR 1 0 0 9
DOW INC COM 260557103 5,271 83,300 SH   SOLE   83,300 0 0
DROPBOX INC CL A 26210C104 5,592 184,507 SH   SOLE   184,507 0 0
DUKE REALTY CORP COM NEW 264411505 2,533 53,495 SH   SOLE   53,495 0 0
DUPONT DE NEMOURS INC COM 26614N102 15,735 203,265 SH   SOLE   203,265 0 0
DYNE THERAPEUTICS INC COM 26818M108 6,804 323,393 SH   SOLE   323,393 0 0
EARGO INC COM 270087109 395 9,898 SH   SOLE   9,898 0 0
EATON CORP PLC SHS G29183103 2 16 SH   OTR 1 0 0 16
EBAY INC. COM 278642103 5,300 75,483 SH   SOLE   75,483 0 0
ECOLAB INC COM 278865100 13,699 66,509 SH   SOLE   66,509 0 0
EDISON INTL COM 281020107 3,178 54,966 SH   SOLE   54,966 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 11,691 112,878 SH   SOLE   112,878 0 0
ELANCO ANIMAL HEALTH INC COM 28414H103 780 22,491 SH   SOLE   22,491 0 0
ELECTRONIC ARTS INC COM 285512109 10,905 75,819 SH   SOLE   75,819 0 0
EMCOR GROUP INC COM 29084Q100 3,109 25,238 SH   SOLE   25,238 0 0
EMERSON ELEC CO COM 291011104 63,816 663,093 SH   SOLE   663,093 0 0
ENBRIDGE INC COM 29250N105 1,871 46,691 SH   SOLE   46,691 0 0
ENPHASE ENERGY INC COM 29355A107 27,896 151,915 SH   SOLE   151,915 0 0
ENPHASE ENERGY INC COM 29355A107 3 15 SH   OTR 1 0 0 15
ENTERGY CORP NEW COM 29364G103 1,169 11,724 SH   SOLE   11,724 0 0
ENVIVA PARTNERS LP COM UNIT 29414J107 3,485 66,496 SH   SOLE   66,496 0 0
EOG RES INC COM 26875P101 2,898 34,735 SH   SOLE   34,735 0 0
EPIZYME INC COM 29428V104 551 66,329 SH   SOLE   66,329 0 0
EQUIFAX INC COM 294429105 1,624 6,782 SH   SOLE   6,782 0 0
EQUINIX INC COM 29444U700 3 4 SH   OTR 1 0 0 4
EQUINIX INC COM 29444U700 44,018 54,844 SH   SOLE   54,844 0 0
EQUINOR ASA SPONSORED ADR 29446M102 1 66 SH   OTR 1 0 0 66
EQUITY LIFESTYLE PPTYS INC COM 29472R108 819 11,027 SH   SOLE   11,027 0 0
EQUITY LIFESTYLE PPTYS INC COM 29472R108 3 46 SH   OTR 1 0 0 46
EQUITY RESIDENTIAL SH BEN INT 29476L107 2,209 2,000 PRN   SOLE   2,000 0 0
EQUITY RESIDENTIAL SH BEN INT 29476L107 2,496 32,412 SH   SOLE   32,412 0 0
ERICSSON ADR B SEK 10 294821608 1,917 152,392 SH   SOLE   152,392 0 0
ERICSSON ADR B SEK 10 294821608 2 125 SH   OTR 1 0 0 125
ESSA PHARMA INC COM NEW 29668H708 8,585 300,505 SH   SOLE   300,505 0 0
ESSA PHARMA INC COM NEW 29668H708 1 20 SH   OTR 1 0 0 20
ESSENTIAL UTILS INC COM 29670G102 1,632 35,712 SH   SOLE   35,712 0 0
ESSEX PPTY TR INC COM 297178105 1,561 5,202 SH   SOLE   5,202 0 0
ETF MANAGERS TR PRIME CYBR SCRTY 26924G201 1,317 21,715 SH   SOLE   21,715 0 0
ETF MANAGERS TR WEDBUSH VID GAME 26924G706 318 3,335 SH   SOLE   3,335 0 0
ETSY INC COM 29786A106 4,556 22,136 SH   SOLE   22,136 0 0
EVEREST RE GROUP LTD COM G3223R108 1,612 6,396 SH   SOLE   6,396 0 0
EVERSOURCE ENERGY COM 30040W108 3,171 39,518 SH   SOLE   39,518 0 0
EXACT SCIENCES CORP COM 30063P105 29,707 238,977 SH   SOLE   238,977 0 0
EXACT SCIENCES CORP COM 30063P105 2 15 SH   OTR 1 0 0 15
EXACT SCIENCES CORP NOTE 0.375% 3/0 30063PAC9 1,240 1,000 PRN   SOLE   1,000 0 0
EXCHANGE TRADED CONCEPTS TR EMQQ EM INTERN 301505889 1,923 30,350 SH   SOLE   30,350 0 0
EXELIXIS INC COM 30161Q104 2 125 SH   OTR 1 0 0 125
EXELIXIS INC COM 30161Q104 50,430 2,767,822 SH   SOLE   2,767,822 0 0
EXELON CORP COM 30161N101 5,580 125,933 SH   SOLE   125,933 0 0
EXPEDIA GROUP INC COM NEW 30212P303 1,173 7,165 SH   SOLE   7,165 0 0
EXPEDITORS INTL WASH INC COM 302130109 3,791 3,500 PRN   SOLE   3,500 0 0
EXPEDITORS INTL WASH INC COM 302130109 1,679 13,265 SH   SOLE   13,265 0 0
EXPEDITORS INTL WASH INC COM 302130109 3 20 SH   OTR 1 0 0 20
EXTRA SPACE STORAGE INC COM 30225T102 955 5,827 SH   SOLE   5,827 0 0
EXXON MOBIL CORP COM 30231G102 23,409 371,097 SH   SOLE   371,097 0 0
FACEBOOK INC CL A 30303M102 176,159 506,625 SH   SOLE   506,625 0 0
FACEBOOK INC CL A 30303M102 5 13 SH   OTR 1 0 0 13
FASTENAL CO COM 311900104 2,941 56,562 SH   SOLE   56,562 0 0
FASTENAL CO COM 311900104 2 29 SH   OTR 1 0 0 29
FATE THERAPEUTICS INC COM 31189P102 1 8 SH   OTR 1 0 0 8
FATE THERAPEUTICS INC COM 31189P102 21,761 250,729 SH   SOLE   250,729 0 0
FEDEX CORP COM 31428X106 6,625 22,207 SH   SOLE   22,207 0 0
FERRO CORP COM 315405100 2,667 123,663 SH   SOLE   123,663 0 0
FIBROGEN INC COM 31572Q808 7,682 288,484 SH   SOLE   288,484 0 0
FIDELITY NATIONAL FINANCIAL FNF GROUP COM 31620R303 796 18,311 SH   SOLE   18,311 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 6,660 47,008 SH   SOLE   47,008 0 0
FIFTH THIRD BANCORP COM 316773100 5,319 139,132 SH   SOLE   139,132 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 1,899 10,145 SH   SOLE   10,145 0 0
FISERV INC COM 337738108 4,863 45,495 SH   SOLE   45,495 0 0
FIVE BELOW INC COM 33829M101 1,531 7,922 SH   SOLE   7,922 0 0
FLEETCOR TECHNOLOGIES INC COM 339041105 1,102 4,302 SH   SOLE   4,302 0 0
FLUIDIGM CORP DEL COM 34385P108 1,070 173,646 SH   SOLE   173,646 0 0
FLY LEASING LTD SPONSORED ADR 34407D109 4,390 259,121 SH   SOLE   259,121 0 0
FMC CORP COM NEW 302491303 1,464 13,530 SH   SOLE   13,530 0 0
FOMENTO ECONOMICO MEXICANO S SPON ADR UNITS 344419106 294 3,484 SH   SOLE   3,484 0 0
FORD MTR CO DEL COM 345370860 5,261 354,015 SH   SOLE   354,015 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 7,285 292,692 SH   SOLE   292,692 0 0
FORTERRA INC COM 34960W106 17,277 734,897 SH   SOLE   734,897 0 0
FORTINET INC COM 34959E109 1,494 6,273 SH   SOLE   6,273 0 0
FORTIS INC COM 349553107 2,772 2,500 PRN   SOLE   2,500 0 0
FORTIVE CORP COM 34959J108 3,251 46,612 SH   SOLE   46,612 0 0
FORTIVE CORP NOTE 0.875% 2/1 34959JAK4 11,567 11,500 PRN   SOLE   11,500 0 0
FORTRESS BIOTECH INC COM 34960Q109 80 22,500 SH   SOLE   22,500 0 0
FOX CORP CL A COM 35137L105 504 13,565 SH   SOLE   13,565 0 0
FOX CORP CL B COM 35137L204 1,001 28,435 SH   SOLE   28,435 0 0
FRANCO NEV CORP COM 351858105 733 5,045 SH   SOLE   5,045 0 0
FRANKLIN RESOURCES INC COM 354613101 1,354 42,328 SH   SOLE   42,328 0 0
FREEPORT-MCMORAN INC CL B 35671D857 2,816 75,873 SH   SOLE   75,873 0 0
FRESHPET INC COM 358039105 1,425 8,745 SH   SOLE   8,745 0 0
FTI CONSULTING INC COM 302941109 6,293 46,066 SH   SOLE   46,066 0 0
GALLAGHER ARTHUR J & CO COM 363576109 1,251 8,931 SH   SOLE   8,931 0 0
GAP INC COM 364760108 368 10,937 SH   SOLE   10,937 0 0
GARMIN LTD SHS H2906T109 2 17 SH   OTR 1 0 0 17
GENERAC HLDGS INC COM 368736104 4,366 10,517 SH   SOLE   10,517 0 0
GENERAL ELECTRIC CO COM 369604103 9,319 692,340 SH   SOLE   692,340 0 0
GENERAL MLS INC COM 370334104 12,980 213,039 SH   SOLE   213,039 0 0
GENERAL MTRS CO COM 37045V100 6,539 110,515 SH   SOLE   110,515 0 0
GENMAB A/S SPONSORED ADS 372303206 6 136 SH   OTR 1 0 0 136
GENUINE PARTS CO COM 372460105 1,443 11,409 SH   SOLE   11,409 0 0
GILDAN ACTIVEWEAR INC COM 375916103 5,340 144,574 SH   SOLE   144,574 0 0
GILEAD SCIENCES INC COM 375558103 2 24 SH   OTR 1 0 0 24
GILEAD SCIENCES INC COM 375558103 109,631 1,592,082 SH   SOLE   1,592,082 0 0
GLADSTONE COMMERCIAL CORP COM 376536108 225 9,980 SH   SOLE   9,980 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 4 92 SH   OTR 1 0 0 92
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 6,875 196,330 SH   SOLE   196,330 0 0
GLOBAL PMTS INC COM 37940X102 3,027 16,143 SH   SOLE   16,143 0 0
GLOBAL X FDS GLOBAL X COPPER 37954Y830 503 13,550 SH   SOLE   13,550 0 0
GLOBUS MED INC CL A 379577208 2,714 35,000 SH   SOLE   35,000 0 0
GODADDY INC CL A 380237107 3,571 41,063 SH   SOLE   41,063 0 0
GOLD FIELDS LTD SPONSORED ADR 38059T106 196 22,021 SH   SOLE   22,021 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 5,516 14,535 SH   SOLE   14,535 0 0
GOODYEAR TIRE & RUBR CO COM 382550101 223 13,031 SH   SOLE   13,031 0 0
GRACE W R & CO DEL NEW COM 38388F108 22,517 325,773 SH   SOLE   325,773 0 0
GRAINGER W W INC COM 384802104 915 800 PRN   SOLE   800 0 0
GRAINGER W W INC COM 384802104 6,117 13,966 SH   SOLE   13,966 0 0
GUARDANT HEALTH INC COM 40131M109 1 5 SH   OTR 1 0 0 5
GUARDANT HEALTH INC COM 40131M109 12,132 97,691 SH   SOLE   97,691 0 0
HAIN CELESTIAL GROUP INC COM 405217100 3,213 80,083 SH   SOLE   80,083 0 0
HALLIBURTON CO COM 406216101 5,988 259,002 SH   SOLE   259,002 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 1 13 SH   OTR 1 0 0 13
HALOZYME THERAPEUTICS INC COM 40637H109 24,926 548,917 SH   SOLE   548,917 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 23,438 417,425 SH   SOLE   417,425 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 3 46 SH   OTR 1 0 0 46
HARPOON THERAPEUTICS INC COM 41358P106 6,789 489,481 SH   SOLE   489,481 0 0
HARPOON THERAPEUTICS INC COM 41358P106 0 33 SH   OTR 1 0 0 33
HARTFORD FINL SVCS GROUP INC COM 416515104 2,222 35,848 SH   SOLE   35,848 0 0
HASBRO INC COM 418056107 8,089 85,582 SH   SOLE   85,582 0 0
HCA HEALTHCARE INC COM 40412C101 6,442 31,158 SH   SOLE   31,158 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 2,669 36,500 SH   SOLE   36,500 0 0
HEADHUNTER GROUP PLC SPONSORED ADS 42207L106 5,457 128,800 SH   SOLE   128,800 0 0
HEALTHPEAK PROPERTIES INC COM 42250P103 7,805 234,461 SH   SOLE   234,461 0 0
HEICO CORP NEW CL A 422806208 1,121 9,030 SH   SOLE   9,030 0 0
HENRY JACK & ASSOC INC COM 426281101 7,699 47,084 SH   SOLE   47,084 0 0
HENRY SCHEIN INC COM 806407102 295 3,981 SH   SOLE   3,981 0 0
HERON THERAPEUTICS INC COM 427746102 11,773 758,570 SH   SOLE   758,570 0 0
HERSHEY CO COM 427866108 5,558 31,911 SH   SOLE   31,911 0 0
HERSHEY CO COM 427866108 4 22 SH   OTR 1 0 0 22
HESS CORP COM 42809H107 1,858 21,282 SH   SOLE   21,282 0 0
HEWLETT PACKARD ENTERPRISE C COM 42824C109 2,006 137,579 SH   SOLE   137,579 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 18,864 156,388 SH   SOLE   156,388 0 0
HOLOGIC INC COM 436440101 26,432 396,160 SH   SOLE   396,160 0 0
HOLOGIC INC COM 436440101 2 23 SH   OTR 1 0 0 23
HOME DEPOT INC COM 437076102 77,077 241,705 SH   SOLE   241,705 0 0
HOME DEPOT INC COM 437076102 5 17 SH   OTR 1 0 0 17
HONEYWELL INTL INC COM 438516106 3,940 17,963 SH   SOLE   17,963 0 0
HORMEL FOODS CORP COM 440452100 1,395 29,217 SH   SOLE   29,217 0 0
HOST HOTELS & RESORTS INC COM 44107P104 1,180 69,074 SH   SOLE   69,074 0 0
HOWMET AEROSPACE INC COM 443201108 861 24,980 SH   SOLE   24,980 0 0
HP INC COM 40434L105 19,898 659,089 SH   SOLE   659,089 0 0
HP INC COM 40434L105 2 61 SH   OTR 1 0 0 61
HUAZHU GROUP LTD NOTE 0.375%11/0 16949NAC3 763 600 PRN   SOLE   600 0 0
HUBSPOT INC COM 443573100 3,425 5,878 SH   SOLE   5,878 0 0
HUMANA INC COM 444859102 5,591 12,629 SH   SOLE   12,629 0 0
HUNTINGTON BANCSHARES INC COM 446150104 10,585 741,771 SH   SOLE   741,771 0 0
HUNTINGTON INGALLS INDS INC COM 446413106 405 1,921 SH   SOLE   1,921 0 0
ICAD INC COM NEW 44934S206 300 17,332 SH   SOLE   17,332 0 0
ICICI BANK LIMITED ADR 45104G104 17,123 1,001,321 SH   SOLE   1,001,321 0 0
IDEX CORP COM 45167R104 8,831 40,134 SH   SOLE   40,134 0 0
IDEXX LABS INC COM 45168D104 31,531 49,926 SH   SOLE   49,926 0 0
IGM BIOSCIENCES INC COM 449585108 10,152 122,024 SH   SOLE   122,024 0 0
IGM BIOSCIENCES INC COM 449585108 0 5 SH   OTR 1 0 0 5
IHS MARKIT LTD SHS G47567105 31,154 276,529 SH   SOLE   276,529 0 0
ILLINOIS TOOL WKS INC COM 452308109 25,760 115,227 SH   SOLE   115,227 0 0
ILLUMINA INC COM 452327109 1 2 SH   OTR 1 0 0 2
ILLUMINA INC COM 452327109 92,883 196,283 SH   SOLE   196,283 0 0
ILLUMINA INC NOTE 8/1 452327AK5 3,697 2,900 PRN   SOLE   2,900 0 0
IMMUNOGEN INC COM 45253H101 16,220 2,461,363 SH   SOLE   2,461,363 0 0
IMMUNOGEN INC COM 45253H101 1 96 SH   OTR 1 0 0 96
INCYTE CORP COM 45337C102 56,525 671,875 SH   SOLE   671,875 0 0
INCYTE CORP COM 45337C102 2 19 SH   OTR 1 0 0 19
INFOSYS LTD SPONSORED ADR 456788108 7,069 333,594 SH   SOLE   333,594 0 0
INGERSOLL RAND INC COM 45687V106 1,599 32,769 SH   SOLE   32,769 0 0
INGREDION INC COM 457187102 264 2,921 SH   SOLE   2,921 0 0
INSMED INC COM PAR $.01 457669307 14,379 505,241 SH   SOLE   505,241 0 0
INSMED INC NOTE 1.750% 1/1 457669AA7 317 300 PRN   SOLE   300 0 0
INSULET CORP COM 45784P101 1,123 4,092 SH   SOLE   4,092 0 0
INSULET CORP NOTE 0.375% 9/0 45784PAK7 681 500 PRN   SOLE   500 0 0
INTEL CORP COM 458140100 4 63 SH   OTR 1 0 0 63
INTEL CORP COM 458140100 17,562 312,817 SH   SOLE   312,817 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 16,373 101,127 SH   SOLE   101,127 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 9,124 76,862 SH   SOLE   76,862 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 16,836 114,852 SH   SOLE   114,852 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 4 27 SH   OTR 1 0 0 27
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 3,912 26,183 SH   SOLE   26,183 0 0
INTERNATIONAL PAPER CO COM 460146103 1,640 26,742 SH   SOLE   26,742 0 0
INTERPUBLIC GROUP COS INC COM 460690100 21,321 656,238 SH   SOLE   656,238 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 13,041 319,487 SH   SOLE   319,487 0 0
INTUIT COM 461202103 15,137 30,881 SH   SOLE   30,881 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 42,217 45,906 SH   SOLE   45,906 0 0
INVESCO EXCHANGE TRADED FD T WILDERHIL CLAN 46137V134 431 4,620 SH   SOLE   4,620 0 0
INVITATION HOMES INC COM 46187W107 961 25,784 SH   SOLE   25,784 0 0
IONIS PHARMACEUTICALS INC COM 462222100 22,042 552,566 SH   SOLE   552,566 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 26,551 1,020,392 SH   SOLE   1,020,392 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 1 34 SH   OTR 1 0 0 34
IQIYI INC NOTE 3.750%12/0 46267XAB4 1,017 1,000 PRN   SOLE   1,000 0 0
IQVIA HLDGS INC COM 46266C105 2 10 SH   OTR 1 0 0 10
IQVIA HLDGS INC COM 46266C105 48,869 201,670 SH   SOLE   201,670 0 0
IRON MTN INC NEW COM 46284V101 1,238 29,249 SH   SOLE   29,249 0 0
ISHARES INC MSCI CDA ETF 464286509 4,223 113,314 SH   SOLE   113,314 0 0
ISHARES TR GL CLEAN ENE ETF 464288224 497 21,200 SH   SOLE   21,200 0 0
ISHARES TR ISHARES SEMICDTR 464287523 668 1,470 SH   SOLE   1,470 0 0
ISHARES TR U.S. MED DVC ETF 464288810 249 690 SH   SOLE   690 0 0
ISORAY INC COM 46489V104 28 34,883 SH   SOLE   34,883 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 924 153,665 SH   SOLE   153,665 0 0
ITEOS THERAPEUTICS INC COM 46565G104 12,950 504,859 SH   SOLE   504,859 0 0
ITEOS THERAPEUTICS INC COM 46565G104 1 31 SH   OTR 1 0 0 31
IVERIC BIO INC COM 46583P102 4,263 675,575 SH   SOLE   675,575 0 0
JAZZ INVESTMENTS I LTD NOTE 1.500% 8/1 472145AD3 2,217 2,000 PRN   SOLE   2,000 0 0
JAZZ INVESTMENTS I LTD NOTE 2.000% 6/1 472145AF8 801 600 PRN   SOLE   600 0 0
JBG SMITH PPTYS COM 46590V100 4,626 146,796 SH   SOLE   146,796 0 0
JD.COM INC SPON ADR CL A 47215P106 33,573 420,659 SH   SOLE   420,659 0 0
JOHNSON & JOHNSON COM 478160104 8 46 SH   OTR 1 0 0 46
JOHNSON & JOHNSON COM 478160104 106,282 645,148 SH   SOLE   645,148 0 0
JOUNCE THERAPEUTICS INC COM 481116101 0 16 SH   OTR 1 0 0 16
JOUNCE THERAPEUTICS INC COM 481116101 2,294 337,382 SH   SOLE   337,382 0 0
JOYY INC NOTE 0.750% 6/1 98426TAD8 506 500 PRN   SOLE   500 0 0
JPMORGAN CHASE & CO COM 46625H100 47,481 305,267 SH   SOLE   305,267 0 0
KANSAS CITY SOUTHERN COM NEW 485170302 12,747 44,985 SH   SOLE   44,985 0 0
KARUNA THERAPEUTICS INC COM 48576A100 6,241 54,750 SH   SOLE   54,750 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 0 44 SH   OTR 1 0 0 44
KARYOPHARM THERAPEUTICS INC COM 48576U106 7,406 717,624 SH   SOLE   717,624 0 0
KELLOGG CO COM 487836108 2 28 SH   OTR 1 0 0 28
KELLOGG CO COM 487836108 2,076 32,272 SH   SOLE   32,272 0 0
KEROS THERAPEUTICS INC COM 492327101 4,307 101,409 SH   SOLE   101,409 0 0
KEURIG DR PEPPER INC COM 49271V100 1 31 SH   OTR 1 0 0 31
KEURIG DR PEPPER INC COM 49271V100 1,819 51,624 SH   SOLE   51,624 0 0
KEYCORP COM 493267108 1 70 SH   OTR 1 0 0 70
KEYCORP COM 493267108 14,044 680,092 SH   SOLE   680,092 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 31,622 204,795 SH   SOLE   204,795 0 0
KIMBERLY-CLARK CORP COM 494368103 4,927 36,829 SH   SOLE   36,829 0 0
KIMCO RLTY CORP COM 49446R109 227 10,900 SH   SOLE   10,900 0 0
KINDER MORGAN INC DEL COM 49456B101 19,684 1,079,768 SH   SOLE   1,079,768 0 0
KINROSS GOLD CORP COM 496902404 310 48,799 SH   SOLE   48,799 0 0
KKR & CO INC COM 48251W104 2,889 48,774 SH   SOLE   48,774 0 0
KLA CORP COM NEW 482480100 14,160 43,674 SH   SOLE   43,674 0 0
KNOLL INC COM NEW 498904200 4,798 184,616 SH   SOLE   184,616 0 0
KODIAK SCIENCES INC COM 50015M109 3,086 33,186 SH   SOLE   33,186 0 0
KRAFT HEINZ CO COM 500754106 2,678 65,659 SH   SOLE   65,659 0 0
KROGER CO COM 501044101 17,599 459,397 SH   SOLE   459,397 0 0
KROGER CO COM 501044101 3 77 SH   OTR 1 0 0 77
KULICKE & SOFFA INDS INC COM 501242101 4,126 67,421 SH   SOLE   67,421 0 0
KURA ONCOLOGY INC COM 50127T109 19,731 946,321 SH   SOLE   946,321 0 0
KURA ONCOLOGY INC COM 50127T109 1 36 SH   OTR 1 0 0 36
KYMERA THERAPEUTICS INC COM 501575104 1 17 SH   OTR 1 0 0 17
KYMERA THERAPEUTICS INC COM 501575104 19,932 410,974 SH   SOLE   410,974 0 0
L BRANDS INC COM 501797104 1,067 14,813 SH   SOLE   14,813 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 12,453 45,145 SH   SOLE   45,145 0 0
LAM RESEARCH CORP COM 512807108 1,157 1,000 PRN   SOLE   1,000 0 0
LAM RESEARCH CORP COM 512807108 29,857 45,884 SH   SOLE   45,884 0 0
LAMB WESTON HLDGS INC COM 513272104 924 11,455 SH   SOLE   11,455 0 0
LAS VEGAS SANDS CORP COM 517834107 1,041 19,766 SH   SOLE   19,766 0 0
LAUDER ESTEE COS INC CL A 518439104 51,065 160,540 SH   SOLE   160,540 0 0
LAUDER ESTEE COS INC CL A 518439104 1 2 SH   OTR 1 0 0 2
LEMONADE INC COM 52567D107 602 5,500 SH   SOLE   5,500 0 0
LENNAR CORP CL A 526057104 1,490 15,000 SH   SOLE   15,000 0 0
LENNOX INTL INC COM 526107107 3,234 9,218 SH   SOLE   9,218 0 0
LI AUTO INC SPONSORED ADS 50202M102 226 6,473 SH   SOLE   6,473 0 0
LIBERTY BROADBAND CORP COM SER C 530307305 1,464 8,432 SH   SOLE   8,432 0 0
LIBERTY MEDIA CORP DEL COM C SIRIUSXM 531229607 771 16,612 SH   SOLE   16,612 0 0
LILLY ELI & CO COM 532457108 27,953 121,791 SH   SOLE   121,791 0 0
LINCOLN NATL CORP IND COM 534187109 1,125 17,900 SH   SOLE   17,900 0 0
LINDE PLC SHS G5494J103 1 5 SH   OTR 1 0 0 5
LITHIUM AMERS CORP NEW COM NEW 53680Q207 630 42,463 SH   SOLE   42,463 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 855 9,760 SH   SOLE   9,760 0 0
LKQ CORP COM 501889208 2,070 42,048 SH   SOLE   42,048 0 0
LOEWS CORP COM 540424108 2,425 44,378 SH   SOLE   44,378 0 0
LOUISIANA PAC CORP COM 546347105 7,762 128,748 SH   SOLE   128,748 0 0
LOWES COS INC COM 548661107 53,415 275,377 SH   SOLE   275,377 0 0
LULULEMON ATHLETICA INC COM 550021109 18,363 50,313 SH   SOLE   50,313 0 0
LUMEN TECHNOLOGIES INC COM 550241103 900 66,231 SH   SOLE   66,231 0 0
LUMENTUM HLDGS INC NOTE 0.500%12/1 55024UAD1 1,088 1,000 PRN   SOLE   1,000 0 0
LUMINEX CORP DEL COM 55027E102 17,610 478,532 SH   SOLE   478,532 0 0
LYDALL INC COM 550819106 6,003 99,198 SH   SOLE   99,198 0 0
LYFT INC CL A COM 55087P104 591 9,772 SH   SOLE   9,772 0 0
M & T BK CORP COM 55261F104 1,450 9,982 SH   SOLE   9,982 0 0
MACROGENICS INC COM 556099109 16,344 608,499 SH   SOLE   608,499 0 0
MACROGENICS INC COM 556099109 1 24 SH   OTR 1 0 0 24
MAGELLAN HEALTH INC COM NEW 559079207 18,258 193,817 SH   SOLE   193,817 0 0
MAGNA INTL INC COM 559222401 1,295 13,970 SH   SOLE   13,970 0 0
MANNKIND CORP COM NEW 56400P706 63 11,500 SH   SOLE   11,500 0 0
MANPOWERGROUP INC WIS COM 56418H100 9,242 77,722 SH   SOLE   77,722 0 0
MANULIFE FINL CORP COM 56501R106 3,900 197,927 SH   SOLE   197,927 0 0
MARATHON OIL CORP COM 565849106 960 70,479 SH   SOLE   70,479 0 0
MARATHON PETE CORP COM 56585A102 2,128 35,217 SH   SOLE   35,217 0 0
MARKEL CORP COM 570535104 822 693 SH   SOLE   693 0 0
MARKETAXESS HLDGS INC COM 57060D108 1,009 2,176 SH   SOLE   2,176 0 0
MARRIOTT INTL INC NEW CL A 571903202 8,146 59,667 SH   SOLE   59,667 0 0
MARSH & MCLENNAN COS INC COM 571748102 5,368 38,158 SH   SOLE   38,158 0 0
MARSH & MCLENNAN COS INC COM 571748102 1 8 SH   OTR 1 0 0 8
MARTIN MARIETTA MATLS INC COM 573284106 3,945 11,213 SH   SOLE   11,213 0 0
MARVELL TECHNOLOGY INC COM 573874104 2,792 47,862 SH   SOLE   47,862 0 0
MASCO CORP COM 574599106 2 36 SH   OTR 1 0 0 36
MASCO CORP COM 574599106 17,014 288,818 SH   SOLE   288,818 0 0
MASIMO CORP COM 574795100 5,113 21,090 SH   SOLE   21,090 0 0
MASTEC INC COM 576323109 2 19 SH   OTR 1 0 0 19
MASTEC INC COM 576323109 18,836 177,529 SH   SOLE   177,529 0 0
MASTERCARD INCORPORATED CL A 57636Q104 53,465 146,444 SH   SOLE   146,444 0 0
MASTERCARD INCORPORATED CL A 57636Q104 1 3 SH   OTR 1 0 0 3
MATCH GROUP INC NEW COM 57667L107 2,102 13,035 SH   SOLE   13,035 0 0
MAXIM INTEGRATED PRODS INC COM 57772K101 48,529 460,606 SH   SOLE   460,606 0 0
MCCORMICK & CO INC COM NON VTG 579780206 11,570 130,997 SH   SOLE   130,997 0 0
MCCORMICK & CO INC COM NON VTG 579780206 1 8 SH   OTR 1 0 0 8
MCDONALDS CORP COM 580135101 55,882 241,922 SH   SOLE   241,922 0 0
MCDONALDS CORP COM 580135101 2 7 SH   OTR 1 0 0 7
MCKESSON CORP COM 58155Q103 1,850 9,676 SH   SOLE   9,676 0 0
MEDTRONIC PLC SHS G5960L103 5 37 SH   OTR 1 0 0 37
MERCADOLIBRE INC COM 58733R102 33,706 21,637 SH   SOLE   21,637 0 0
MERCK & CO INC COM 58933Y105 18 226 SH   OTR 1 0 0 226
MERCK & CO INC COM 58933Y105 335,817 4,318,081 SH   SOLE   4,318,081 0 0
MERIDIAN BANCORP INC MD COM 58958U103 305 14,912 SH   SOLE   14,912 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1 79 SH   OTR 1 0 0 79
MERSANA THERAPEUTICS INC COM 59045L106 26,791 1,972,816 SH   SOLE   1,972,816 0 0
MERUS N V COM N5749R100 1 44 SH   OTR 1 0 0 44
MESA LABS INC COM 59064R109 1,789 6,597 SH   SOLE   6,597 0 0
METLIFE INC COM 59156R108 8,178 136,638 SH   SOLE   136,638 0 0
METLIFE INC COM 59156R108 3 50 SH   OTR 1 0 0 50
METTLER TOLEDO INTERNATIONAL COM 592688105 25,499 18,406 SH   SOLE   18,406 0 0
MGM RESORTS INTERNATIONAL COM 552953101 1,025 24,030 SH   SOLE   24,030 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 2,398 16,012 SH   SOLE   16,012 0 0
MICRON TECHNOLOGY INC COM 595112103 6,229 73,297 SH   SOLE   73,297 0 0
MICRON TECHNOLOGY INC COM 595112103 2 23 SH   OTR 1 0 0 23
MICROSOFT CORP COM 594918104 673,455 2,485,992 SH   SOLE   2,485,992 0 0
MICROSOFT CORP COM 594918104 25 92 SH   OTR 1 0 0 92
MID-AMER APT CMNTYS INC COM 59522J103 4,897 29,075 SH   SOLE   29,075 0 0
MIRATI THERAPEUTICS INC COM 60468T105 55,822 345,583 SH   SOLE   345,583 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2 13 SH   OTR 1 0 0 13
MOBILE TELESYSTEMS PJSC SPONSORED ADR 607409109 5,223 564,000 SH   SOLE   564,000 0 0
MODERNA INC COM 60770K107 72,142 307,014 SH   SOLE   307,014 0 0
MOHAWK INDS INC COM 608190104 1,484 7,720 SH   SOLE   7,720 0 0
MOLINA HEALTHCARE INC COM 60855R100 674 2,662 SH   SOLE   2,662 0 0
MOLSON COORS BEVERAGE CO CL B 60871R209 759 14,134 SH   SOLE   14,134 0 0
MONDELEZ INTL INC CL A 609207105 9,302 148,972 SH   SOLE   148,972 0 0
MONGODB INC CL A 60937P106 1,578 4,365 SH   SOLE   4,365 0 0
MONGODB INC NOTE 0.250% 1/1 60937PAD8 728 400 PRN   SOLE   400 0 0
MONSTER BEVERAGE CORP NEW COM 61174X109 3,137 34,343 SH   SOLE   34,343 0 0
MOODYS CORP COM 615369105 477 500 PRN   SOLE   500 0 0
MOODYS CORP COM 615369105 11,113 30,667 SH   SOLE   30,667 0 0
MORGAN STANLEY COM NEW 617446448 20,391 222,388 SH   SOLE   222,388 0 0
MORGAN STANLEY COM NEW 617446448 4 43 SH   OTR 1 0 0 43
MORGAN STANLEY COM NEW 617446448 723 500 PRN   SOLE   500 0 0
MORPHOSYS AG SPONSORED ADS 617760202 5,174 268,778 SH   SOLE   268,778 0 0
MORPHOSYS AG SPONSORED ADS 617760202 1 57 SH   OTR 1 0 0 57
MOSAIC CO NEW COM 61945C103 1,684 52,779 SH   SOLE   52,779 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 2,405 11,092 SH   SOLE   11,092 0 0
MR COOPER GROUP INC COM 62482R107 664 20,096 SH   SOLE   20,096 0 0
MSCI INC COM 55354G100 2,430 4,558 SH   SOLE   4,558 0 0
MYMD PHARMACEUTICALS INC COM 62856X102 114 18,073 SH   SOLE   18,073 0 0
NATIONAL FUEL GAS CO COM 636180101 561 10,738 SH   SOLE   10,738 0 0
NATURA &CO HLDG S A ADS 63884N108 234 10,298 SH   SOLE   10,298 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 1,566 155,000 SH   SOLE   155,000 0 0
NEOGENOMICS INC COM NEW 64049M209 8,461 187,319 SH   SOLE   187,319 0 0
NEOGENOMICS INC COM NEW 64049M209 1 13 SH   OTR 1 0 0 13
NEOLEUKIN THERAPEUTICS INC COM 64049K104 0 35 SH   OTR 1 0 0 35
NEOLEUKIN THERAPEUTICS INC COM 64049K104 4,726 511,978 SH   SOLE   511,978 0 0
NETAPP INC COM 64110D104 1,054 12,887 SH   SOLE   12,887 0 0
NETEASE INC SPONSORED ADS 64110W102 4,397 38,150 SH   SOLE   38,150 0 0
NETFLIX INC COM 64110L106 22,896 43,346 SH   SOLE   43,346 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 7,931 81,493 SH   SOLE   81,493 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 6,869 838,660 SH   SOLE   838,660 0 0
NEWELL BRANDS INC COM 651229106 2,370 86,289 SH   SOLE   86,289 0 0
NEWMONT CORP COM 651639106 7,946 125,371 SH   SOLE   125,371 0 0
NEWMONT CORP COM 651639106 2 26 SH   OTR 1 0 0 26
NEWS CORP NEW CL A 65249B109 611 23,724 SH   SOLE   23,724 0 0
NEXTERA ENERGY INC COM 65339F101 38,856 530,240 SH   SOLE   530,240 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 33,701 441,347 SH   SOLE   441,347 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 3 40 SH   OTR 1 0 0 40
NGM BIOPHARMACEUTICALS INC COM 62921N105 11,123 564,059 SH   SOLE   564,059 0 0
NIKE INC CL B 654106103 5 31 SH   OTR 1 0 0 31
NIKE INC CL B 654106103 99,816 646,097 SH   SOLE   646,097 0 0
NIO INC SPON ADS 62914V106 43,513 817,916 SH   SOLE   817,916 0 0
NKARTA INC COM 65487U108 0 4 SH   OTR 1 0 0 4
NOMAD FOODS LTD USD ORD SHS G6564A105 3,167 112,044 SH   SOLE   112,044 0 0
NORFOLK SOUTHN CORP COM 655844108 16,417 61,855 SH   SOLE   61,855 0 0
NORTHERN TR CORP COM 665859104 5,529 47,821 SH   SOLE   47,821 0 0
NORTONLIFELOCK INC COM 668771108 1,163 42,729 SH   SOLE   42,729 0 0
NOVAVAX INC COM NEW 670002401 26,183 123,323 SH   SOLE   123,323 0 0
NOVOCURE LTD ORD SHS G6674U108 1 3 SH   OTR 1 0 0 3
NOVO-NORDISK A S ADR 670100205 2 28 SH   OTR 1 0 0 28
NU SKIN ENTERPRISES INC CL A 67018T105 3,618 63,871 SH   SOLE   63,871 0 0
NUANCE COMMUNICATIONS INC COM 67020Y100 22,790 418,618 SH   SOLE   418,618 0 0
NUCOR CORP COM 670346105 2,257 23,526 SH   SOLE   23,526 0 0
NURIX THERAPEUTICS INC COM 67080M103 13,458 507,287 SH   SOLE   507,287 0 0
NURIX THERAPEUTICS INC COM 67080M103 0 16 SH   OTR 1 0 0 16
NUTRIEN LTD COM 67077M108 839 13,835 SH   SOLE   13,835 0 0
NVIDIA CORPORATION COM 67066G104 126,973 158,696 SH   SOLE   158,696 0 0
NVR INC COM 62944T105 1,373 276 SH   SOLE   276 0 0
OCCIDENTAL PETE CORP COM 674599105 1,577 50,421 SH   SOLE   50,421 0 0
OKTA INC CL A 679295105 8,262 33,765 SH   SOLE   33,765 0 0
OKTA INC NOTE 0.375% 6/1 679295AF2 1,621 1,300 PRN   SOLE   1,300 0 0
OLD DOMINION FREIGHT LINE IN COM 679580100 4,237 16,694 SH   SOLE   16,694 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 9,780 349,551 SH   SOLE   349,551 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 1 21 SH   OTR 1 0 0 21
OMNICOM GROUP INC COM 681919106 2 24 SH   OTR 1 0 0 24
OMNICOM GROUP INC COM 681919106 1,908 23,851 SH   SOLE   23,851 0 0
ON SEMICONDUCTOR CORP COM 682189105 3 79 SH   OTR 1 0 0 79
ON SEMICONDUCTOR CORP COM 682189105 58,269 1,522,186 SH   SOLE   1,522,186 0 0
ONEOK INC NEW COM 682680103 2,308 41,489 SH   SOLE   41,489 0 0
ORACLE CORP COM 68389X105 13,472 173,069 SH   SOLE   173,069 0 0
ORBCOMM INC COM 68555P100 9,456 841,269 SH   SOLE   841,269 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 3,817 6,742 SH   SOLE   6,742 0 0
ORGANON & CO COMMON STOCK 68622V106 1,552 51,274 SH   SOLE   51,274 0 0
ORMAT TECHNOLOGIES INC COM 686688102 1,235 17,755 SH   SOLE   17,755 0 0
ORTHOPEDIATRICS CORP COM 68752L100 4,193 66,369 SH   SOLE   66,369 0 0
OTIS WORLDWIDE CORP COM 68902V107 23,044 281,820 SH   SOLE   281,820 0 0
OTIS WORLDWIDE CORP COM 68902V107 1 18 SH   OTR 1 0 0 18
OUTSET MED INC COM 690145107 4,376 87,555 SH   SOLE   87,555 0 0
OWENS CORNING NEW COM 690742101 2 23 SH   OTR 1 0 0 23
OWENS CORNING NEW COM 690742101 1,356 1,300 PRN   SOLE   1,300 0 0
OWENS CORNING NEW COM 690742101 47,672 486,950 SH   SOLE   486,950 0 0
PACCAR INC COM 693718108 3,829 42,900 SH   SOLE   42,900 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 9,807 280,431 SH   SOLE   280,431 0 0
PACKAGING CORP AMER COM 695156109 821 6,059 SH   SOLE   6,059 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 10,723 191,750 SH   SOLE   191,750 0 0
PALO ALTO NETWORKS INC COM 697435105 3 7 SH   OTR 1 0 0 7
PALO ALTO NETWORKS INC COM 697435105 78,848 212,499 SH   SOLE   212,499 0 0
PALO ALTO NETWORKS INC NOTE 0.375% 6/0 697435AF2 3,251 1,390,000 PRN   SOLE   1,390,000 0 0
PALO ALTO NETWORKS INC NOTE 0.750% 7/0 697435AD7 2,190 1,500 PRN   SOLE   1,500 0 0
PAN AMERN SILVER CORP COM 697900108 2,560 89,600 SH   SOLE   89,600 0 0
PARKER-HANNIFIN CORP COM 701094104 22,297 72,603 SH   SOLE   72,603 0 0
PAYCHEX INC COM 704326107 2,227 20,754 SH   SOLE   20,754 0 0
PAYCOM SOFTWARE INC COM 70432V102 1,148 3,158 SH   SOLE   3,158 0 0
PAYPAL HLDGS INC COM 70450Y103 109,176 374,557 SH   SOLE   374,557 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 5,557 44,807 SH   SOLE   44,807 0 0
PEMBINA PIPELINE CORP COM 706327103 481 15,130 SH   SOLE   15,130 0 0
PENTAIR PLC SHS G7S00T104 1 17 SH   OTR 1 0 0 17
PEOPLES UNITED FINANCIAL INC COM 712704105 208 12,163 SH   SOLE   12,163 0 0
PEPSICO INC COM 713448108 4 29 SH   OTR 1 0 0 29
PEPSICO INC COM 713448108 26,893 181,504 SH   SOLE   181,504 0 0
PERKINELMER INC COM 714046109 4,405 28,531 SH   SOLE   28,531 0 0
PERSONALIS INC COM 71535D106 8,143 321,846 SH   SOLE   321,846 0 0
PERSONALIS INC COM 71535D106 1 21 SH   OTR 1 0 0 21
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 308 25,150 SH   SOLE   25,150 0 0
PFIZER INC COM 717081103 4,888 124,825 SH   SOLE   124,825 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 2,304 619,434 SH   SOLE   619,434 0 0
PHILLIPS 66 COM 718546104 3,340 38,913 SH   SOLE   38,913 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 4,067 1,061,834 SH   SOLE   1,061,834 0 0
PINDUODUO INC NOTE 12/0 722304AC6 1,450 1,400 PRN   SOLE   1,400 0 0
PINDUODUO INC SPONSORED ADS 722304102 43,027 338,743 SH   SOLE   338,743 0 0
PINTEREST INC CL A 72352L106 2,462 31,181 SH   SOLE   31,181 0 0
PIONEER NAT RES CO COM 723787107 1,934 11,898 SH   SOLE   11,898 0 0
PLANET FITNESS INC CL A 72703H101 5,818 77,320 SH   SOLE   77,320 0 0
PLUG POWER INC COM NEW 72919P202 1,214 35,495 SH   SOLE   35,495 0 0
PNC FINL SVCS GROUP INC COM 693475105 20,718 108,608 SH   SOLE   108,608 0 0
POOL CORP COM 73278L105 255 556 SH   SOLE   556 0 0
POTLATCHDELTIC CORPORATION COM 737630103 1,724 32,428 SH   SOLE   32,428 0 0
POWER INTEGRATIONS INC COM 739276103 22,464 273,757 SH   SOLE   273,757 0 0
POWER INTEGRATIONS INC COM 739276103 2 30 SH   OTR 1 0 0 30
PPD INC COM 69355F102 18,296 396,971 SH   SOLE   396,971 0 0
PPG INDS INC COM 693506107 15,966 94,042 SH   SOLE   94,042 0 0
PRA HEALTH SCIENCES INC COM 69354M108 14,463 87,515 SH   SOLE   87,515 0 0
PRECISION BIOSCIENCES INC COM 74019P108 7,927 633,162 SH   SOLE   633,162 0 0
PRICE T ROWE GROUP INC COM 74144T108 5,867 29,636 SH   SOLE   29,636 0 0
PRICELINE GRP INC NOTE 0.900% 9/1 741503AX4 19,148 17,522 PRN   SOLE   17,522 0 0
PRINCIPAL FINANCIAL GROUP IN COM 74251V102 1,800 28,483 SH   SOLE   28,483 0 0
PROCTER AND GAMBLE CO COM 742718109 7 52 SH   OTR 1 0 0 52
PROCTER AND GAMBLE CO COM 742718109 117,198 868,581 SH   SOLE   868,581 0 0
PROGRESSIVE CORP COM 743315103 3,450 35,129 SH   SOLE   35,129 0 0
PROLOGIS INC. COM 74340W103 31,732 265,477 SH   SOLE   265,477 0 0
PROOFPOINT INC COM 743424103 17,199 98,981 SH   SOLE   98,981 0 0
PROOFPOINT INC NOTE 0.250% 8/1 743424AF0 753 600 PRN   SOLE   600 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 3,754 83,646 SH   SOLE   83,646 0 0
PRUDENTIAL FINL INC COM 744320102 5,774 56,351 SH   SOLE   56,351 0 0
PRUDENTIAL FINL INC COM 744320102 4 37 SH   OTR 1 0 0 37
PTC INC COM 69370C100 46,490 329,110 SH   SOLE   329,110 0 0
PTC THERAPEUTICS INC COM 69366J200 11,556 273,374 SH   SOLE   273,374 0 0
PUBLIC STORAGE COM 74460D109 2,621 8,716 SH   SOLE   8,716 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 2,412 40,380 SH   SOLE   40,380 0 0
PULTE GROUP INC COM 745867101 1,927 35,316 SH   SOLE   35,316 0 0
QORVO INC COM 74736K101 24,997 127,763 SH   SOLE   127,763 0 0
QUALCOMM INC COM 747525103 96,070 672,149 SH   SOLE   672,149 0 0
QUALCOMM INC COM 747525103 2 14 SH   OTR 1 0 0 14
QUEST DIAGNOSTICS INC COM 74834L100 9,303 70,495 SH   SOLE   70,495 0 0
RADIUS HEALTH INC COM NEW 750469207 7,352 403,068 SH   SOLE   403,068 0 0
RADNET INC COM 750491102 1 20 SH   OTR 1 0 0 20
RADNET INC COM 750491102 10,417 309,191 SH   SOLE   309,191 0 0
RAYMOND JAMES FINL INC COM 754730109 3,504 26,978 SH   SOLE   26,978 0 0
REALTY INCOME CORP COM 756109104 1,613 24,164 SH   SOLE   24,164 0 0
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 568 82,523 SH   SOLE   82,523 0 0
REGENERON PHARMACEUTICALS COM 75886F107 9 17 SH   OTR 1 0 0 17
REGENERON PHARMACEUTICALS COM 75886F107 296,210 530,329 SH   SOLE   530,329 0 0
REGIONS FINANCIAL CORP NEW COM 7591EP100 25,920 1,284,435 SH   SOLE   1,284,435 0 0
RELAY THERAPEUTICS INC COM 75943R102 20,597 562,918 SH   SOLE   562,918 0 0
RELAY THERAPEUTICS INC COM 75943R102 1 20 SH   OTR 1 0 0 20
RENEWABLE ENERGY GROUP INC COM NEW 75972A301 1,448 23,235 SH   SOLE   23,235 0 0
REPLIGEN CORP COM 759916109 6,082 30,470 SH   SOLE   30,470 0 0
REPLIMUNE GROUP INC COM 76029N106 18,670 485,953 SH   SOLE   485,953 0 0
REPLIMUNE GROUP INC COM 76029N106 1 35 SH   OTR 1 0 0 35
REPUBLIC SVCS INC COM 760759100 5 42 SH   OTR 1 0 0 42
REPUBLIC SVCS INC COM 760759100 831 7,557 SH   SOLE   7,557 0 0
RESMED INC COM 761152107 4,661 18,907 SH   SOLE   18,907 0 0
RESTAURANT BRANDS INTL INC COM 76131D103 4,898 75,940 SH   SOLE   75,940 0 0
REVOLUTION MEDICINES INC COM 76155X100 12,507 394,056 SH   SOLE   394,056 0 0
REVOLUTION MEDICINES INC COM 76155X100 0 14 SH   OTR 1 0 0 14
RIGEL PHARMACEUTICALS INC COM NEW 766559603 9,642 2,221,696 SH   SOLE   2,221,696 0 0
RINGCENTRAL INC CL A 76680R206 1,330 4,577 SH   SOLE   4,577 0 0
RINGCENTRAL INC NOTE 3/0 76680RAF4 1,658 1,500 PRN   SOLE   1,500 0 0
RIO TINTO PLC SPONSORED ADR 767204100 2 21 SH   OTR 1 0 0 21
RIOT BLOCKCHAIN INC COM 767292105 220 5,840 SH   SOLE   5,840 0 0
ROBERT HALF INTL INC COM 770323103 4,994 56,127 SH   SOLE   56,127 0 0
ROCKWELL AUTOMATION INC COM 773903109 3 12 SH   OTR 1 0 0 12
ROCKWELL AUTOMATION INC COM 773903109 65,130 227,711 SH   SOLE   227,711 0 0
ROGERS COMMUNICATIONS INC CL B 775109200 2,465 46,324 SH   SOLE   46,324 0 0
ROKU INC COM CL A 77543R102 2,661 5,795 SH   SOLE   5,795 0 0
ROLLINS INC COM 775711104 1,362 39,835 SH   SOLE   39,835 0 0
ROPER TECHNOLOGIES INC COM 776696106 4,091 8,701 SH   SOLE   8,701 0 0
ROSS STORES INC COM 778296103 2,725 21,972 SH   SOLE   21,972 0 0
ROSS STORES INC COM 778296103 563 500 PRN   SOLE   500 0 0
ROYAL BK CDA COM 780087102 132,186 1,303,396 SH   SOLE   1,303,396 0 0
ROYAL BK CDA COM 780087102 5 47 SH   OTR 1 0 0 47
ROYAL DUTCH SHELL PLC SPONS ADR A 780259206 4 91 SH   OTR 1 0 0 91
S&P GLOBAL INC COM 78409V104 2 4 SH   OTR 1 0 0 4
S&P GLOBAL INC COM 78409V104 35,736 87,065 SH   SOLE   87,065 0 0
SAGE THERAPEUTICS INC COM 78667J108 7,872 138,568 SH   SOLE   138,568 0 0
SAILPOINT TECHNOLOGIES HLDGS COM 78781P105 37,702 738,233 SH   SOLE   738,233 0 0
SALESFORCE COM INC COM 79466L302 91,292 373,734 SH   SOLE   373,734 0 0
SALESFORCE COM INC COM 79466L302 2 9 SH   OTR 1 0 0 9
SAP SE SPON ADR 803054204 1 10 SH   OTR 1 0 0 10
SBA COMMUNICATIONS CORP NEW CL A 78410G104 2,428 7,619 SH   SOLE   7,619 0 0
SCHLUMBERGER LTD COM STK 806857108 16,382 511,775 SH   SOLE   511,775 0 0
SCHWAB CHARLES CORP COM 808513105 37,763 518,650 SH   SOLE   518,650 0 0
SCHWAB CHARLES CORP COM 808513105 2 33 SH   OTR 1 0 0 33
SEA LTD SPONSORD ADS 81141R100 378 1,375 SH   SOLE   1,375 0 0
SEAGEN INC COM 81181C104 5 29 SH   OTR 1 0 0 29
SEAGEN INC COM 81181C104 132,901 841,788 SH   SOLE   841,788 0 0
SEER INC COM CL A 81578P106 1,311 40,000 SH   SOLE   40,000 0 0
SELECT MED HLDGS CORP COM 81619Q105 2,756 65,206 SH   SOLE   65,206 0 0
SEMPRA ENERGY COM 816851109 5,048 38,101 SH   SOLE   38,101 0 0
SERVICENOW INC COM 81762P102 10,942 19,911 SH   SOLE   19,911 0 0
SHAW COMMUNICATIONS INC CL B CONV 82028K200 318 10,956 SH   SOLE   10,956 0 0
SHERWIN WILLIAMS CO COM 824348106 22,775 83,594 SH   SOLE   83,594 0 0
SHERWIN WILLIAMS CO COM 824348106 1 5 SH   OTR 1 0 0 5
SHINHAN FINANCIAL GROUP CO L SPN ADR RESTRD 824596100 430 12,000 SH   SOLE   12,000 0 0
SHOPIFY INC CL A 82509L107 2,932 2,003 SH   SOLE   2,003 0 0
SHOPIFY INC NOTE 0.125%11/0 82509LAA5 1,958 1,500 PRN   SOLE   1,500 0 0
SILICON LABORATORIES INC COM 826919102 35,457 231,369 SH   SOLE   231,369 0 0
SILICON LABORATORIES INC NOTE 0.625% 6/1 826919AD4 2,780 2,000 PRN   SOLE   2,000 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 0 13 SH   OTR 1 0 0 13
SILVERBACK THERAPEUTICS INC COM 82835W108 6,071 196,544 SH   SOLE   196,544 0 0
SIMON PPTY GROUP INC NEW COM 828806109 2,618 20,066 SH   SOLE   20,066 0 0
SIRIUS XM HOLDINGS INC COM 82968B103 216 32,995 SH   SOLE   32,995 0 0
SIRIUS XM HOLDINGS INC COM 82968B103 786 750 PRN   SOLE   750 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 1,684 8,781 SH   SOLE   8,781 0 0
SL GREEN RLTY CORP COM 78440X804 5,575 69,682 SH   SOLE   69,682 0 0
SLACK TECHNOLOGIES INC COM CL A 83088V102 26,194 591,282 SH   SOLE   591,282 0 0
SLEEP NUMBER CORP COM 83125X103 3,118 28,360 SH   SOLE   28,360 0 0
SMITH A O CORP COM 831865209 2,528 35,080 SH   SOLE   35,080 0 0
SMITH A O CORP COM 831865209 1 19 SH   OTR 1 0 0 19
SMUCKER J M CO COM NEW 832696405 12,683 97,889 SH   SOLE   97,889 0 0
SNAP INC CL A 83304A106 3,610 52,982 SH   SOLE   52,982 0 0
SNAP ON INC COM 833034101 1,396 6,249 SH   SOLE   6,249 0 0
SNOWFLAKE INC CL A 833445109 4,265 17,637 SH   SOLE   17,637 0 0
SOCIEDAD QUIMICA Y MINERA DE SPON ADR SER B 833635105 36,434 769,795 SH   SOLE   769,795 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 19,544 70,717 SH   SOLE   70,717 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 3 11 SH   OTR 1 0 0 11
SOLITON INC COM 834251100 1,524 67,770 SH   SOLE   67,770 0 0
SONY GROUP CORPORATION SPONSORED ADR 835699307 2,946 30,301 SH   SOLE   30,301 0 0
SONY GROUP CORPORATION SPONSORED ADR 835699307 4 39 SH   OTR 1 0 0 39
SOUTHERN COPPER CORP COM 84265V105 21,399 332,700 SH   SOLE   332,700 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 2,946 632,400 SH Put SOLE   632,400 0 0
SPLUNK INC COM 848637104 34,539 238,889 SH   SOLE   238,889 0 0
SPLUNK INC NOTE 1.125% 6/1 848637AF1 6,471 2,634,000 PRN   SOLE   2,634,000 0 0
SPORTSMANS WHSE HLDGS INC COM 84920Y106 12,600 709,064 SH   SOLE   709,064 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 1 9 SH   OTR 1 0 0 9
SPRINGWORKS THERAPEUTICS INC COM 85205L107 11,605 140,825 SH   SOLE   140,825 0 0
SPROUTS FMRS MKT INC COM 85208M102 801 32,221 SH   SOLE   32,221 0 0
SQUARE INC CL A 852234103 6,437 26,404 SH   SOLE   26,404 0 0
STANLEY BLACK & DECKER INC COM 854502101 1,468 7,159 SH   SOLE   7,159 0 0
STARBUCKS CORP COM 855244109 2 14 SH   OTR 1 0 0 14
STARBUCKS CORP COM 855244109 65,233 583,430 SH   SOLE   583,430 0 0
STATE STR CORP COM 857477103 3,714 45,139 SH   SOLE   45,139 0 0
STEEL DYNAMICS INC COM 858119100 1,196 20,074 SH   SOLE   20,074 0 0
STRYKER CORPORATION COM 863667101 42,568 163,895 SH   SOLE   163,895 0 0
STRYKER CORPORATION COM 863667101 2 8 SH   OTR 1 0 0 8
SUMITOMO MITSUI FINL GROUP I SPONSORED ADR 86562M209 1 137 SH   OTR 1 0 0 137
SUN CMNTYS INC COM 866674104 995 5,808 SH   SOLE   5,808 0 0
SUN LIFE FINANCIAL INC. COM 866796105 1,060 20,532 SH   SOLE   20,532 0 0
SUNCOR ENERGY INC NEW COM 867224107 775 32,317 SH   SOLE   32,317 0 0
SUNRUN INC COM 86771W105 665 11,917 SH   SOLE   11,917 0 0
SUTRO BIOPHARMA INC COM 869367102 6,807 366,183 SH   SOLE   366,183 0 0
SUTRO BIOPHARMA INC COM 869367102 0 24 SH   OTR 1 0 0 24
SVB FINANCIAL GROUP COM 78486Q101 1,618 2,907 SH   SOLE   2,907 0 0
SYNCHRONY FINANCIAL COM 87165B103 26,513 546,442 SH   SOLE   546,442 0 0
SYNOPSYS INC COM 871607107 30,604 110,970 SH   SOLE   110,970 0 0
SYNOPSYS INC COM 871607107 3 11 SH   OTR 1 0 0 11
SYROS PHARMACEUTICALS INC COM 87184Q107 3,184 584,272 SH   SOLE   584,272 0 0
SYSCO CORP COM 871829107 2,655 34,144 SH   SOLE   34,144 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 2 19 SH   OTR 1 0 0 19
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 94,802 788,968 SH   SOLE   788,968 0 0
TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS 874060205 1 78 SH   OTR 1 0 0 78
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 1,744 9,852 SH   SOLE   9,852 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 2,960 117,335 SH   SOLE   117,335 0 0
TALEND S A ADS 874224207 17,629 268,728 SH   SOLE   268,728 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 7,167 73,587 SH   SOLE   73,587 0 0
TARGET CORP COM 87612E106 3,525 3,250 PRN   SOLE   3,250 0 0
TARGET CORP COM 87612E106 2 9 SH   OTR 1 0 0 9
TARGET CORP COM 87612E106 29,064 120,228 SH   SOLE   120,228 0 0
TAYLOR MORRISON HOME CORP COM 87724P106 3,297 124,810 SH   SOLE   124,810 0 0
TC ENERGY CORP COM 87807B107 1,266 25,558 SH   SOLE   25,558 0 0
TCR2 THERAPEUTICS INC COM 87808K106 1 42 SH   OTR 1 0 0 42
TCR2 THERAPEUTICS INC COM 87808K106 15,335 934,509 SH   SOLE   934,509 0 0
TE CONNECTIVITY LTD REG SHS H84989104 2 18 SH   OTR 1 0 0 18
TECK RESOURCES LTD CL B 878742204 767 33,272 SH   SOLE   33,272 0 0
TELADOC HEALTH INC COM 87918A105 6,306 37,924 SH   SOLE   37,924 0 0
TELADOC HEALTH INC NOTE 1.250% 6/0 87918AAF2 1,138 1,000 PRN   SOLE   1,000 0 0
TELEDYNE TECHNOLOGIES INC COM 879360105 1,618 3,862 SH   SOLE   3,862 0 0
TELEFLEX INCORPORATED COM 879369106 1,043 2,596 SH   SOLE   2,596 0 0
TELEFONICA BRASIL SA NEW ADR 87936R205 111 13,078 SH   SOLE   13,078 0 0
TELEFONICA S A SPONSORED ADR 879382208 3 604 SH   OTR 1 0 0 604
TELUS CORPORATION COM 87971M103 488 21,734 SH   SOLE   21,734 0 0
TERADYNE INC COM 880770102 1,123 8,386 SH   SOLE   8,386 0 0
TERNIUM SA SPONSORED ADS 880890108 55,921 1,454,000 SH   SOLE   1,454,000 0 0
TERNIUM SA SPONSORED ADS 880890108 522 500 PRN   SOLE   500 0 0
TESLA INC COM 88160R101 1 2 SH   OTR 1 0 0 2
TESLA INC COM 88160R101 95,694 140,754 SH   SOLE   140,754 0 0
TETRA TECH INC NEW COM 88162G103 25,709 210,661 SH   SOLE   210,661 0 0
TETRA TECH INC NEW COM 88162G103 3 27 SH   OTR 1 0 0 27
TEXAS INSTRS INC COM 882508104 48,442 251,910 SH   SOLE   251,910 0 0
TEXAS INSTRS INC COM 882508104 2 9 SH   OTR 1 0 0 9
TG THERAPEUTICS INC COM 88322Q108 13,730 353,969 SH   SOLE   353,969 0 0
TG THERAPEUTICS INC COM 88322Q108 1 14 SH   OTR 1 0 0 14
THE TRADE DESK INC COM CL A 88339J105 221 2,860 SH   SOLE   2,860 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 6,907 475,696 SH   SOLE   475,696 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 9 17 SH   OTR 1 0 0 17
THERMO FISHER SCIENTIFIC INC COM 883556102 178,131 353,106 SH   SOLE   353,106 0 0
THOMSON REUTERS CORP. COM NEW 884903709 7,379 74,205 SH   SOLE   74,205 0 0
TILLYS INC CL A 886885102 1,918 120,000 SH   SOLE   120,000 0 0
TJX COS INC NEW COM 872540109 25,018 371,074 SH   SOLE   371,074 0 0
T-MOBILE US INC COM 872590104 4,801 33,151 SH   SOLE   33,151 0 0
TOPBUILD CORP COM 89055F103 5 27 SH   OTR 1 0 0 27
TOPBUILD CORP COM 89055F103 50,181 253,722 SH   SOLE   253,722 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 9,129 130,125 SH   SOLE   130,125 0 0
TOTALENERGIES SE SPONSORED ADS 89151E109 1 15 SH   OTR 1 0 0 15
TOYOTA MOTOR CORP SP ADR REP2COM 892331307 6 37 SH   OTR 1 0 0 37
TPI COMPOSITES INC COM 87266J104 1,636 33,783 SH   SOLE   33,783 0 0
TRACTOR SUPPLY CO COM 892356106 6,133 32,960 SH   SOLE   32,960 0 0
TRANE TECHNOLOGIES PLC SHS G8994E103 4 22 SH   OTR 1 0 0 22
TRANSUNION COM 89400J107 1,618 14,739 SH   SOLE   14,739 0 0
TRAVELERS COMPANIES INC COM 89417E109 18,305 122,272 SH   SOLE   122,272 0 0
TRAVELERS COMPANIES INC COM 89417E109 1 8 SH   OTR 1 0 0 8
TREACE MED CONCEPTS INC COM 89455T109 625 20,000 SH   SOLE   20,000 0 0
TREX CO INC COM 89531P105 2 20 SH   OTR 1 0 0 20
TREX CO INC COM 89531P105 17,364 169,887 SH   SOLE   169,887 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1 52 SH   OTR 1 0 0 52
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 7,663 790,046 SH   SOLE   790,046 0 0
TRIMBLE INC COM 896239100 7 81 SH   OTR 1 0 0 81
TRIMBLE INC COM 896239100 112,877 1,379,405 SH   SOLE   1,379,405 0 0
TRIP COM GROUP LTD ADS 89677Q107 2,231 62,910 SH   SOLE   62,910 0 0
TRUIST FINL CORP COM 89832Q109 5,176 93,260 SH   SOLE   93,260 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 2 21 SH   OTR 1 0 0 21
TURNING POINT THERAPEUTICS I COM 90041T108 40,618 520,604 SH   SOLE   520,604 0 0
TWILIO INC CL A 90138F102 5,764 14,623 SH   SOLE   14,623 0 0
TWIST BIOSCIENCE CORP COM 90184D100 9,706 72,841 SH   SOLE   72,841 0 0
TWITTER INC COM 90184L102 3,157 45,873 SH   SOLE   45,873 0 0
TWITTER INC NOTE 1.000% 9/1 90184LAD4 3,273 203,000 PRN   SOLE   203,000 0 0
TYLER TECHNOLOGIES INC COM 902252105 903 1,996 SH   SOLE   1,996 0 0
U S CONCRETE INC COM 90333L201 6,163 83,516 SH   SOLE   83,516 0 0
UBER TECHNOLOGIES INC COM 90353T100 1,438 28,687 SH   SOLE   28,687 0 0
UDR INC COM 902653104 318 6,499 SH   SOLE   6,499 0 0
UGI CORP NEW COM 902681105 1,741 37,599 SH   SOLE   37,599 0 0
ULTA BEAUTY INC COM 90384S303 1,649 4,769 SH   SOLE   4,769 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 4,718 49,480 SH   SOLE   49,480 0 0
UMPQUA HLDGS CORP COM 904214103 7,148 387,416 SH   SOLE   387,416 0 0
UNDER ARMOUR INC CL A 904311107 3,343 3,500 PRN   SOLE   3,500 0 0
UNDER ARMOUR INC CL A 904311107 401 18,978 SH   SOLE   18,978 0 0
UNILEVER PLC SPON ADR NEW 904767704 3,662 62,604 SH   SOLE   62,604 0 0
UNILEVER PLC SPON ADR NEW 904767704 5 80 SH   OTR 1 0 0 80
UNION PAC CORP COM 907818108 15,116 68,730 SH   SOLE   68,730 0 0
UNITED PARCEL SERVICE INC CL B 911312106 39,864 191,681 SH   SOLE   191,681 0 0
UNITED RENTALS INC COM 911363109 5,180 16,237 SH   SOLE   16,237 0 0
UNITEDHEALTH GROUP INC COM 91324P102 6 14 SH   OTR 1 0 0 14
UNITEDHEALTH GROUP INC COM 91324P102 137,463 343,279 SH   SOLE   343,279 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 2 9 SH   OTR 1 0 0 9
UNIVERSAL DISPLAY CORP COM 91347P105 41,451 186,439 SH   SOLE   186,439 0 0
US BANCORP DEL COM NEW 902973304 4,947 86,836 SH   SOLE   86,836 0 0
V F CORP COM 918204108 1 18 SH   OTR 1 0 0 18
V F CORP COM 918204108 27,463 334,753 SH   SOLE   334,753 0 0
VAIL RESORTS INC COM 91879Q109 15,622 49,357 SH   SOLE   49,357 0 0
VALE S A SPONSORED ADS 91912E105 291 12,775 SH   SOLE   12,775 0 0
VALERO ENERGY CORP COM 91913Y100 2,383 30,514 SH   SOLE   30,514 0 0
VALMONT INDS INC COM 920253101 3,110 13,174 SH   SOLE   13,174 0 0
VANECK VECTORS ETF TR RARE EARTH STRAT 92189H805 988 11,630 SH   SOLE   11,630 0 0
VANGUARD INDEX FDS LARGE CAP ETF 922908637 237 1,180 SH   SOLE   1,180 0 0
VARONIS SYS INC COM 922280102 37,824 656,431 SH   SOLE   656,431 0 0
VEEVA SYS INC CL A COM 922475108 6,539 21,028 SH   SOLE   21,028 0 0
VENTAS INC COM 92276F100 1,630 28,538 SH   SOLE   28,538 0 0
VEREIT INC COM 92339V308 929 20,218 SH   SOLE   20,218 0 0
VERISIGN INC COM 92343E102 1,605 7,051 SH   SOLE   7,051 0 0
VERISIGN INC COM 92343E102 2 9 SH   OTR 1 0 0 9
VERISK ANALYTICS INC COM 92345Y106 1,913 10,947 SH   SOLE   10,947 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 5 83 SH   OTR 1 0 0 83
VERIZON COMMUNICATIONS INC COM 92343V104 56,170 1,002,494 SH   SOLE   1,002,494 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 162,887 807,853 SH   SOLE   807,853 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 3 14 SH   OTR 1 0 0 14
VIACOMCBS INC CL B 92556H206 1,225 27,100 SH   SOLE   27,100 0 0
VIATRIS INC COM 92556V106 3,942 275,840 SH   SOLE   275,840 0 0
VIEWRAY INC COM 92672L107 8,183 1,239,817 SH   SOLE   1,239,817 0 0
VIEWRAY INC COM 92672L107 0 75 SH   OTR 1 0 0 75
VIPSHOP HOLDINGS LIMITED SPONSORED ADS A 92763W103 30,394 1,513,624 SH   SOLE   1,513,624 0 0
VISA INC COM CL A 92826C839 111,333 476,150 SH   SOLE   476,150 0 0
VISA INC COM CL A 92826C839 4 18 SH   OTR 1 0 0 18
VMWARE INC CL A COM 928563402 24,371 152,345 SH   SOLE   152,345 0 0
VMWARE INC CL A COM 928563402 2 12 SH   OTR 1 0 0 12
VODAFONE GROUP PLC NEW SPONSORED ADR 92857W308 1 55 SH   OTR 1 0 0 55
VONAGE HLDGS CORP COM 92886T201 1,253 75,700 SH   SOLE   75,700 0 0
VORNADO RLTY TR SH BEN INT 929042109 954 20,447 SH   SOLE   20,447 0 0
VOYA FINANCIAL INC COM 929089100 300 4,872 SH   SOLE   4,872 0 0
VULCAN MATLS CO COM 929160109 1,604 9,215 SH   SOLE   9,215 0 0
WABTEC COM 929740108 2,134 25,931 SH   SOLE   25,931 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 3,309 62,901 SH   SOLE   62,901 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 1 27 SH   OTR 1 0 0 27
WALMART INC COM 931142103 2,436 17,273 SH   SOLE   17,273 0 0
WASTE CONNECTIONS INC COM 94106B101 3 21 SH   OTR 1 0 0 21
WASTE CONNECTIONS INC COM 94106B101 29,827 249,747 SH   SOLE   249,747 0 0
WASTE MGMT INC DEL COM 94106L109 10 74 SH   OTR 1 0 0 74
WASTE MGMT INC DEL COM 94106L109 93,343 666,212 SH   SOLE   666,212 0 0
WATERS CORP COM 941848103 8,679 25,112 SH   SOLE   25,112 0 0
WAYFAIR INC CL A 94419L101 1,330 4,213 SH   SOLE   4,213 0 0
WEIBO CORP NOTE 1.250%11/1 948596AC5 3,903 4,000 PRN   SOLE   4,000 0 0
WELLS FARGO CO NEW COM 949746101 10,609 234,246 SH   SOLE   234,246 0 0
WELLTOWER INC COM 95040Q104 5,340 64,256 SH   SOLE   64,256 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 24,691 68,759 SH   SOLE   68,759 0 0
WESTERN DIGITAL CORP. COM 958102105 1,244 17,481 SH   SOLE   17,481 0 0
WESTERN DIGITAL CORP. NOTE 1.500% 2/0 958102AP0 12,907 12,000 PRN   SOLE   12,000 0 0
WESTERN UN CO COM 959802109 728 31,709 SH   SOLE   31,709 0 0
WESTPAC BANKING CORP SPONSORED ADR 961214301 2 97 SH   OTR 1 0 0 97
WESTROCK CO COM 96145D105 1,040 19,549 SH   SOLE   19,549 0 0
WEYERHAEUSER CO MTN BE COM NEW 962166104 16,271 472,721 SH   SOLE   472,721 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 749 16,990 SH   SOLE   16,990 0 0
WHIRLPOOL CORP COM 963320106 916 4,203 SH   SOLE   4,203 0 0
WILLIAMS COS INC COM 969457100 2,556 96,283 SH   SOLE   96,283 0 0
WORKDAY INC CL A 98138H101 3,146 13,177 SH   SOLE   13,177 0 0
WORKIVA INC COM CL A 98139A105 1,113 10,000 SH   SOLE   10,000 0 0
WP CAREY INC COM 92936U109 1,216 16,296 SH   SOLE   16,296 0 0
WYNN RESORTS LTD COM 983134107 933 7,629 SH   SOLE   7,629 0 0
XENCOR INC COM 98401F105 17,401 504,522 SH   SOLE   504,522 0 0
XENCOR INC COM 98401F105 1 22 SH   OTR 1 0 0 22
XENON PHARMACEUTICALS INC COM 98420N105 13,327 715,722 SH   SOLE   715,722 0 0
XILINX INC COM 983919101 17,989 124,372 SH   SOLE   124,372 0 0
XP INC CL A G98239109 2,178 50,000 SH   SOLE   50,000 0 0
XPENG INC ADS 98422D105 416 9,375 SH   SOLE   9,375 0 0
XPO LOGISTICS INC COM 983793100 845 6,044 SH   SOLE   6,044 0 0
XYLEM INC COM 98419M100 3 26 SH   OTR 1 0 0 26
XYLEM INC COM 98419M100 35,797 298,405 SH   SOLE   298,405 0 0
YAMANA GOLD INC COM 98462Y100 145 34,308 SH   SOLE   34,308 0 0
YETI HLDGS INC COM 98585X104 3,431 37,369 SH   SOLE   37,369 0 0
Y-MABS THERAPEUTICS INC COM 984241109 3,242 3,000 PRN   SOLE   3,000 0 0
Y-MABS THERAPEUTICS INC COM 984241109 6,022 178,169 SH   SOLE   178,169 0 0
Y-MABS THERAPEUTICS INC COM 984241109 0 12 SH   OTR 1 0 0 12
YUM BRANDS INC COM 988498101 2,156 18,741 SH   SOLE   18,741 0 0
YUM CHINA HLDGS INC COM 98850P109 4,346 65,600 SH   SOLE   65,600 0 0
ZAI LAB LTD ADR 98887Q104 11,618 65,643 SH   SOLE   65,643 0 0
ZAI LAB LTD ADR 98887Q104 1,606 1,500 PRN   SOLE   1,500 0 0
ZAI LAB LTD ADR 98887Q104 1 5 SH   OTR 1 0 0 5
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 6,911 13,053 SH   SOLE   13,053 0 0
ZENDESK INC COM 98936J101 775 5,369 SH   SOLE   5,369 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 1 14 SH   OTR 1 0 0 14
ZENTALIS PHARMACEUTICALS INC COM 98943L107 11,093 208,512 SH   SOLE   208,512 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 1,323 10,826 SH   SOLE   10,826 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 1 8 SH   OTR 1 0 0 8
ZIMMER BIOMET HOLDINGS INC COM 98956P102 25,790 160,363 SH   SOLE   160,363 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 779 500 PRN   SOLE   500 0 0
ZIONS BANCORPORATION N A COM 989701107 378 7,147 SH   SOLE   7,147 0 0
ZOETIS INC CL A 98978V103 10,029 53,816 SH   SOLE   53,816 0 0
ZOGENIX INC COM NEW 98978L204 9,275 536,758 SH   SOLE   536,758 0 0
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 4,153 10,731 SH   SOLE   10,731 0 0
ZSCALER INC COM 98980G102 13,593 62,914 SH   SOLE   62,914 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 1,518 50,000 SH   SOLE   50,000 0 0
ZYMEWORKS INC COM 98985W102 1 17 SH   OTR 1 0 0 17
ZYMEWORKS INC COM 98985W102 16,412 473,107 SH   SOLE   473,107 0 0
ZYNGA INC CL A 98986T108 273 25,700 SH   SOLE   25,700 0 0